Protein Alignment sima and npas1

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001315312.1
• Gene: npas1 / 559419
• ZFINID: ZDB-GENE-060503-934
• Length: 770
• Species: Danio rerio
• Alignment Length: 637
• Identity: 169/637 - (26%)
• Similarity: 286/637 - (44%)
• Gaps: 116/637 - (18%)

  Fly   159 RKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQ-----FVP 218
            ||||||:|||.||.||...|.||:..|||.....:||||||::|:||::|.:|....     :.|
Zfish    37 RKEKSRNAARSRRGKENFEFFELAKMLPLPGAITSQLDKASIIRLTISYLHMRHFASQGDPPWSP 101

  Fly   219 SLRDCNDDIK-----QDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDI 278
            .:...|:..|     ..:.|...:|.:             ||.    |.|::|||:.|:|.||..
Zfish   102 LMEGENNCSKVRRTSHSLVTDIFEQHL-------------GAH----LLQSLDGFVFVVSQEGRF 149

  Fly   279 TYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKV---------------- 327
            .|:||.|..|||:::::..|..:::|.|..||.|:.|.|.::..|..:.
Zfish   150 LYISETVSIYLGLSQVELTGSSVFDYIHPADHVEMAERLGIRPHLRAEAGCQTSHESASSSASTS 214

  Fly   328 ----KDEPQQNSGVS----THHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHL-----VVNA 379
                ..||..:|..|    ...|..|:|:|.|||.||  :::||:.|||||:||.:     :|.:
Zfish   215 SLAGTPEPAPHSPCSPVRELSERGFFIRMKSTLTKRG--LHVKSSGYKVIHVTGRIRCRPALVPS 277

  Fly   380 KGERL-----LMAIGRPIPHPSNI-EIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDT 438
            ....|     |:|:...:| ||.: |:.:.:..|:.:.::|::.||.::::.:.:..||.:::..
Zfish   278 SSRALHRPMGLVALAHTLP-PSTLNEVRMESHMFVFRVNMDLQVTYCENRISEYMDLSPAEVVGH 341

  Fly   439 SLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKP--QSVVCV 501
            :.:...|..|.:.:..:.:.:|.|||..|..||:|.:.|||.||.|.||:..:...|  ::|:.|
Zfish   342 TCYHFIHAEDLDTVRQSHEDLLRKGQVVTGYYRWLQRRGGYLWIQSCATVSINHKAPHERNVIWV 406

  Fly   502 NYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSEL 566
            |||:|..|.......|.|  .....:.:..||:.:.::...........|..|....|.:...|.
Zfish   407 NYVLSRPELADMPLDLLQ--LPESLRAERLQASSSPRDMSPKTQGSTGTQPLKSRSETDLKGKEA 469

  Fly   567 QAKPLQLESEKAEKTIEETKTIATIP---------------PVTATSTA--------DQIKQLPE 608
            .:.....:||...|.:.:|.:.:..|               |.|::..|        |:.:...:
Zfish   470 FSHNTSSQSENTRKRLHQTDSESGPPEARRRMEVFRQREDSPCTSSDQASDSEVEEDDERESEWD 534

  Fly   609 SNP-YKQILQAELLIKRENHSPGP------RTITAQL---LSGSSSGLRPE-EKRPKSVTASVLR 662
            .|| .|::...|...|:.|.:.|.      |.:...|   ::.|.|.::.| |....:|.|...|
Zfish   535 HNPSSKRVKNEEGASKQGNGANGAGKIHNGRAVIQHLKSVVTSSGSNIKTEQEVLGTTVGAGSGR 599

  Fly   663 -----------PSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSS 703
                       |:.:.|.:.||.:...:..|.|:..  ||:.|.:..|.:||
Zfish   600 RWSQPLLGNGGPNGSSPPSQPPNSTPTEAPPKGLFS--PPSPTLSPPIPASS 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	30/61 (49%)
		PAS	256..392	CDD:395786	51/169 (30%)
		PAS	265..>317	CDD:238075	21/51 (41%)
		PAS	404..505	CDD:238075	29/102 (28%)
npas1	NP_001315312.1	bHLH-PAS_NPAS1_PASD5	34..107	CDD:381574	31/69 (45%)
		PAS	130..188	CDD:214512	24/61 (39%)
		PAS_3	320..391	CDD:430001	21/70 (30%)