DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and Krt17

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_034793.1	Gene:	Krt17 / 16667	MGIID:	96691	Length:	433	Species:	Mus musculus

Alignment Length:	325	Identity:	64/325 - (19%)
Similarity:	114/325 - (35%)	Gaps:	113/325 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 VDGRLAGGQERGCFPNMNVDLQDLSFMSTSSIDPCVGFMPSDTEVAQDSPPCSEDRAQDSFQCQD 305
            |||.||||::        ..:|:|:....|.:|.......::||:        |.:.:|.:|.|
Mouse    76 VDGLLAGGEK--------ATMQNLNDRLASYLDKVRALEEANTEL--------EVKIRDWYQKQ- 123

  Fly   306 SPPRLIDMAGPYPVYSCPNVDDDCVTFEPPAGPATQFSSCQ------KN---VLGEGNANRLCQK 361
            :|                             |||..:|:..      ||   |....||:.|.|
Mouse   124 AP-----------------------------GPARDYSAYYHTIEDLKNKILVATVDNASILLQ- 158

  Fly   362 HSSPRLRQMHISNTRSCVLCGEDVSWLPKVAACPCCGYKPVPEFKERPYDEQATAQQILLD--HL 424
                      |.|.|   |..:|                    |:.:...|||....:..|  .|
Mouse   159 ----------IDNAR---LAADD--------------------FRTKFETEQALRMSVEADINGL 190

  Fly   425 ENPVENLSFDMGSVEGCSANEEHGVPEPTSEAFEAIVKDYQLLRRSIRESNTKATQSATKNPTAQ 489
            ...::.|:.....:|               ...|.:.::...|::: .|....|.:.........
Mouse   191 RRVLDELTLARADLE---------------MQIENLKEELAYLKKN-HEEEMNALRGQVGGEINV 239

  Fly   490 EGSAQP-QDLAKVFTELRDLFNVKAADENQKIQDICAEACALAKSHKKSKNRPASPERTKAGKTD 553
            |..|.| .||:::.:|:||.:. |.|::|:|    .||....:|:.:.::....:.|..::||::
Mouse   240 EMDAAPGVDLSRILSEMRDQYE-KMAEKNRK----DAEDWFFSKTEELNREVATNSELVQSGKSE 299

Fly 554 553
Mouse 300 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	13/52 (25%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	35/186 (19%)
Krt17	NP_034793.1	Head	1..83		5/6 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Filament	84..394	CDD:333788	57/317 (18%)
		Coil 1A	84..120		8/51 (16%)
		Linker 1	121..138		7/46 (15%)
		Coil 1B	139..230		24/140 (17%)
		Linker 12	231..250		4/18 (22%)
		Coil 2	251..392		13/54 (24%)
		Tail	393..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900