Protein Alignment sima and epas1b

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001034895.3
• Gene: epas1b / 555192
• ZFINID: ZDB-GENE-060607-11
• Length: 834
• Species: Danio rerio
• Alignment Length: 987
• Identity: 270/987 - (27%)
• Similarity: 426/987 - (43%)
• Gaps: 251/987 - (25%)

  Fly   155 NNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPS 219
            ::|:||||||||||||||||||:|.||:..|||.....:.|||||:||:.|:||:.|:::
Zfish    11 SSERRKEKSRDAARCRRSKETEVFYELAHHLPLPHSISSHLDKASIMRLAISFLRTRKLV----- 70

  Fly   220 LRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSEN 284
                |.......|..:..:.:        :.|        .|| ::.||:.|::.:||:.::|||
Zfish    71 ----NSGYNTPTEMTDADRLM--------DSW--------YLK-SLGGFITVVTSDGDMIFLSEN 114

  Fly   285 VVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLK 349
            :.:::|:|:::..|..|::::|.|||.||:|.||||..:.:|.|:       :|| .||.|:|:|
Zfish   115 INKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKAGIGKKGKE-------LST-ERDFFMRMK 171

  Fly   350 CTLTSRGRSINIKSASYKVIHITGHL-VVNAKGERLL-----------MAIGRPIPHPSNIEIPL 402
            ||:|:|||::|:||||:||:|.|||| |.|....|:|           :.:..||.|||||:.||
Zfish   172 CTVTNRGRTVNLKSASWKVLHCTGHLKVCNGCPARVLCGFKEPPLTCVVMMCEPIVHPSNIDTPL 236

  Fly   403 GTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGET 467
            .:.|||::||:||::||.|:::.:|:||:|:|||..|.:...|..|:|.:..:.:::.:|||..:
Zfish   237 DSKTFLSRHSMDMKYTYCDERVTELMGYNPEDLLGRSAYEFYHALDAENVTKSHQNLCTKGQAVS 301

  Fly   468 SRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQH 530
            .:||.|.|.|||.|:.::.|::|:  ..:||.:||||||:|::|.|..|:|:.|
Zfish   302 GQYRMLAKNGGYVWVETRGTVIYNSRNSQPQCIVCVNYVLSDVEEKSLIFSMDQ----------- 355

  Fly   531 HQAAETEKEPEKAADPEIIAQETKETVNTPIHTSE-LQAKPLQLESEKAEKTIEETKTIATIPPV 594
               .|:..:|.|              :|......| |.:.|..|...|.::..|:...:|..|..
Zfish   356 ---TESLFKPHK--------------LNGFFSPKEALGSDPADLLFTKLKEEPEDLTQLAPTPGD 403

  Fly   595 TATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTAS 659
            |..|......|..|...|.::......:....|. |.||        |.||    |....:.|.|
Zfish   404 TIISLDFGQSQYEEHTVYNKVSSVAPTVSHPVHD-GHRT--------SYSG----EMAKMAATFS 455

  Fly   660 VLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQD 724
            |  |..|||.:..|:...| .||...:....|.         .|:.::::.::
Zfish   456 V--PQSAPPSSATPSLSSC-STPSSPDDYYTPV---------DSDLKVELTEK------------ 496

  Fly   725 MSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDM-----------------L 772
                   ||:.|.:.....:.:..|||.       :.|:.:.|:..|                 .
Zfish   497 -------LFSLDTQEAKTSRNQETDLSD-------LDLETLAPYIPMDGEDFQLNPICPEEPPSE 547

  Fly   773 VGLMGT---CLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLS--PL- 831
            :|.:||   |.  .:|.||.....|.:|:  |||...||.....:....|..|:...|.|  |:
Zfish   548 IGTLGTNQQCF--SNITSLFQPLSSPSAA--HYQPKMSSGGDKQNINGGSVESWPPVPYSRGPMQ 608

  Fly   832 -----TPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTS 891
                 .|.||..:|....|..|               .|......:.:..:|||...|      |
Zfish   609 MPPYHDPASTPLSSMGGRQNLQ---------------WPPDPPLPSKAGMMDPLAAKR------S 652

  Fly   892 C--------SQHLHSPSIT-SKSPEDSSLPSLCSPNSLTQEDDFSFEAFAMRAPYIPIDDDMPLL 947
            |        :..:..|... .::..|:|...|...||..:    ||...||
Zfish   653 CQGMPANRMAPFMQRPMENFVQNYRDTSPARLALANSFKR----SFSQMAM-------------- 699

  Fly   948 TETDLMWCPPEDLQTMVPKEI-------------------DAIQQQLQQLQQQHHQ-QYAGNTGY 992
            .||     ||...|..|.|::                   |........:..||.: ||:||
Zfish   700 AET-----PPTKSQQTVWKKLRHESCAVMERKSLSSSALSDKSMAHNGAMDHQHRKSQYSGN--- 756

  Fly   993 QQQQQQPQLQQQHFSNSLCS------SPASTVSSLSPSPVQQHHQQQQAAVFTSDSSELAALLCG 1051
              |..||   .:|:....|:      .|:|.:..::...:....:.......|....|:...|
Zfish   757 --QNGQP---TKHYREQFCNYREFNMQPSSKMDGIASRLIGPSFETYSLPELTRYDCEVNVPL-- 814

  Fly  1052 SGNGTLSILAGS 1063
              .|.|.:|.||
Zfish   815 --QGNLHLLQGS 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	35/56 (63%)
		PAS	256..392	CDD:395786	56/147 (38%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	41/102 (40%)
epas1b	NP_001034895.3	None