DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and npas3

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	XP_017207251.1	Gene:	npas3 / 570491	-ID:	-	Length:	979	Species:	Danio rerio

Alignment Length:	909	Identity:	218/909 - (23%)
Similarity:	368/909 - (40%)	Gaps:	229/909 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GSFYNGPAPGSQPFVGAMLGPNMSSTGMQRYHPYHQQQPQDAFYRQRGSLLNVATPCRESRPWSY 128
            |:...|..|.:....||..|...:..|:.   .|.|.:|    |.:|.:   .|:.|..:|| ..
Zfish    19 GAGGGGGMPAASRVPGATNGNPQNVQGLT---SYQQSEP----YWERSA---NASSCSAARP-KT 72

  Fly   129 AYCYGYAPTNTQPCQFSQFVDIEDFMNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVN 193
            .:..|...|::...|             ..||||||||||.||.||...|.||:..|||.....:
Zfish    73 LHLGGQQHTSSPWLQ-------------ALRKEKSRDAARSRRGKENFEFYELAKMLPLPAAITS 124

  Fly   194 QLDKASVMRITIAFLKIREML-QFVP--SLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGA 255
            ||||||::|:||::||:|:.. |..|  :||.........::....|:...|           .|
Zfish   125 QLDKASIIRLTISYLKMRDFANQGDPPWNLRIEGPPPNTSVKAIGSQRRRSP-----------NA 178

  Fly   256 EARELLK--------QTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAE 312
            .|.::.:        |::|||:..|:.||...|:||.|..|||:::::..|..:::|.|..||.|
Zfish   179 MASDIFEPHLGSHILQSLDGFVFALNKEGRFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVE 243

  Fly   313 IKEALSLKRE-----LAQKVKDEPQQNSGVSTHH----------------------RDLFVRLKC 350
            :.|.|.:|..     |:|....|...:|..|:.|                      |..|:|:|.
Zfish   244 MAEQLGMKLPPGRGLLSQGTGAEDGASSASSSSHSETPEPVESSSPSLLSPDNTLERSFFIRMKS 308

  Fly   351 TLTSRGRSINIKSASYKVIHITGHLVVNAKGERLLMA----------------IGRPIPHPSNIE 399
            |||.||  ::|||:.||||||||.|       |:.||                :...:|.|:..|
Zfish   309 TLTKRG--VHIKSSGYKVIHITGRL-------RIRMALTHSRSVPNQIMGMVVVAHALPPPTINE 364

  Fly   400 IPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQ 464
            :.:....|:|:.::|:...|.::::.|.:..:|.|::....:...|..|.|.:..:...:|:|||
Zfish   365 VRIDCQMFVTRVNMDLNIVYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRQSHLDLLNKGQ 429

  Fly   465 GETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQK 527
            ..|..||::.|.|||.||.|.|||..:  ....::::.||||:||.|.|.....:||.....|:.
Zfish   430 CVTKYYRWIQKNGGYIWIQSSATIAINAKNANEKNIIWVNYVLSNPEYKDTPMDIAQLPNLPEKA 494

  Fly   528 EQHHQAAETEKE--------------------PEKAADPEIIAQETKETVNTPIHTSELQAKPLQ 572
            .:..:.:::|.:                    .|.:.|||  |...|:|           .:|.:
Zfish   495 SESSETSDSESDSKENSEDNENSKSDGKGNQSSENSEDPE--ADSKKQT-----------GRPPE 546

  Fly   573 LESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQ 637
            .|..:.|:....:.      |.:..|. |.::.......:|:.....|.||.|::..|    ..:
Zfish   547 QEMRRQEEGDSSSN------PESQDSD-DSLEPSDCETDHKEGRLGGLHIKVEHYGDG----EME 600

  Fly   638 LLSGSSSGLRPEEKRPKSVTASV-----------------------------------LRPSPAP 667
            .|..|||....|::....|...|                                   ||.||:.
Zfish   601 GLQDSSSSCSSEDEEEDDVEDIVKDCNSGGELSGPAMSKHQKRKKRRKKQKWDGSRQRLRLSPSA 665

  Fly   668 PLTPPPTAV---LCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGF 729
            ..||.|.::   |..:.||.:.|:  ||:::...|.:..::.:.....:.:.| ..|.:::|:
Zfish   666 AATPSPGSLDPTLGDQPPLLLPPS--PTSSSVLKIKTEMSEPINFDNDSSIWN-YPPNREISR-- 725

  Fly   730 CSLFADDGRGLTMLKEEPDDLS--HHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTT 792
                          .|.|..::  |....:        .|.:.:.|.:..:.|.|..
Zfish   726 --------------NESPYSMTKPHDTFPS--------PPPAGLQVSIPDSVLTPPG-------- 760

  Fly   793 CSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNP-------SHQQQQQ 849
               ..||...:.|:.:..|:..|.:::..|.:::....|.|.|::|.::|       |.:.:||
Zfish   761 ---AESGGGSRKPNFNGNSSSGNNNNAATSVSSATSGSLVPPSSSTTADPLSPPLSASPRDKQQ 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	29/52 (56%)
		PAS	256..392	CDD:279347	54/186 (29%)
		PAS	265..>317	CDD:238075	20/51 (39%)
		PAS	404..505	CDD:238075	30/102 (29%)
		PAS_3	417..502	CDD:285623	24/86 (28%)
npas3	XP_017207251.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592824
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850