Protein Alignment sima and bmal2

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_571653.3
• Gene: bmal2 / 58099
• ZFINID: ZDB-GENE-000509-2
• Length: 631
• Species: Danio rerio
• Alignment Length: 427
• Identity: 112/427 - (26%)
• Similarity: 190/427 - (44%)
• Gaps: 75/427 - (17%)

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            :|......:.||.|...:..||:|.:|.......:|||.:|:|:.:..||         ||:...
Zfish    91 REPHSQIEKRRRDKMNNLIDELAAMIPTCNPMSRKLDKLTVLRMAVQHLK---------SLKGAT 146

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLS-HEGDITYVSENVVEY 288
            ....        :...||.       :|...|.:.|:.:..||||.|:. ..|.|.:|||:|.:.
Zfish   147 SSFA--------EANYKPA-------FLPDDELKHLVLRAADGFLFVVGCDRGKIVFVSESVSKT 196

  Fly   289 LGITKIDTLGQQIWEYSHQCDHAEIKEALS----------LKRELAQKVKDEPQQNSG--VSTHH 341
            |..::.:.:||.:::|.|..|..::||.||          :..:...:|:.|....|.  .|...
Zfish   197 LNYSRTELIGQSLFDYVHPKDIGKVKEQLSASELYPRERLIDAKTGLQVQAELPVGSARLCSGAR 261

  Fly   342 RDLFVRLKCT-LTSR-------GRSINIKSASYKVIHITGHL------VVNAKGE---------- 382
            |..|.|:|.. :|.:       |.|...:|..|..:|.||::      .:..:||
Zfish   262 RSFFCRMKYNKITVKEEKDFQAGASKKKESQRYCTVHCTGYMRTWPTRQLATEGEAEADKESSHF 326

  Fly   383 RLLMAIGRPIPH---PSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQ 444
            ..|:|:||..||   .:|.||.:..:.|:|::::|.:||:||.:...:|||.|::||.||.:...
Zfish   327 SCLVAMGRVHPHTLPQANGEIKVKPTEFVTRYAMDGKFTFVDQRATTILGYLPQELLGTSCYEYF 391

  Fly   445 HGADSERLMATFKSVL-SKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKP-----QSVVCVNY 503
            |..|...|....:.|| ||.:.||:.|:|..|.|.:..:.||   .:..:.|     :.:|..|.
Zfish   392 HLDDLPHLAERHRKVLRSKEKIETNCYKFKTKSGSFVNLQSQ---WFSFINPWTKEVEYIVSTNT 453

  Fly   504 VISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEP 540
            |:|...|.......|:|.::|:..|.  .|.::::.|
Zfish   454 VVSGKSNPGGSGDKAEQPSSSKASED--DAKKSQQVP 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	15/55 (27%)
		PAS	256..392	CDD:395786	45/172 (26%)
		PAS	265..>317	CDD:238075	19/52 (37%)
		PAS	404..505	CDD:238075	33/106 (31%)
bmal2	NP_571653.3	None