DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and SIM1

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	NP_001361698.1	Gene:	SIM1 / 6492	HGNCID:	10882	Length:	766	Species:	Homo sapiens

Alignment Length:	800	Identity:	201/800 - (25%)
Similarity:	328/800 - (41%)	Gaps:	184/800 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            ||||::|||.||.||...|.||:..|||.:...:||||||::|:|.::||:|  :.|...|.
Human     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMR--VVFPEGLG--- 61

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEAREL---LKQTMDGFLLVLSHEGDITYVSENVV 286
                   |.........|...||          |||   |.||:|||:.|::.:|.|.|:||...
Human    62 -------EAWGHSSRTSPLDNVG----------RELGSHLLQTLDGFIFVVAPDGKIMYISETAS 109

  Fly   287 EYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTH--HRDLFVRLK 349
            .:||:::::..|..|:||.|..||.|:...|:         ..:|..:..|..:  .|..|:|:|
Human   110 VHLGLSQVELTGNSIYEYIHPADHDEMTAVLT---------AHQPYHSHFVQEYEIERSFFLRMK 165

  Fly   350 CTLTSRGRSINIKSASYKVIHITGHLVVNAKGERL-----------LMAIGRPIPHPSNIEIPLG 403
            |.|..  |:..:....|||||.:|:|.:......:           |:|:|..:|..:..||.|.
Human   166 CVLAK--RNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLH 228

  Fly   404 TSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETS 468
            ::.|:.:.||||:..::|.::.:|.||.|:||::.:|:...||.|:..|......:|.|||..|.
Human   229 SNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTK 293

  Fly   469 RYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHH 531
            .||||.|:||:.|:.|.||||::  ..:|..:|.||||:::.|.|....||.|.:|:........
Human   294 YYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTS 358

  Fly   532 QAAETEKEPEKAADPEIIAQETKETVN-----TPIHTSELQAKPLQLESEKAEKTIEETKTIATI 591
            .:..|..:..|.|...:.:.::|...:     :..||...::   ..:|:.....:.:|.:...:
Human   359 SSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSES---DHDSQWGGSPLTDTASPQLL 420

  Fly   592 PPVTATSTADQIKQLPESNPYKQ------------ILQAELLIKRENHS---PGPRTITAQLLSG 641
            .|.....:     |...|..|:|            :..:.|:.:|..|:   .|.|....:...|
Human   421 DPADRPGS-----QHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLG 480

  Fly   642 SSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTP---LGVEPNLPPTTTA-------- 695
            :          |::..........|.|||        |.:|   ...|.::|...:.
Human   481 T----------PQAGREPWWGSRAALPLT--------KASPESREAYENSMPHIASVHRIHGRGH 527

  Fly   696 --TAAIISSSN--QQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLAS 756
              ..:::||.:  ...:...:.:.:..|....:.||....:.|..    .|:|||
Human   528 WDEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIETLIRATQ----QMIKEE---------- 578

  Fly   757 TNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQH------YQSPSSSST----S 811
            .|.:||.:..  ||.|..:.|                   |..:|      ||.|..:..    |
Human   579 ENRLQLRKAP--SDQLASING-------------------AGKKHSLCFANYQQPPPTGEVCHGS 622

  Fly   812 APSNTSSSN--------------NSYANSP--LSPL-TPNSTATASNPSHQQQQQHHNQQQQQQQ 859
            |.:|||..:              |.|.|||  ||.: :|||...:.:.....:...|:.....|.
Human   623 ALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDISPHQT 687

  Fly   860 QQQH----------HPQHHD 869
            ...|          |.|:.|
Human   688 AGDHPTVSPNCFGSHRQYFD 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	25/48 (52%)
		PAS	256..392	CDD:279347	45/151 (30%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	40/102 (39%)
		PAS_3	417..502	CDD:285623	32/86 (37%)
SIM1	NP_001361698.1	bHLH-PAS_SIM1	1..71	CDD:381581	31/80 (39%)
		PAS	88..>158	CDD:238075	22/78 (28%)
		PAS_3	243..329	CDD:369881	32/85 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..431		10/85 (12%)
		SIM_C	360..669	CDD:369005	65/369 (18%)
		Nuclear localization signal. /evidence=ECO:0000250	368..387		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..563		3/34 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910