DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and KRT9

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_000217.2	Gene:	KRT9 / 3857	HGNCID:	6447	Length:	623	Species:	Homo sapiens

Alignment Length:	350	Identity:	58/350 - (16%)
Similarity:	107/350 - (30%)	Gaps:	141/350 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 AGGQERGCF-PNMNVDLQDLSFMSTSSIDPCVGFMPSDTEVAQDSPPCSEDRAQDSFQCQDSPPR 309
            |||.:.|.. .|....:|:|:....|.:|.......::.::        |::.||.:
Human   141 AGGGDGGILTANEKSTMQELNSRLASYLDKVQALEEANNDL--------ENKIQDWY-------- 189

  Fly   310 LIDMAGP-------YPVYSCPNVDD--DCVTFEPPAGPATQFSSCQKNVLGEGNANRLCQKHSSP 365
              |..||       .|.|:  .:||  |.:.                 .|..||...|
Human   190 --DKKGPAAIQKNYSPYYN--TIDDLKDQIV-----------------DLTVGNNKTL------- 226

  Fly   366 RLRQMHISNTRSCVLCGEDVSWLPKVAACPCCGYKPVPEFKERPYDEQATAQQILLD--HLENPV 428
                :.|.|||                       ..:.:|:.:...||...|.:..|  .|...:
Human   227 ----LDIDNTR-----------------------MTLDDFRIKFEMEQNLRQGVDADINGLRQVL 264

  Fly   429 ENLSFDMGSVEGCSANEEHGVPEPTSEAFEAIVKDYQLLRRSIRESNTKATQSATKNPTAQEGSA 493
            :||:.:...:|               ..:|.:.::...|:::.:|..::.|...:.:...:...|
Human   265 DNLTMEKSDLE---------------MQYETLQEELMALKKNHKEEMSQLTGQNSGDVNVEINVA 314

  Fly   494 QPQDLAKVFTELRDLFNVKAAD-----ENQ----------------------------------- 518
            ..:||.|...::|..:....|.     |||
Human   315 PGKDLTKTLNDMRQEYEQLIAKNRKDIENQYETQITQIEHEVSSSGQEVQSSAKEVTQLRHGVQE 379

  Fly   519 ---KIQDICAEACALAKSHKKSKNR 540
               ::|...::..||.||.:.:|||
Human   380 LEIELQSQLSKKAALEKSLEDTKNR 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	9/48 (19%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	33/214 (15%)
KRT9	NP_000217.2	Head	1..152		4/10 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Filament	152..464	CDD:365827	53/338 (16%)
		Coil 1A	153..188		6/42 (14%)
		Linker 1	189..207		5/29 (17%)
		Coil 1B	208..299		23/156 (15%)
		Linker 12	300..322		4/21 (19%)
		Coil 2	323..461		12/81 (15%)
		Tail	462..623
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..496
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..623
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900