Protein Alignment sima and ARNT2

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_055677.3
• Gene: ARNT2 / 9915
• HGNCID: 16876
• Length: 717
• Species: Homo sapiens
• Alignment Length: 791
• Identity: 170/791 - (21%)
• Similarity: 280/791 - (35%)
• Gaps: 236/791 - (29%)

  Fly   149 DIEDFMNNEK-RKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIRE 212
            |.||.....| .:|...:..|.||:|.|:...|||..:|..:....:.||.:::|:.::.:|
Human    53 DDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK--- 114

  Fly   213 MLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHE-G 276
                  |:|...:        .......||       .:|...|.:.|:.:..||||.|::.| |
Human   115 ------SMRGTGN--------KSTDGAYKP-------SFLTEQELKHLILEAADGFLFVVAAETG 158

  Fly   277 DITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLK------RELAQK---VKDEPQ 332
            .:.|||::|...|...:.:..|..::|..|..|..:::|.|...      |.|..|   ||.|.|
Human   159 RVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQ 223

  Fly   333 QNS-----GVSTHHRDLFVRLKC--------------TLTSRGRS----INIKSASYKVIHITGH 374
            |:|     |   ..|....|::|              |:..|.|:    :....|.|.|:|.||:
Human   224 QSSMRMCMG---SRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGY 285

  Fly   375 LV---------------VNAKGERLLMAIGR------PIPHPSN-IEIPLGTSTFLTKHSLDMRF 417
            :.               |....:..|:||||      |:....| :.:|   :.||::|:.|...
Human   286 IKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVP---TEFLSRHNSDGII 347

  Fly   418 TYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLS-KGQGETSRYRFLGKYGGYCW 481
            |:||.:...::||.|:|||...:....|..|...|..:|:.|:. |||..:..|||..|  ...|
Human   348 TFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTK--NREW 410

  Fly   482 ILSQATIVYDKLKPQS-----VVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPE 541
            :|.: |..:....|.|     ::|.|                     :..|:...|.||.|....
Human   411 MLIR-TSSFTFQNPYSDEIEYIICTN---------------------TNVKQLQQQQAELEVHQR 453

  Fly   542 KAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQL 606
            .......::|.....:...:|              :|.|::|
Human   454 DGLSSYDLSQVPVPNLPAGVH--------------EAGKSVE----------------------- 481

  Fly   607 PESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTP 671
                      :|:.:..:|.   .||  .|::.:|.|:.   |:|...|.:|:..:
Human   482 ----------KADAIFSQER---DPR--FAEMFAGISAS---EKKMMSSASAAGTQ--------- 519

  Fly   672 PPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADD 736
               .:..:.:|.       |:..:..|..||   .:.:.....:|:.....|:||:
Human   520 ---QIYSQGSPF-------PSGHSGKAFSSS---VVHVPGVNDIQSSSSTGQNMSQ--------- 562

  Fly   737 GRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQH 801
                         :|..|..:.........||....:        |...:...|:......|..:
Human   563 -------------ISRQLNQSQVAWTGSRPPFPGQQI--------PSQSSKTQSSPFGIGTSHTY 606

  Fly   802 YQSPSS-SSTSAPSNTSSSNNSYANSPLSPLTP-------NSTATASNPSH---QQQQQHHNQQQ 855
            ...||| |..|:|:.:|.|.|:|  |.|:..||       :|......||.   |.|.|||.||.
Human   607 PADPSSYSPLSSPATSSPSGNAY--SSLANRTPGFAESGQSSGQFQGRPSEVWSQWQSQHHGQQS 669

  Fly   856 QQQQQQQHHPQ 866
            .:|...|...|
Human   670 GEQHSHQQPGQ 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	14/56 (25%)
		PAS	256..392	CDD:395786	48/189 (25%)
		PAS	265..>317	CDD:238075	17/52 (33%)
		PAS	404..505	CDD:238075	32/106 (30%)
ARNT2	NP_055677.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..74		5/20 (25%)
		bHLH-PAS_ARNT	62..124	CDD:381517	17/78 (22%)
		PAS	137..243	CDD:395786	32/108 (30%)
		PAS_11	336..436	CDD:464214	32/123 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	548..717		38/165 (23%)