Protein Alignment sima and sim1b

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001153057.1
• Gene: sim1b / 566656
• ZFINID: ZDB-GENE-041210-5
• Length: 586
• Species: Danio rerio
• Alignment Length: 733
• Identity: 188/733 - (25%)
• Similarity: 297/733 - (40%)
• Gaps: 187/733 - (25%)

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            ||||:.|||.||.||...|.||:..|||.:...:||||||::|:|.::||:|  |.|...|.:..
Zfish     2 KEKSKTAARTRREKENSEFYELAKMLPLPSAITSQLDKASIIRLTSSYLKMR--LVFPQGLGEVW 64

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLK-------QTMDGFLLVLSHEGDITYVS 282
            .      :....:....|..|:|:          .||:       ||:|||:.|::.:|.|.|:|
Zfish    65 G------QAGRTRSGENPSHELGS----------HLLQVIISKMLQTLDGFIFVVAADGKIMYIS 113

  Fly   283 ENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHH---RDL 344
            |....:||:::::..|..|:||.|..||.|:...|:          .:|..:|.....:   |..
Zfish   114 ETASVHLGLSQVELTGNSIYEYVHPADHDEMAAVLT----------PQPSYHSHFVQEYEVERSF 168

  Fly   345 FVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNA--------------KGERLLMAIGRPIPHP 395
            |:|:||.|..  |:..:.|..|||||.:|:|.:..              .|   |:|:|..:|..
Zfish   169 FLRMKCVLAK--RNAGLTSGGYKVIHCSGYLKIRQFSLDASPFDGCYQNVG---LVAVGHTLPPS 228

  Fly   396 SNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVL 460
            :..||.|.::.|:.:.||||:..::|.::.||.||.|:||::.:|:...|..||..|......:|
Zfish   229 AVTEIKLHSNMFMFRASLDMKLIFLDSRVSDLTGYEPQDLIEKTLYHHVHCCDSFHLRCAHHLLL 293

  Fly   461 SKGQGETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAA 523
            .|||..|..||||.|.||:.|:.|.||||::  ..:|..:|.||||:::.|.|..|.||.|
Zfish   294 VKGQVTTKYYRFLSKRGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLILSLDQ---- 354

  Fly   524 SEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTI 588
                          ..|.|.|.|  .|..:.:|     ||:..::|.|         ....::..
Zfish   355 --------------LNPRKPAFP--YANHSDKT-----HTTNSRSKIL---------LSHYSQQF 389

  Fly   589 ATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRP 653
            ::.||..:.|..|                     .:...||         |:.|:|..|.:  |.
Zfish   390 SSFPPDRSDSDHD---------------------SQWEDSP---------LTDSASPQRLD--RS 422

  Fly   654 KSVTASVLRPSPAPPLTPPPTAVLCKK--TPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQ 716
            .||..|         |........|.:  |||.   |......|.||     ||.........|.
Zfish   423 DSVCFS---------LAQSDVMQSCSQTHTPLF---NRDGWWDARAA-----NQHSHAVWDEDLS 470

  Fly   717 NPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLL 781
            :....:.|.::             ::::..|:                              .:.
Zfish   471 SSSAQSADGAQ-------------SLIRAAPE------------------------------LIK 492

  Fly   782 PEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQ 846
            .|:.:..|.::.|..:|.:|.......|.::.|..||..:...:.|||...|....|.::||.:.
Zfish   493 VEEAHMRDYSSSSLFSSARHRDGDPDGSPASLSALSSPGSDRPSQPLSASPPALETTHTHPSLRA 557

  Fly   847 QQQHHNQQQQQQQQQQHH 864
            ...|::.....|.....|
Zfish   558 YSAHYDINTHFQSSTTAH 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	29/55 (53%)
		PAS	256..392	CDD:395786	45/159 (28%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	41/102 (40%)
sim1b	NP_001153057.1	bHLH-PAS_SIM1	1..70	CDD:381581	31/75 (41%)
		PAS	92..148	CDD:214512	21/55 (38%)
		PAS_11	99..205	CDD:464214	35/117 (30%)
		PAS_3	251..337	CDD:430001	33/85 (39%)
		SIM_C	357..>498	CDD:461963	39/248 (16%)