Protein Alignment sima and ahrra

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001030342.2
• Gene: ahrra / 641291
• ZFINID: ZDB-GENE-051018-1
• Length: 550
• Species: Danio rerio
• Alignment Length: 519
• Identity: 113/519 - (21%)
• Similarity: 182/519 - (35%)
• Gaps: 150/519 - (28%)

  Fly   157 EKRK------EKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQ 215
            :|:|      |||..:.|.|.....|: ..|:..||...|.|.:|||.||:|:::::|:|:....
Zfish    19 QKQKPAALMSEKSNPSKRHRERLNAEL-ERLAELLPFGPDTVCKLDKLSVLRLSVSYLRIKSFCS 82

  Fly   216 FVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITY 280
            .:.....|      :.:|:::||:.....          ....:||.:::.||.||:|.:|.:.|
Zfish    83 VLAQENPC------ETQTSKNQQDTPAAC----------VPESQLLLESLAGFALVVSGDGMVFY 131

  Fly   281 VSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEAL--------------SLKRELAQKVKDEP 331
            .|..:.:|||..:.|.:.|.:::|.|..|..|.:..|              ....|.|.....:.
Zfish   132 ASSTIADYLGFHQTDVMHQNVFDYIHVDDRQEFRRQLHWAMNPPNPEAQSSGTAEEFAVSSLFQS 196

  Fly   332 QQNSGVSTH-----HRDLFVRLKCTLTSRGRSINIK-SASYKVIH------ITGHLVVNA----- 379
            .|.:||...     .|...:|::|.|.|....:.:: ....|.:|      ::|..:..|
Zfish   197 DQPAGVPPELSCFLSRCFILRVRCLLDSTSGFLTMQFQGQLKFLHGQRRRAVSGAALPPALALFC 261

  Fly   380 -------KGERLLMAIGR------PIPHPSNIEIPL---GTSTFL-------------------- 408
                   .|..|.|...:      |:|..::.|.||   ||.|..
Zfish   262 VAVPLLPSGPDLKMRSRQRGPGALPVPQHTDREDPLRRAGTHTLFSRDAVKRRTEGLFAADQPQS 326

  Fly   409 ----TKHSLDM---RFTYVDDKMHDLLGYSPKDLLDTSLFSCQ-HGAD----SERLMATFK---- 457
                |..::||   |.|:. .|.....|||..:.::   ||.| ||.|    :..|....|
Zfish   327 VWPRTAPAVDMTARRHTHY-GKPSRSAGYSRAECVE---FSFQPHGDDYNTHTHLLEPQVKLEPD 387

  Fly   458 SVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKH----EIYSLA 518
            |....|.|...||   ..:||.|          ::.......|..|      |.|    |.|:.|
Zfish   388 SDCENGSGACGRY---NTHGGAC----------ERYNTHGAACERY------NTHGAACERYNSA 433

  Fly   519 -----------------QQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSE 565
                             ||.:....|..:.....|...|.|.......|..|..|..|.::|::
Zfish   434 GGHTHMGAQVKLEDGFGQQFSCQRMKPPYAGHCYTPPRPLKCVLNREAASGTLNTHCTDVYTAD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	20/62 (32%)
		PAS	256..392	CDD:395786	37/179 (21%)
		PAS	265..>317	CDD:238075	17/51 (33%)
		PAS	404..505	CDD:238075	29/136 (21%)
ahrra	NP_001030342.2	None