Protein Alignment sima and bmal1a

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_571652.1
• Gene: bmal1a / 58098
• ZFINID: ZDB-GENE-000509-1
• Length: 626
• Species: Danio rerio
• Alignment Length: 690
• Identity: 162/690 - (23%)
• Similarity: 261/690 - (37%)
• Gaps: 205/690 - (29%)

  Fly   138 NTQPCQFSQFVDIEDFMNNEKRKEKSRD---------------AARCRRSKETEIFMELSAALPL 187
            :|...|...| ..:|.|:.:|.|...||               ..:.||.|......||::.:|.
Zfish    42 STTEYQIDGF-SFDDSMDTDKDKTLGRDEQQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPT 105

  Fly   188 KTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWL 252
            ......:|||.:|:|:.:..:|         :||...:..        .:...||.       :|
Zfish   106 CNAMSRKLDKLTVLRMAVQHMK---------TLRGATNPY--------TEANYKPA-------FL 146

  Fly   253 NGAEARELLKQTMDGFLLVLS-HEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEA 316
            :..|.:.|:.:..||||.|:. ..|.|.:|||:|.:.|..|:.|.:||.:::|.|..|.|::||.
Zfish   147 SDDELKHLILRAADGFLFVVGCDRGKILFVSESVYKILNYTQNDLIGQSLFDYLHPKDIAKVKEQ 211

  Fly   317 LS------------LKRELAQKVKDEPQQNSGVSTHHRDLFVRLKCTLTS-------RGRSINIK 362
            ||            .|..|..|....|..:...|...|..|.|:||...|       ...:.:.|
Zfish   212 LSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKMEDKDFPSTCSKK 276

  Fly   363 SA---SYKVIHITGHL--------------VVNAKGERL--LMAIGRPIPH----PSNIEIPLGT 404
            .|   |:..||.||:|              ..:.:|..|  |:||||..||    |.|.:|.:..
Zfish   277 KADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHPHIVPQPMNGDIRVKP 341

  Fly   405 STFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLS-KGQGETS 468
            :.::::|::|.:|.:||.:...:|.|.|::||.||.:...|..|...|....:.||. :.:..|:
Zfish   342 TEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSFYEYFHQDDIGHLAECHRQVLQMREKISTN 406

  Fly   469 RYRFLGKYGGYCWILSQATIVYDKLKP-----QSVVCVNYVISN--LENKHEIYSLAQQTAASEQ 526
            .|:|..|.|.:..:.|:   .:..:.|     :.:|..|.|:|.  ||.....||   |||:|.|
Zfish   407 CYKFKIKDGSFITLRSR---WFSFMNPWTKEVEYIVSTNTVVSGSMLEGADPSYS---QTASSPQ 465

  Fly   527 KEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAK-PLQLESEKAEKTIEETKTIAT 590
                                         ::::.:.:.:...| |||:              :..
Zfish   466 -----------------------------SMDSVLTSGDGGGKRPLQI--------------VPG 487

  Fly   591 IPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKS 655
            ||..|... |.:|.::        |.:..:.|:|...|           |.||.|     ..|.:
Zfish   488 IPGGTRAG-AGKIGRM--------IAEEVMEIQRIRGS-----------SPSSCG-----SSPLN 527

  Fly   656 VTASVLRPSPAPPLTPPPTAVLC----KKTPLGVEPNLPPTTTATAAII---------------- 700
            :||           ||||..  |    ||...|..|:||     :|.|:
Zfish   528 ITA-----------TPPPDT--CSPGGKKIQNGGTPDLP-----SAGIVPGPDSIGYPYSNNSLM 574

  Fly   701 -SSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRG 739
             .:|:..:.|.::....:|......|:.....|.||.|.|
Zfish   575 SDNSHLSIDIMEEPGSSSPSNDEAAMAVIMSLLEADAGLG 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	15/71 (21%)
		PAS	256..392	CDD:395786	52/174 (30%)
		PAS	265..>317	CDD:238075	22/52 (42%)
		PAS	404..505	CDD:238075	26/106 (25%)
bmal1a	NP_571652.1	bHLH-PAS_ARNTL_PASD3	71..134	CDD:381444	14/71 (20%)
		PAS	153..212	CDD:214512	23/58 (40%)
		KinE	170..>423	CDD:444511	72/252 (29%)
		PAS_11	343..446	CDD:464214	27/105 (26%)