Protein Alignment sima and HIF3A

DIOPT Version :9

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_016882621.1
• Gene: HIF3A / 64344
• HGNCID: 15825
• Length: 755
• Species: Homo sapiens
• Alignment Length: 802
• Identity: 225/802 - (28%)
• Similarity: 358/802 - (44%)
• Gaps: 195/802 - (24%)

  Fly   116 VATPC---RESRPWSYAYCYGYAPTNTQPC----QFSQFVDIEDFMNNEKRKEKSRDAARCRRSK 173
            ::.||   |.|.|       |...|.:.|.    .||| .....:...|.||||||||||.|||:
Human    17 ISPPCAPTRNSHP-------GPGCTASPPAPPGWPFSQ-RGPGRWSTTELRKEKSRDAARSRRSQ 73

  Fly   174 ETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCNDDIKQDIETAEDQQ 238
            |||:..:|:..||........|||||:||:||::|::..:         |         .|.:..
Human    74 ETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRL---------C---------AAGEWN 120

  Fly   239 EVKPKLEVGTEDWLNGAEAREL----LKQTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQ 299
            :|             ||....|    || .::||::||:.|||:.|:||||.::||:::::.:|.
Human   121 QV-------------GAGGEPLDACYLK-ALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGH 171

  Fly   300 QIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLKCTLTSRGRSINIKSA 364
            .|:::.|.||..|:::||:.::.|:::..:.|.:        |...:|:|.|||||||::|:|:|
Human   172 SIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTE--------RCFSLRMKSTLTSRGRTLNLKAA 228

  Fly   365 SYKVIHITGHL-------VVNAKGE-------RLLMAIGRPIPHPSNIEIPLGTSTFLTKHSLDM 415
            ::||::.:||:       ..:..|.       :.|:.|...||||.::|.|||...||::|||||
Human   229 TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDM 293

  Fly   416 RFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYC 480
            :|||.||::.::.||||.||:..|.:...|..||:.:..:..::|||||..|.:||||.:.|||.
Human   294 KFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYL 358

  Fly   481 WILSQATIVYDKLKPQ--SVVCVNYVISNLENKHEIYSLAQQTAASEQKEQH-----HQAAETEK 538
            |..:|||:|.....||  |:|||:::||.:|....:.||       ||.|||     .:.|.::|
Human   359 WTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSL-------EQTEQHSRRPIQRGAPSQK 416

  Fly   539 EPEKAAD------PEIIAQETKETVNTP-IHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTA 596
            :.....|      |.|:|     .::.| :..:.|.|.|.:..|....:.:......|::....:
Human   417 DTPNPGDSLDTPGPRILA-----FLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPS 476

  Fly   597 TSTADQIKQLPESNPYKQILQAELLIKREN----HSPGP--------------RTITAQLLSGSS 643
            |..|.:..|    :|....|..||.:..||    .:.|.              |.:..:||:..:
Human   477 TPLATRHPQ----SPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQMRKLKLRLLTTGT 537

  Fly   644 SGLRPEEKRPKSVTASVLRPSP----APPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSN 704
                 |.:...:.|::.:.|||    .||..||..|     ..|.:| .|.|..:.......:::
Human   538 -----ELRSDGAGTSAKVHPSPRLILLPPSCPPQDA-----DALDLE-MLAPYISMDDDFQLNAS 591

  Fly   705 QQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFS 769
            :||..|....|....:|   .::.|        .||:....||.
Human   592 EQLPRAYHRPLGAVPRP---RARSF--------HGLSPPALEPS--------------------- 624

  Fly   770 DMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSN----TSSSNNSYANSPLSP 830
                      |||. ..|....:||:.:.|    .||:||..|.:.    ..||.:......|..
Human   625 ----------LLPR-WGSDPRLSCSSPSRG----DPSASSPMAGARKRTLAQSSEDEDEGVELLG 674

  Fly   831 LTPNSTATASNPSHQQQQQHHN 852
            :.|        |......:|.|
Human   675 VRP--------PKRSPSPEHEN 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	29/52 (56%)
		PAS	256..392	CDD:279347	47/153 (31%)
		PAS	265..>317	CDD:238075	20/51 (39%)
		PAS	404..505	CDD:238075	46/102 (45%)
		PAS_3	417..502	CDD:285623	38/86 (44%)
HIF3A	XP_016882621.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm42186
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1038
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.940