DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and sim1b

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	NP_001153057.1	Gene:	sim1b / 566656	ZFINID:	ZDB-GENE-041210-5	Length:	586	Species:	Danio rerio

Alignment Length:	733	Identity:	188/733 - (25%)
Similarity:	297/733 - (40%)	Gaps:	187/733 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            ||||:.|||.||.||...|.||:..|||.:...:||||||::|:|.::||:|  |.|...|.:..
Zfish     2 KEKSKTAARTRREKENSEFYELAKMLPLPSAITSQLDKASIIRLTSSYLKMR--LVFPQGLGEVW 64

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLK-------QTMDGFLLVLSHEGDITYVS 282
            .      :....:....|..|:|:          .||:       ||:|||:.|::.:|.|.|:|
Zfish    65 G------QAGRTRSGENPSHELGS----------HLLQVIISKMLQTLDGFIFVVAADGKIMYIS 113

  Fly   283 ENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHH---RDL 344
            |....:||:::::..|..|:||.|..||.|:...|:          .:|..:|.....:   |..
Zfish   114 ETASVHLGLSQVELTGNSIYEYVHPADHDEMAAVLT----------PQPSYHSHFVQEYEVERSF 168

  Fly   345 FVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNA--------------KGERLLMAIGRPIPHP 395
            |:|:||.|..  |:..:.|..|||||.:|:|.:..              .|   |:|:|..:|..
Zfish   169 FLRMKCVLAK--RNAGLTSGGYKVIHCSGYLKIRQFSLDASPFDGCYQNVG---LVAVGHTLPPS 228

  Fly   396 SNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVL 460
            :..||.|.::.|:.:.||||:..::|.::.||.||.|:||::.:|:...|..||..|......:|
Zfish   229 AVTEIKLHSNMFMFRASLDMKLIFLDSRVSDLTGYEPQDLIEKTLYHHVHCCDSFHLRCAHHLLL 293

  Fly   461 SKGQGETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAA 523
            .|||..|..||||.|.||:.|:.|.||||::  ..:|..:|.||||:::.|.|..|.||.|
Zfish   294 VKGQVTTKYYRFLSKRGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLILSLDQ---- 354

  Fly   524 SEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTI 588
                          ..|.|.|.|  .|..:.:|     ||:..::|.|         ....::..
Zfish   355 --------------LNPRKPAFP--YANHSDKT-----HTTNSRSKIL---------LSHYSQQF 389

  Fly   589 ATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRP 653
            ::.||..:.|..|                     .:...||         |:.|:|..|.:  |.
Zfish   390 SSFPPDRSDSDHD---------------------SQWEDSP---------LTDSASPQRLD--RS 422

  Fly   654 KSVTASVLRPSPAPPLTPPPTAVLCKK--TPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQ 716
            .||..|         |........|.:  |||.   |......|.||     ||.........|.
Zfish   423 DSVCFS---------LAQSDVMQSCSQTHTPLF---NRDGWWDARAA-----NQHSHAVWDEDLS 470

  Fly   717 NPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLL 781
            :....:.|.::             ::::..|:                              .:.
Zfish   471 SSSAQSADGAQ-------------SLIRAAPE------------------------------LIK 492

  Fly   782 PEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQ 846
            .|:.:..|.::.|..:|.:|.......|.::.|..||..:...:.|||...|....|.::||.:.
Zfish   493 VEEAHMRDYSSSSLFSSARHRDGDPDGSPASLSALSSPGSDRPSQPLSASPPALETTHTHPSLRA 557

  Fly   847 QQQHHNQQQQQQQQQQHH 864
            ...|::.....|.....|
Zfish   558 YSAHYDINTHFQSSTTAH 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	25/48 (52%)
		PAS	256..392	CDD:279347	45/159 (28%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	41/102 (40%)
		PAS_3	417..502	CDD:285623	33/86 (38%)
sim1b	NP_001153057.1	HLH	2..52	CDD:238036	26/49 (53%)
		PAS	92..>149	CDD:279347	21/56 (38%)
		PAS	92..148	CDD:214512	21/55 (38%)
		PAS	237..336	CDD:238075	38/98 (39%)
		PAS_3	251..337	CDD:285623	33/85 (39%)
		SIM_C	357..>498	CDD:284122	39/248 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910