DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and KRT13

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_705694.3	Gene:	KRT13 / 3860	HGNCID:	6415	Length:	458	Species:	Homo sapiens

Alignment Length:	250	Identity:	47/250 - (18%)
Similarity:	91/250 - (36%)	Gaps:	41/250 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 AGPATQFSSCQKNVLGEGNANRLCQKHSSPRLRQMHISNTRSCVLCGEDV-----SW-LPKVAAC 394
            ||....|.:|...:| .|| .::..::.:.||.. ::...|:......|:     .| |.:..|.
Human    86 AGGFVDFGACDGGLL-TGN-EKITMQNLNDRLAS-YLEKVRALEEANADLEVKIRDWHLKQSPAS 147

  Fly   395 PCCGYKPVPEFKERPYDEQATA----QQILL---------DHLENPVENLSFDMGSVEGCSANEE 446
            |...|.|..:..|...|:..||    .:::|         |......||......|||.    :.
Human   148 PERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEA----DI 208

  Fly   447 HGVPEPTSE----------AFEAIVKDYQLLRRSIRESNTKATQSATKNPTAQEGSAQPQDLAKV 501
            :|:.....|          ..|::.::...::::..|...:.:.........:..:....||.:|
Human   209 NGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRV 273

  Fly   502 FTELRDLFNVKAADENQKIQDICAEACALAKSHKKSKNRPASPERTKAGKTDPVE 556
            ..|:|:.:.. .|:.|::    .||.....||.:.:|....:....:..||:..|
Human   274 LAEMREQYEA-MAERNRR----DAEEWFHTKSAELNKEVSTNTAMIQTSKTEITE 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	37/214 (17%)
KRT13	NP_705694.3	Head	1..103		5/17 (29%)
		Filament	103..415	CDD:306535	40/231 (17%)
		Coil 1A	104..139		4/35 (11%)
		Linker 1	140..158		5/17 (29%)
		Coil 1B	159..250		15/94 (16%)
		Linker 12	251..273		2/21 (10%)
		Coil 2	274..412		11/54 (20%)
		Tail	413..458
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900