Protein Alignment sima and arnt2

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_009301213.1
• Gene: arnt2 / 64277
• ZFINID: ZDB-GENE-001207-3
• Length: 738
• Species: Danio rerio
• Alignment Length: 870
• Identity: 190/870 - (21%)
• Similarity: 312/870 - (35%)
• Gaps: 259/870 - (29%)

  Fly   141 PCQFSQFVDIEDFMNNEKR--KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRI 203
            |.:||:: |.:....:::|  :|...:..|.||:|.|:...|||..:|..:....:.||.:::|:
Zfish    60 PSKFSRY-DDDQIPGDKERYARENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRM 123

  Fly   204 TIAFLKIREMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGF 268
            .::.:|         |:|...:       |:.| ...||       .:|...|.:.|:.:..|||
Zfish   124 AVSHMK---------SMRGTGN-------TSTD-GAYKP-------SFLTEQELKHLILEAADGF 164

  Fly   269 LLVLSHE-GDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLK------RELAQK 326
            |.|::.| |.:.|||::|...|...:.:..|..::|..|..|..:::|.||..      |.|..|
Zfish   165 LFVVAAETGRVIYVSDSVTPVLNHPQSEWFGSTLFEQVHPDDVDKLREQLSTSENSMTGRILDLK 229

  Fly   327 ---VKDEPQQNS-----GVSTHHRDLFVRLKC--------------TLTSRGRS----INIKSAS 365
               ||.|.||:|     |   ..|....|::|              ::..|.|:    .....|.
Zfish   230 TGTVKKEGQQSSMRMCMG---SRRSFICRMRCGSAPLDHISLNRLSSMRKRYRNGLGPSKEGEAQ 291

  Fly   366 YKVIHITGHL---------------VVNAKGERLLMAIGR------PIPHPSN-IEIPLGTSTFL 408
            |.|:|.||::               ......:..|:||||      |:....| :.:|   :.||
Zfish   292 YSVVHCTGYIKAWPPAGMTIPDEDTEAGQTSKYCLVAIGRLQVTSSPVSMDMNGLSVP---TEFL 353

  Fly   409 TKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLS-KGQGETSRYRF 472
            ::|:.|...|:||.:..:::||.|:|||...:....|..|...|..:|:.|:. |||..:..|||
Zfish   354 SRHNSDGIITFVDPRCINVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRF 418

  Fly   473 LGKYGGYCWILSQATIVYDKLKPQS-----VVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQ 532
            ..|  ...|:|.: |..:....|.|     ::|.|..:..|                    |..|
Zfish   419 RMK--NREWMLIR-TSSFTFQNPYSDEIEYIICTNTNVKQL--------------------QQQQ 460

  Fly   533 AAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTAT 597
            .||.|...........::|.....|:..:|.|   .|.:    :|.|....:.:........|..
Zfish   461 QAELEVHQRDGLTAYDLSQVPVSGVSAGVHES---GKSI----DKTESLFSQERDPRFSDIYTGI 518

  Fly   598 STADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLR 662
            ||:::...:|.|                       |...|.|....|..:|... .||.::||:.
Zfish   519 STSEKKMMVPSS-----------------------TSGGQQLYSQGSPFQPGHS-GKSFSSSVIH 559

  Fly   663 PSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSK 727
                              .| ||. ::..|..:....:|..::|:...|.:...|  :|
Zfish   560 ------------------VP-GVN-DIQSTAGSAGQNLSQISRQINTGQVSWSGN--RP------ 596

  Fly   728 GFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTT 792
                                                   |||       |...:|...|...|:.
Zfish   597 ---------------------------------------PFS-------GQQQIPAQSNKAQSSP 615

  Fly   793 CSTTASGQHYQSPSS-SSTSAPSNTSSSNNSYANSPLSPLTPNSTA-TASNPSHQQQQQHHNQQQ 855
            ....:|..:...||| |..|:|:.:|.|.|:|:|     |...:|| ..|..|.|...|...:..
Zfish   616 FGIGSSHSYQADPSSYSPLSSPATSSPSGNAYSN-----LANRNTAFDVSGESSQSGGQFQGRPS 675

  Fly   856 Q--QQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDSSLPSLCSPN 918
            :  .|.|.|||.|...        ||               |.|:.:..::..:| .||   .|.
Zfish   676 EVWSQWQSQHHSQQAG--------DP---------------HPHTQASQTEVFQD-MLP---MPG 713

  Fly   919 SLTQ-EDDFSFEAFAMRAPYIPIDD 942
            ..|| ..:::.|.||....:.|..:
Zfish   714 DPTQGTTNYNIEDFADLGMFPPFSE 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	15/58 (26%)
		PAS	256..392	CDD:395786	47/189 (25%)
		PAS	265..>317	CDD:238075	17/52 (33%)
		PAS	404..505	CDD:238075	32/106 (30%)
arnt2	XP_009301213.1	bHLH-PAS_ARNT	75..139	CDD:381517	18/79 (23%)
		PAS	152..258	CDD:395786	33/108 (31%)
		PAS_11	351..451	CDD:464214	31/102 (30%)