DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and Krt19

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_955792.1	Gene:	Krt19 / 360626	RGDID:	619936	Length:	403	Species:	Rattus norvegicus

Alignment Length:	334	Identity:	61/334 - (18%)
Similarity:	106/334 - (31%)	Gaps:	127/334 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 DGRLAGGQERGCFPNMNVDLQDLSFMSTSSIDPCVGFMPSDTEVAQDSPPCSEDRAQDSFQCQDS 306
            || |.||.|:       :.:|:|:....|.:|.......::.|:        |.:.:|.:|.|.
  Rat    76 DG-LLGGNEK-------ITMQNLNDRLASYLDKVRALEQANGEL--------EVKIRDWYQKQG- 123

  Fly   307 PPRLIDMAGPYPVYS--CPNVDDDCVTFEPPAGPATQFSSCQKNVLGEGNANRLCQKHSSPRLRQ 369
                   .||:..||  ...::|                 .:..:||....|...         .
  Rat   124 -------PGPFRDYSQYFKTIED-----------------LRDKILGATIENSKI---------V 155

  Fly   370 MHISNTRSCVLCGEDVSWLPKVAACPCCGYKPVPEFKERPYDEQATAQQI---------LLDH-- 423
            :.|.|.|   |..:|                    |:.:...|||....:         :||.
  Rat   156 LQIDNAR---LAADD--------------------FRTKFETEQALRMSVEADINGLRRVLDELT 197

  Fly   424 -----LENPVENLSFDMGSVEGCSANEEHGVPEPTSEAFEAIVKDYQLLRRSIRESNTKATQSAT 483
                 ||..:|||..::..::     :.|                         |....|.:|..
  Rat   198 LARTDLEMQIENLKEELAYLK-----KNH-------------------------EEEISALRSQV 232

  Fly   484 KNPTAQEGSAQPQ-DLAKVFTELRDLFNVKAADENQKIQDICAEACALAKSHKKSKNRPASPERT 547
            ....:.|..:.|. ||||:.:|:|..:.. .|::|:|    .|||..|.:..:.:........:.
  Rat   233 GGQVSVEVDSTPGIDLAKILSEMRSQYEA-MAEKNRK----DAEAWYLTQIDELNTQVAVHTTQI 292

  Fly   548 KAGKTDPVE 556
            :..||:..|
  Rat   293 QINKTEVTE 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	11/51 (22%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	38/203 (19%)
Krt19	NP_955792.1	Head	1..82		4/6 (67%)
		Filament	82..393	CDD:278467	56/327 (17%)
		Coil 1A	83..118		7/49 (14%)
		Linker 1	119..136		6/24 (25%)
		Coil 1B	137..228		22/169 (13%)
		Linker 12	229..251		6/21 (29%)
		Necessary for interaction with PNN. /evidence=ECO:0000250	247..393		16/60 (27%)
		Coil 2	252..390		12/55 (22%)
		Rod-like helical tail	391..403
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900