Protein Alignment sima and AHRR

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001364165.1
• Gene: AHRR / 57491
• HGNCID: 346
• Length: 697
• Species: Homo sapiens
• Alignment Length: 770
• Identity: 151/770 - (19%)
• Similarity: 253/770 - (32%)
• Gaps: 249/770 - (32%)

  Fly   161 EKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCND 225
            |||..:.|.|.....|: ..|::.||...|.:::|||.||:|:::::|:::...|.|
Human    28 EKSNPSKRHRDRLNAEL-DHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVV-------- 83

  Fly   226 DIKQDIETAEDQQEVKPKL---EVGTEDWLNGAEARE--LLKQTMDGFLLVLSHEGDITYVSENV 285
                     ::|...:|..   ..|....|.|:...|  ||.::::||.||:|.||.|.|.|..:
Human    84 ---------QEQSSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATI 139

  Fly   286 VEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEP------------------Q 332
            |:|||..:.|.:.|.|::|.|..|..:....|....:..|.|..:|                  :
Human   140 VDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQE 204

  Fly   333 QNSGVSTHH-----RDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERLLMAIGRPI 392
            ..:|..|.:     |....|::|.|.|                .:|.|.:..:| :|....|:..
Human   205 WGTGTPTEYSAFLTRCFICRVRCLLDS----------------TSGFLTMQFQG-KLKFLFGQKK 252

  Fly   393 PHPSNIEIPLGTSTF------LTKHSLDMRFTYVDDKMHD-LLGYSPKDLLDTSLFSCQHGADSE 450
            ..||...:|...|.|      |...:.:|       ||.. ||...|:  .||:.     .||:
Human   253 KAPSGAMLPPRLSLFCIAAPVLLPSAAEM-------KMRSALLRAKPR--ADTAA-----TADA- 302

  Fly   451 RLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHEIY 515
            ::.||.....|:..|                            ||      ||.......:..:.
Human   303 KVKATTSLCESELHG----------------------------KP------NYSAGRSSRESGVL 333

  Fly   516 SLAQQTAASEQKEQHHQAAETEKEPEKA------ADPEIIAQETKETVNTPIHTSELQAKPLQLE 574
            .|.:||          .|....:.|.:|      ..|:::                     |..:
Human   334 VLREQT----------DAGRWAQVPARAPCLCLRGGPDLV---------------------LDPK 367

  Fly   575 SEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPR-----TI 634
            ....::..|:.:.::....||.                          :||  :|||.     |.
Human   368 GGSGDREEEQHRMLSRASGVTG--------------------------RRE--TPGPTKPLPWTA 404

  Fly   635 TAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAI 699
            ......|:...|:|.:..|.|     |||.|.....|.|    |.:......|...|.:.:.:|.
Human   405 GKHSEDGARPRLQPSKNDPPS-----LRPMPRGSCLPCP----CVQGTFRNSPISHPPSPSPSAY 460

  Fly   700 ISSSNQQLQIAQQTQL--------------QNPQQPAQDMSKGFCSLFADDGRGLTMLKEE---- 746
            .|.:::.::...:.|:              |.||..||        .||..|..:..:|.:
Human   461 SSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQ--------RFATRGYPMEDMKLQGVPM 517

  Fly   747 -PDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDI--NSLDSTTCSTTASGQHYQSPSSS 808
             |.||   ...|..:.:...........|....| :|..:  .:.|.:..:|..:..|.::...|
Human   518 PPGDL---CGPTLLLDVSIKMEKDSGCEGAADGC-VPSQVWLGASDRSHPATFPTRMHLKTEPDS 578

  Fly   809 ST-------------SAPSNTSSSNNSYANSPLSP-----LTPNSTATASNPSHQ 845
            ..             :.|...:::..|...:|..|     |.|......|.|.||
Human   579 RQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQ 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	17/54 (31%)
		PAS	256..392	CDD:395786	39/160 (24%)
		PAS	265..>317	CDD:238075	20/51 (39%)
		PAS	404..505	CDD:238075	21/107 (20%)
AHRR	NP_001364165.1	bHLH-PAS_AhRR	26..85	CDD:381441	19/74 (26%)
		PAS	113..176	CDD:214512	23/62 (37%)