DRSC/TRiP Functional Genomics Resources

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Protein Alignment sima and hif1aa

DIOPT Version :10

Sequence 1:NP_001287599.1 Gene:sima / 43580 FlyBaseID:FBgn0266411 Length:1593 Species:Drosophila melanogaster
Sequence 2:NP_001295488.1 Gene:hif1aa / 797150 ZFINID:ZDB-GENE-080917-55 Length:717 Species:Danio rerio


Alignment Length:746 Identity:236/746 - (31%)
Similarity:354/746 - (47%) Gaps:207/746 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 MNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVP 218
            :::|:|||||||||||||.||:|:|.|||..|||.....:.||||||||:.:::|::|::|    
Zfish    11 VSSERRKEKSRDAARCRRGKESEVFYELSRELPLPHSVTSNLDKASVMRLALSYLRLRKLL---- 71

  Fly   219 SLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSE 283
                 |.|:.:. |||.|.|            | ||:    .|| .:||||||||.:|||.|:||
Zfish    72 -----NSDVLEK-ETALDTQ------------W-NGS----FLK-ALDGFLLVLSADGDIVYLSE 112

  Fly   284 NVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRL 348
            ||.:.||:.:|:..|..::|::|.|||.|::|.|:.:..|::|.||   ||:     :|...:|:
Zfish   113 NVSKCLGLPQIELTGHSVFEFTHPCDHEELREMLAHRFGLSKKSKD---QNT-----NRSFLLRM 169

  Fly   349 KCTLTSRGRSINIKSASYKVIHITGHL---------VVNAKG--ERLLMAIGRPIPHPSNIEIPL 402
            |||||||||::|:||||:||:..:|.:         |...|.  ...|:.|...||||:|||.||
Zfish   170 KCTLTSRGRTVNVKSASWKVLRCSGRIHTADGVEKEVCEEKNTCSTYLVLICESIPHPANIEAPL 234

  Fly   403 GTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGET 467
            .:.|||::|:|||||||.|:::.:|||:.|:|:|..|::...|..||:.:..|..|:..|||..|
Zfish   235 DSRTFLSRHTLDMRFTYCDERITELLGFDPEDVLQHSVYEYYHALDSDHMTKTHHSLFVKGQVCT 299

  Fly   468 SRYRFLGKYGGYCWILSQATIVYDKLKPQS--VVCVNYVISNLENKHEIYSLAQQTAASEQKEQH 530
            .:||.|.|.||:.|..:|||::|:....|:  ||||||::|.:|...:|.||.|..:...::|:|
Zfish   300 GQYRLLAKAGGFVWAETQATVIYNSKNSQAQCVVCVNYILSGIEQPKQILSLQQTNSTKIKQEEH 364

  Fly   531 HQAAETE----KEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATI 591
            .:..|..    ||.||..|     :|.:|.|...:..:.|:.               ||:.:...
Zfish   365 QEEVEVTMAELKEEEKEMD-----KEDEECVQPVVQHNSLKG---------------ETEALTVA 409

  Fly   592 PPVTATS---TADQIKQLPESNPYKQIL--QAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEK 651
            .||....   |...|..|.|...|..::  .:::|:                             
Zfish   410 DPVLTLDINITDSAISVLTEIPLYNDVMLPSSDVLL----------------------------- 445

  Fly   652 RPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQ 716
                         |..||:||     |                      ||.|.  ..|....||
Zfish   446 -------------PLSPLSPP-----C----------------------SSLND--DEASTGHLQ 468

  Fly   717 NPQQPAQDMSKGFCSLFADDGRGLTML--------KEEPDDLSHHL-----ASTNCIQLD-EM-T 766
            :.|.|.|..|        |..|....|        :.:||.:..|.     :.|..:.|| || .
Zfish   469 HDQFPFQQSS--------DSSRSQVDLPVDSELCDQLKPDHVEKHFSMDIESKTQGVGLDLEMLA 525

  Fly   767 PFSDMLVGLMGTCLLPEDINSLDSTT-----CSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANS 826
            |:..|           :|...|.:.:     ||:..||... :||||:.::|:            
Zfish   526 PYIPM-----------DDDFQLRTVSPVRPMCSSPCSGLDL-TPSSSTQTSPA------------ 566

  Fly   827 PLSPLTPNSTATASNPSHQQQQ---QHHNQQ 854
             ||..||:|  .:.:|..|:.:   |.|:::
Zfish   567 -LSAATPDS--LSCDPVQQKNKTTVQDHSRE 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simaNP_001287599.1 bHLH-PAS_HIF 159..216 CDD:381439 34/56 (61%)
PAS 256..392 CDD:395786 59/146 (40%)
PAS 265..>317 CDD:238075 27/51 (53%)
PAS 404..505 CDD:238075 46/102 (45%)
hif1aaNP_001295488.1 bHLH_SF 11..79 CDD:469605 37/77 (48%)
PAS 85..150 CDD:214512 34/82 (41%)
PAS 236..335 CDD:238075 42/98 (43%)
HIF-1 <519..541 CDD:463274 8/32 (25%)
HIF-1a_CTAD 683..716 CDD:430212
Blue background indicates that the domain is not in the aligned region.

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