DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and Hif3a

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	NP_001375441.1	Gene:	Hif3a / 64345	RGDID:	70332	Length:	664	Species:	Rattus norvegicus

Alignment Length:	776	Identity:	220/776 - (28%)
Similarity:	344/776 - (44%)	Gaps:	195/776 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 NNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPS 219
            :.|.||||||||||.|||:|||:..:|:..||........|||||:||:||::|::..:.    :
  Rat    11 STELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLC----A 71

  Fly   220 LRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSEN 284
            ..:.|                    :||.|    |........:.::||::||:.|||:.|:|||
  Rat    72 AGEWN--------------------QVGKE----GEPLDACYLKALEGFVMVLTAEGDMAYLSEN 112

  Fly   285 VVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLK 349
            |.::||:::::.:|..|:::.|.||..|:::||:.:..|::| |.|       :...|...:|:|
  Rat   113 VSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPRPSLSKK-KSE-------AATGRHFSLRMK 169

  Fly   350 CTLTSRGRSINIKSASYKVIHITGHL-----------VVNAKGE---RLLMAIGRPIPHPSNIEI 400
            .|||||||::|:|:|::||:|.:||:           ..:.:.|   :.|:.|...||||:::|.
  Rat   170 STLTSRGRTLNLKAATWKVLHCSGHMRAYKPPAQTSPAGSPRSEPPLQCLVLICEAIPHPASLEP 234

  Fly   401 PLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQG 465
            |||...||::|||||:|||.|:::.::.||||.||:..|.:...|..||:.:..:..::|||||.
  Rat   235 PLGRGAFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYEYIHALDSDAVSRSIHTLLSKGQA 299

  Fly   466 ETSRYRFLGKYGGYCWILSQATIVYDKLKPQ--SVVCVNYVISNLENKHEIYSLAQQTAASEQKE 528
            .|.:||||.:.|||.|..:|||:|.....||  |::||:::||.:|....:.||       ||.|
  Rat   300 VTGQYRFLARTGGYLWTQTQATVVSGGRGPQSESIICVHFLISRVEENGVVLSL-------EQTE 357

  Fly   529 QH----HQAAETEKE--PEKAADPEIIAQETKETVNTP-IHTSELQAKPLQLESEKAEKTIEETK 586
            ||    .|...:.|:  |..:.||.  |......::.| :..:.|.|.|.:..|....:.:   .
  Rat   358 QHTRRPPQLGTSSKKGIPGNSLDPP--APRILAFLHPPALSEASLAADPRRFCSPDLRRLM---A 417

  Fly   587 TIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKREN-H-----------------SPGPRT 633
            .|...||..||.:..|..:.|:| |....|..:|.:..|| |                 :..|.|
  Rat   418 PILDGPPTAATPSTPQAARRPQS-PLPADLPDQLAVGLENAHRLSTARKNKTMETDLDIAQDPDT 481

  Fly   634 ITAQLLS-----------GSSSGLRPEEKRPKSVTASVLRPSPAPPLTPP-PTAVLCKKTPLGVE 686
            :..::|:           .||..|....:||.. ||...|......|:|| |.|.|..:  .|.:
  Rat   482 LDLEMLAPYISMDDDFQLNSSEQLPKVHRRPPR-TARRPRARSFHGLSPPIPEATLLPR--WGSD 543

  Fly   687 PNL---------PPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTM 742
            |.|         |||...|              .:|:.:...|.::|             :||.:
  Rat   544 PRLNCSSSSKGDPPTAPLT--------------PRTRKRALAQSSED-------------KGLEL 581

  Fly   743 LKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSS 807
            |:.:|...|..|..                    |:.|||                      |.|
  Rat   582 LETKPPKRSPRLEP--------------------GSVLLP----------------------PLS 604

  Fly   808 SSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQHH 868
            .|..........|..   .|.:||..:.......||.....||....|         |::|
  Rat   605 LSFLLQGRQLPGNQP---DPRAPLVDSHEPLGLAPSLLSLYQHEETIQ---------PRNH 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	29/52 (56%)
		PAS	256..392	CDD:279347	47/149 (32%)
		PAS	265..>317	CDD:238075	20/51 (39%)
		PAS	404..505	CDD:238075	44/102 (43%)
		PAS_3	417..502	CDD:285623	36/86 (42%)
Hif3a	NP_001375441.1	bHLH-PAS_HIF3a_PASD7	12..74	CDD:381572	30/65 (46%)
		PAS	90..145	CDD:214512	20/54 (37%)
		PAS_3	251..338	CDD:369881	36/86 (42%)
		PHA03247	<360..633	CDD:223021	69/353 (20%)
		HIF-1	477..506	CDD:402842	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm46335
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23043
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1038
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.940