DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and npas3

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	XP_012824098.2	Gene:	npas3 / 780104	XenbaseID:	XB-GENE-999791	Length:	949	Species:	Xenopus tropicalis

Alignment Length:	970	Identity:	233/970 - (24%)
Similarity:	372/970 - (38%)	Gaps:	301/970 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 APGSQPFVGAMLGPNMSSTGMQRYHPYHQQQPQDAFYRQRGSLLNVATPCRESRPWSYAYCYGYA 135
            |||:.|..||     ..|.|....|.::  .|..:.|:|||:          |||.|..
Frog    15 APGAPPEPGA-----ARSAGANGSHQHN--VPGVSSYQQRGA----------SRPISAC------ 56

  Fly   136 PTNTQPCQFSQFVDIEDFMNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASV 200
               ..||.....:.::..     ||||||||||.||.||...|.||:..|||.....:||||||:
Frog    57 ---PAPCPPDLNLSLQAL-----RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASI 113

  Fly   201 MRITIAFLKIREML-QFVP--SLRDCNDDIKQDIETAEDQQEVKP--------KLEVGTEDWLNG 254
            :|:||::||:|:.. |..|  :||.........::....|:...|        :..:|:.
Frog   114 IRLTISYLKMRDFAGQGDPPWNLRIEGPPPNTSVKVIGSQRRRSPSSVAMDIFESHMGSH----- 173

  Fly   255 AEARELLKQTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSL 319
                  :.|::|||:..|:.||...|:||.|..|||:::::..|..:::|.|..||.|:.|.|.:
Frog   174 ------ILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSMFDYVHPGDHVEMAEQLGM 232

  Fly   320 KRE-----LAQKVKDE-------------------------PQQNSGVSTHHRDLFVRLKCTLTS 354
            |..     |:|...|:                         ||.||    ..|..|:|:|.|||.
Frog   233 KLPPGRGLLSQSANDDGASSASSSSQSETPEPVEATSPGILPQDNS----LERSFFIRMKSTLTK 293

  Fly   355 RGRSINIKSASYKVIHITGHLVV--------NAKGERL-LMAIGRPIPHPSNIEIPLGTSTFLTK 410
            ||  ::|||:.|||||:||.|.:        :..|:.: |:.:...:|.|:..|:.:....|:|:
Frog   294 RG--VHIKSSGYKVIHVTGRLRLRVSLSHGRSGAGQVMGLVVVAHALPPPTINEVRIDCHMFVTR 356

  Fly   411 HSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGK 475
            .:||:...|.::::.|.:..:..||:....:...|..|.|.:..:...:|:|||..|..||::.|
Frog   357 VNLDLNIIYCENRISDYMDLNAVDLMGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQK 421

  Fly   476 YGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQ------------------- 519
            .|||.|:.|.|||..:  ....::::.|||::|..|.|.....:||
Frog   422 NGGYIWVQSCATISINAKNATERNIIWVNYILSLQEYKDIPMDIAQLPHLPEKTSESSETSDSDS 486

  Fly   520 ---------QTAASEQKEQHHQAAE----TEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPL 571
                     :...|:.|..|.:.:|    ..|:|...:||::...|  |..::....||...:..
Frog   487 DSKDNSEDNENPKSDGKGNHSEQSEDHEPDHKQPGPHSDPDMNCDE--EGNSSSDACSEESEESE 549

  Fly   572 QLESEKAEKTIE---------------------------ETKTIATIPPVTATSTADQIKQLPES 609
            ..|..|||:.:|                           |::|....|...::.:|...:...|.
Frog   550 DCELRKAEEVMEQGGLSALGGIGALDALGPMHIKVERYAESETDMRGPDSLSSDSAKDSESGDED 614

  Fly   610 NPYKQILQAELL------IKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPP 668
            .....:..|.:|      .:|.....||.....:.|||.||        |.::.:|:..|....|
Frog   615 EDDSGVRVAGVLNRHQRRKRRRRKGAGPCGGRRRRLSGGSS--------PGAIESSLGDPPRLLP 671

  Fly   669 LTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLF 733
            .|||||.. |                       ||:..|:|  :|::..|
Frog   672 STPPPTGA-C-----------------------SSSSVLKI--KTEMSEP--------------- 695

  Fly   734 ADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTAS 798
                     :..:.|....:......|..:| :|:|                      .......
Frog   696 ---------INFDNDSSIWNFPPNREISRNE-SPYS----------------------MTKPPTG 728

  Fly   799 GQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQH 863
            |:|: |||.||::||...      :.:.|.|.|||...|..:.                    ::
Frog   729 GEHF-SPSPSSSAAPPAL------HVSIPDSVLTPPGGAEGAG--------------------RN 766

  Fly   864 HPQHHDNSNSSSNIDPLFNYREESNDTSCSQHLHSPSITS---KSPEDSSLPSLCSPNSL 920
            .||....:..||  |||                 ||.:::   :.|..:|.||    |||
Frog   767 KPQFAGLATVSS--DPL-----------------SPPLSASPREKPPQTSGPS----NSL 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	29/52 (56%)
		PAS	256..392	CDD:279347	52/174 (30%)
		PAS	265..>317	CDD:238075	20/51 (39%)
		PAS	404..505	CDD:238075	30/102 (29%)
		PAS_3	417..502	CDD:285623	23/86 (27%)
npas3	XP_012824098.2	bHLH-PAS_NPAS3_PASD6	68..144	CDD:381575	36/80 (45%)
		PAS	169..230	CDD:214512	22/71 (31%)
		PAS_3	363..450	CDD:369881	23/86 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920