DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and KRT28

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_853513.2	Gene:	KRT28 / 162605	HGNCID:	30842	Length:	464	Species:	Homo sapiens

Alignment Length:	262	Identity:	48/262 - (18%)
Similarity:	88/262 - (33%)	Gaps:	74/262 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 CVGFMPSDTEVAQDSPPCSEDRAQDSFQCQDSPPRLIDMA---------GPYPVY---SCPNVDD 327
            |:||..|:..:...:...:.....|.........|.::.|         |.|..|   ||..:|.
Human    71 CIGFAGSEGGLLSGNEKVTMQNLNDRLASYLDNVRALEEANAELERKIKGWYEKYGPGSCRGLDH 135

  Fly   328 DC----VTFEPPAGPATQFSSCQKNVLGEGNANRLCQKHSSPRLRQMHISNTRSCVLCGEDVSWL 388
            |.    :|.|.........::...||:                   :.|.|.|   |..:|
Human   136 DYSRYHLTIEDLKNKIISSTTTNANVI-------------------LQIDNAR---LAADD---- 174

  Fly   389 PKVAACPCCGYKPVPEFKERPYDEQATAQQILLDHLENPVENLSFDMGSVEGCSANEEHGVPEPT 453
                            |:.: |:.:.|..|    ::|..:..|...:..:..|..::|
Human   175 ----------------FRLK-YENELTLHQ----NVEADINGLRRVLDELTLCRTDQE------- 211

  Fly   454 SEAFEAIVKDYQLLRRSIRESNTKATQSATKNPTAQEGSAQP-QDLAKVFTELRDLFNVKAADEN 517
             ..:|::.::...|::: .|...||.|.|.......|.:|.| .|||.:...:|..:.. .|::|
Human   212 -LQYESLSEEMTYLKKN-HEEEMKALQCAAGGNVNVEMNAAPGVDLAVLLNNMRAEYEA-LAEQN 273

  Fly   518 QK 519
            :|
Human   274 RK 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	4/18 (22%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	30/150 (20%)
KRT28	NP_853513.2	Head. /evidence=ECO:0000255	1..85		4/13 (31%)
		Filament	85..396	CDD:278467	44/248 (18%)
		Coil 1A. /evidence=ECO:0000255	86..121		3/34 (9%)
		Linker 1. /evidence=ECO:0000255	122..143		6/20 (30%)
		Coil 1B. /evidence=ECO:0000255	144..235		20/146 (14%)
		Linker 12. /evidence=ECO:0000255	236..258		8/21 (38%)
		Coil 2. /evidence=ECO:0000255	259..397		4/18 (22%)
		Tail. /evidence=ECO:0000255	398..464
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900