DRSC/TRiP Functional Genomics Resources

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Protein Alignment sima and CLOCK

DIOPT Version :10

Sequence 1:NP_001287599.1 Gene:sima / 43580 FlyBaseID:FBgn0266411 Length:1593 Species:Drosophila melanogaster
Sequence 2:NP_004889.1 Gene:CLOCK / 9575 HGNCID:2082 Length:846 Species:Homo sapiens


Alignment Length:984 Identity:220/984 - (22%)
Similarity:367/984 - (37%) Gaps:251/984 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 TQPC-QFSQFVDIEDFM---------NNEKRKEKSRD-AARCRRSKETEIFMELSAALPLKTDDV 192
            |..| :.|..||.:|..         :.:|.|..||: :.:.||.:...:..||.:.||   .:.
Human     4 TVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNA 65

  Fly   193 NQLDKASVMRITIAFLKIREMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDW----LN 253
            .::||::|::.:|.||:..                 ::|....|..|::       :||    |:
Human    66 RKMDKSTVLQKSIDFLRKH-----------------KEITAQSDASEIR-------QDWKPTFLS 106

  Fly   254 GAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALS 318
            ..|..:|:.:.:|||.|.:..:|.|.||||:|...|.....|.:.|.|:.:..:.:|:|:.:.||
Human   107 NEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILS 171

  Fly   319 LKRELAQKVKDEPQQNSGVSTHHRDLFVRLK-----CTLTSRGRSINIKSASYKVIHITGHL--- 375
              ..|.:.....|:            :::.|     |....||.....:.::|:.:...|:.   
Human   172 --THLLESDSLTPE------------YLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSL 222

  Fly   376 -VVNAKG----ERLLMAIGRP-------------------IPHPSNIEIPLGTSTFLTKHSLDMR 416
             .|::..    |..:....||                   |.....:|.|  ...|.::|||:.:
Human   223 NSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVEEP--NEEFTSRHSLEWK 285

  Fly   417 FTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCW 481
            |.::|.:...::||.|.::|.||.:...|..|.|.|....:.::..|:|::..||||.|...:.|
Human   286 FLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIW 350

  Fly   482 ILSQATIVYDK--LKPQSVVCVNYVISNLENKHE------IYSLAQQTAASEQKEQHHQAAETEK 538
            :.:...|.|.:  .:|:.:||.:.|:|..|.:.|      |.....:|||             :|
Human   351 LQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAA-------------DK 402

  Fly   539 EPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTI--EETKTIATIPPVTATSTAD 601
            ..:..:|..|.....||.:....|:....|.  ...|.|:..|.  :.:.|...||  |.|||  
Human   403 SQDSGSDNRINTVSLKEALERFDHSPTPSAS--SRSSRKSSHTAVSDPSSTPTKIP--TDTST-- 461

  Fly   602 QIKQLPESNPYKQILQA-ELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSP 665
                     |.:|.|.| |.:::|.:      :.::|.::..|.|        .|:|..|:..:.
Human   462 ---------PPRQHLPAHEKMVQRRS------SFSSQSINSQSVG--------SSLTQPVMSQAT 503

  Fly   666 APPLTPPPTAVLCKKTPLG----VEPNLPPTTTATAAIISSSNQQL-QIAQQTQL---QNPQQPA 722
            ..|: |...:.......||    ::..|...|....|.|....::| :|.:|.|:   |..|...
Human   504 NLPI-PQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVHGQGLQMFL 567

  Fly   723 QDMSKG--FCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDI 785
            |..:.|  |.|:....|....:.:..|.::...:..||.||       |.|..|.:||.......
Human   568 QQSNPGLNFGSVQLSSGNSSNIQQLAPINMQGQVVPTNQIQ-------SGMNTGHIGTTQHMIQQ 625

  Fly   786 NSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQQQQH 850
            .:|.||   :|.|.|:..|..|..||.||.|                 .||.||           
Human   626 QTLQST---STQSQQNVLSGHSQQTSLPSQT-----------------QSTLTA----------- 659

  Fly   851 HNQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDSSLPSLC 915
                                        ||:|....|...:.|.    ..|.|..|::|:  ...
Human   660 ----------------------------PLYNTMVISQPAAGSM----VQIPSSMPQNST--QSA 690

  Fly   916 SPNSLTQEDDFSF---EAFAMRAPYIPIDDDMPLLTETDLMWCPPEDLQTMVPKEIDAIQQQ--- 974
            :..:.||:....|   :....:....|:.....::..|.||.      |.:......|.|||   
Human   691 AVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMG------QVVTAYPTFATQQQQSQ 749

  Fly   975 ---LQQLQQQHHQQYAGNTGYQQQQQ----QPQLQQQHFSNSLCSSPASTVSSLSPSPVQQ---- 1028
               :.|.|||...|....|..||..|    ||..|....|..|..:|::.:...:..|:||    
Human   750 TLSVTQQQQQQSSQEQQLTSVQQPSQAQLTQPPQQFLQTSRLLHGNPSTQLILSAAFPLQQSTFP 814

  Fly  1029 --HHQQQQA 1035
              ||||.|:
Human   815 QSHHQQHQS 823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simaNP_001287599.1 bHLH-PAS_HIF 159..216 CDD:381439 15/57 (26%)
PAS 256..392 CDD:395786 33/167 (20%)
PAS 265..>317 CDD:238075 17/51 (33%)
PAS 404..505 CDD:238075 29/102 (28%)
CLOCKNP_004889.1 bHLH-PAS_CLOCK 29..89 CDD:381577 17/79 (22%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O08785 32..47 4/14 (29%)
PAS 109..>175 CDD:395786 21/67 (31%)
PAS_11 274..377 CDD:464214 30/102 (29%)
Interaction with NR3C1. /evidence=ECO:0000250|UniProtKB:O08785 371..845 128/574 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..411 5/31 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..495 22/103 (21%)
Interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:O08785 450..570 34/147 (23%)
Implicated in the circadian rhythmicity. /evidence=ECO:0000250 514..564 11/49 (22%)
SP1-4_N 550..>694 CDD:425404 46/215 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 624..654 13/49 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..783 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 811..846 5/13 (38%)

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