DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppi1 and KRT12

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_000214.1	Gene:	KRT12 / 3859	HGNCID:	6414	Length:	494	Species:	Homo sapiens

Alignment Length:	342	Identity:	65/342 - (19%)
Similarity:	107/342 - (31%)	Gaps:	130/342 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 DGRLAGGQERGCFPNMNVDLQDLSFMSTSSIDPCVGFMPSDTEVAQDSPPCSEDRAQDSFQCQDS 306
            ||.|..|.|:....|:|..|       .|.:|.......::||:........|.|...:.....|
Human   117 DGGLLSGSEKETMQNLNDRL-------ASYLDKVRALEEANTELENKIREWYETRGTGTADASQS 174

  Fly   307 PPRLIDMAGPYPVYSCPNVDDDCVTFEPPAGPATQFSSCQKNVLGE--GNANRLCQKHSSPRLRQ 369
                 |.:..||:     ::|                 .:..::..  |||..|.|
Human   175 -----DYSKYYPL-----IED-----------------LRNKIISASIGNAQLLLQ--------- 203

  Fly   370 MHISNTRSCVLCGEDVSWLPKVAACPCCGYKPVPEFKERPYDEQATAQQI---------LLDH-- 423
              |.|.|   |..||                    |:.:..:|.|..|.:         :||.
Human   204 --IDNAR---LAAED--------------------FRMKYENELALRQGVEADINGLRRVLDELT 243

  Fly   424 -----LENPVENLSFDMGSVEGCSANEEH-------GVPEPTSEAFEA--------IVKDYQLLR 468
                 ||..:|:|:.::..::   .|.|.       |.|...|...:|        ::.|.:...
Human   244 LTRTDLEMQIESLNEELAYMK---KNHEDELQSFRVGGPGEVSVEMDAAPGVDLTRLLNDMRAQY 305

  Fly   469 RSIRESNTKATQS-------------ATKNPTAQEGSAQPQDLAKVF----TELRDLFNVKAADE 516
            .:|.|.|.|..::             :|.....|...::..||.:.|    .||:....:|
Human   306 ETIAEQNRKDAEAWFIEKSGELRKEISTNTEQLQSSKSEVTDLRRAFQNLEIELQSQLAMK---- 366

  Fly   517 NQKIQDICAEA----CA 529
             :.::|..|||    ||
Human   367 -KSLEDSLAEAEGDYCA 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	12/51 (24%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	41/211 (19%)
KRT12	NP_000214.1	Head	1..124		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Filament	124..436	CDD:278467	61/335 (18%)
		Coil 1A	125..160		8/41 (20%)
		Linker 1	164..182		4/22 (18%)
		Coil 1B	183..274		24/144 (17%)
		Linker 12	275..297		4/21 (19%)
		Coil 2	298..435		19/90 (21%)
		Tail	436..494
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..468
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900