DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and Ahrr

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	NP_001019456.1	Gene:	Ahrr / 498999	RGDID:	1559857	Length:	701	Species:	Rattus norvegicus

Alignment Length:	785	Identity:	168/785 - (21%)
Similarity:	267/785 - (34%)	Gaps:	252/785 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 EKRK-----EKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQF 216
            :||:     |||..:.|.|....||: ..|::.||...|.:::|||.||:|:::::|:::...|.
  Rat    20 QKRRLTMGTEKSNPSKRHRDRLNTEL-DHLASLLPFSPDIISKLDKLSVLRLSVSYLRVKSFFQA 83

  Fly   217 V--------PSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARE--LLKQTMDGFLLV 271
            :        |:|            :.||...             .|...:|  ||.::::||.||
  Rat    84 LQETCVWSAPAL------------SPEDHSS-------------RGFPVQEGRLLLESLNGFALV 123

  Fly   272 LSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSH-----------------------QCDHAEI 313
            :|.||.|.|.|..:|:|||..:.|.:.|.|::|.|                       |..||:.
  Rat   124 VSAEGMIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQSPHADT 188

  Fly   314 KEALSLKRELAQK-VKDEPQQNSGVSTHHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVV 377
            ...:..|...||: .|..|.:.|...|  |....|::|.|.|....:.::... |:..:.|....
  Rat   189 DNTVLGKLLRAQEGGKGLPSEYSAFLT--RCFICRVRCLLDSTSGFLTMQFQG-KLKFLFGQKKK 250

  Fly   378 NAKGERL-----LMAIGRPIPHPSNIEIPLGTSTFLTKHSLDMRFT----------YVDDKMHDL 427
            ...|..|     |..|..|: .||..|:.:.::....||..|:..|          ..:.::|..
  Rat   251 TPSGTALPPRLSLFCIVAPV-LPSVTEMKMKSAFLKAKHRADIVVTMDSRAKAVTSLCESELHPK 314

  Fly   428 LGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSR---YRFLGKYGGYCWILSQATIV 489
            |.|         |....:|          ::|:|..:|:|.|   .|.|.:  ..|..|....
  Rat   315 LNY---------LAGRSNG----------ENVISLFRGQTDRSHWTRALAR--SSCLCLRGGP-- 356

  Fly   490 YDKLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETK 554
             |.|.|:.      ...:.|...:.:.|.:...|..|:|.|..:...|
  Rat   357 -DLLDPKG------TSGDREEDDQKHILRRSPGARGQREMHKYSYGLE----------------- 397

  Fly   555 ETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESN--PYKQILQ 617
                ||:|...|.   ...|....|.|.:.|:..:...|.|..        :|..:  ||
  Rat   398 ----TPVHLRHLD---WSTEQRSQEGTTKLTRQPSKSEPSTCL--------VPHGSCVPY----- 442

  Fly   618 AELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVL-RPSP-------APPLTPPPT 674
                       ||.:   ....:.:.:..|.....|.....|.: ||.|       .|.....|.
  Rat   443 -----------PGSQ---GMFSASNMASFRESLDHPTGTYCSQMNRPLPDIHQGQVDPSTCHIPQ 493

  Fly   675 AVLCKKTPL-GVE--------------PNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQD 724
            ..|..:.|| |::              |:||      ..|.:..|..|.:....:::| :..:||
  Rat   494 GSLGSRIPLSGMQCFTARGFSTEDAKLPSLP------VNIGTPCNPVLSLEVPIKMEN-ESGSQD 551

  Fly   725 MSKGFCSLFADDGRG-LTM-----------LKEEPD--------DLSHHLASTNCIQLD------ 763
            :.:...:.....|.| :|.           ||.|||        ...|.:..||....|
  Rat   552 IVEASTTSCVWLGTGDMTRRHLVGFPARMHLKTEPDYRQQVCTPHRGHGILGTNPHSRDTVGSCR 616

  Fly   764 EMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPS----------------SSSTSA 812
            |..|    |.....|||.||..:.|  ..||.:.|    |.||                |.|.:|
  Rat   617 EHAP----LYSAHCTCLSPEPPHHL--FMCSHSES----QHPSLDQDCRAPIVKREPLDSPSWAA 671

  Fly   813 PSNTS 817
            |.:.:
  Rat   672 PGHVT 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	19/56 (34%)
		PAS	256..392	CDD:279347	43/166 (26%)
		PAS	265..>317	CDD:238075	22/74 (30%)
		PAS	404..505	CDD:238075	21/113 (19%)
		PAS_3	417..502	CDD:285623	18/97 (19%)
Ahrr	NP_001019456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		6/17 (35%)
		HLH	35..86	CDD:197674	16/51 (31%)
		PAS	108..174	CDD:214512	22/65 (34%)
		PAS	108..>173	CDD:279347	22/64 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..389		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..436		6/34 (18%)
		Needed for transcriptional repression. /evidence=ECO:0000250	555..701		31/132 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4449
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960