DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and Krt36

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_001167570.1	Gene:	Krt36 / 16673	MGIID:	109364	Length:	473	Species:	Mus musculus

Alignment Length:	403	Identity:	71/403 - (17%)
Similarity:	124/403 - (30%)	Gaps:	152/403 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LVSTRLGSCKADYMHCSTYQEKGNAQEKDKKGKGACCCSSCPVRNREEVYQPR-CPAPGQKGKPN 96
            :::.||    |:|:......|:.|.|            ..|.:|...|...|. ||
Mouse    99 ILNDRL----ANYLEKVRQLEQENTQ------------LECRIREWYECQIPYICP--------- 138

  Fly    97 RDYMRCFA----------------AKLIVQ--KLNMPGRDFECQDKLQ------IKANVCRGCK- 136
             ||...|.                |:||:|  ...:...||..:.:.:      ::|:: .|.:
Mouse   139 -DYQSYFKTAEELQQKILLTKSENARLILQIDNAKLAADDFRTKYETELSLRQLVEADI-NGLRR 201

  Fly   137 ------ICLGSSSINVN-------CLPLNPDKTFQMEAECLQRQLAEGINISV-----VYLRKEI 183
                  :|.......|.       ||..|.::    |...|:.||.:.:|:.|     |.|.|.:
Mouse   202 ILDELTLCKADLEAQVESLKEELLCLKRNHEE----EVNALRSQLGDRLNVEVDAAPPVDLNKIL 262

  Fly   184 -ARGCYFPPAAVVSR---------MINDFDEIVHDANVELTCKGCTVGIMNIR-----FAMQMRC 233
             ...|.:......:|         ...:.::.|..::.:|.|  |...|:.:|     ..::::.
Mouse   263 DDMRCQYETLVENNRRDVEAWFNTQTEELNQQVVSSSEQLQC--CQTEIIELRRTVNSLEIELQA 325

  Fly   234 QTLKEDAVDGRLAG---------GQERGCFPNMNVDLQDLSFMSTSSIDPCVGFMPSDTEVAQDS 289
            |....::::..||.         ||.:....|:...|.::.
Mouse   326 QQSMRNSLESTLAETEARYSSQLGQMQCLITNVESQLAEIR------------------------ 366

  Fly   290 PPCSEDRAQDSFQ-CQDSPPRLIDMAGPY-----------PVYSCPNVDDDC-----VTFEP--- 334
              |..:|....:| ..|...||......|           |.:.|   ..:|     |.:.|
Mouse   367 --CDLERQNHEYQVLLDVKARLESEIATYRRLLDGEDCKLPAHPC---STECKPAVRVPYIPSTT 426

  Fly   335 --PAGPATQFSSC 345
              ||||.|....|
Mouse   427 CTPAGPCTPAGPC 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	36/236 (15%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622
Krt36	NP_001167570.1	Head. /evidence=ECO:0000255	1..93
		Filament	92..403	CDD:365827	60/362 (17%)
		Coil 1A. /evidence=ECO:0000255	94..128		9/44 (20%)
		Linker 1. /evidence=ECO:0000255	129..139		4/19 (21%)
		Coil 1B. /evidence=ECO:0000255	140..240		17/104 (16%)
		Linker 12. /evidence=ECO:0000255	241..256		4/14 (29%)
		Coil 2. /evidence=ECO:0000255	257..400		24/170 (14%)
		Tail. /evidence=ECO:0000255	401..473		11/42 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900