DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sima and hif1al2

DIOPT Version :9

Sequence 1:NP_001287599.1 Gene:sima / 43580 FlyBaseID:FBgn0266411 Length:1593 Species:Drosophila melanogaster
Sequence 2:NP_001012371.2 Gene:hif1al2 / 497283 ZFINID:ZDB-GENE-050211-2 Length:663 Species:Danio rerio


Alignment Length:859 Identity:190/859 - (22%)
Similarity:313/859 - (36%) Gaps:289/859 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 EKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLR 221
            |.||..||.||:.||.||:::|.||:|.|||......|.|||||:|:|||:|.:|.:|....|| 
Zfish    34 EWRKTCSRLAAQSRRKKESQLFKELTALLPLDLSMDGQRDKASVIRLTIAYLHLRGLLDTTDSL- 97

  Fly   222 DCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVV 286
                 :|:......|:                 :..||||...:.||:::||..|.:.:.::.:.
Zfish    98 -----MKRPSPGVSDK-----------------SHERELLDSALGGFVVLLSLNGKVIFATKGLT 140

  Fly   287 EYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLKCT 351
            .:.||.::|.:|:.:.|:.|.||..|:|:.|:  |.:..:   |||:        .::|:|:|  
Zfish   141 THTGINQMDLIGRSLLEFLHPCDQMEVKDILT--RLIGNQ---EPQK--------CEVFLRIK-- 190

  Fly   352 LTSRGRSINIKSASYKVIHITGHLVVNA-KGERLLMAIGR--PIPHPSNIEIPLGTSTFLTKHSL 413
                 :::|.|...:|:|..:|....:| .|...|:...|  ||...:.::..|...||::.||.
Zfish   191 -----KAMNTKLTGWKIIQCSGKKRSSATPGSSCLVLECRVLPIQEITEVDEALNACTFMSVHSP 250

  Fly   414 DMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGG 478
            ||.|||...::..|:|:...|||..|::...|.:|.:::......:|||||..|.:||.|.:|||
Zfish   251 DMTFTYCHSRVVKLIGFRDTDLLGQSVYQYYHPSDCQQIRKAHICLLSKGQVSTGKYRLLHRYGG 315

  Fly   479 YCWILSQATIVYDKLK--PQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPE 541
            |.|..:.|::|.:...  |:||||:||::|.:|                                
Zfish   316 YVWAETDASLVCNSQTGVPESVVCINYILSEVE-------------------------------- 348

  Fly   542 KAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQL 606
               .|.:                     |..||.                               
Zfish   349 ---QPNL---------------------PFLLEK------------------------------- 358

  Fly   607 PESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTP 671
                                        |.|||..:||...||.:           |:|.||   
Zfish   359 ----------------------------TEQLLKPTSSSYCPETE-----------PAPFPP--- 381

  Fly   672 PPTAVLCKKTPLGVEPNLPPTTTATAAI--ISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFA 734
                   .:...| |.:|..:....:.|  :...:..:|..:.|::.:..:...|.:...|.|  
Zfish   382 -------SRGQEG-EKDLKESNEHNSFITHLKQRDGDIQEVECTEIPHNTEGCYDFNCDQCEL-- 436

  Fly   735 DDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPF-----SDMLVGLMGTCLLPEDINSLDSTTCS 794
                                      .||.:.|:     .|.|:    |.::...::..:..||.
Zfish   437 --------------------------DLDSLAPYIPMHGEDFLL----TPIIDRAMDMPELNTCR 471

  Fly   795 TTASGQHYQSPSSSST------SAPSNTSSSNNSYANSPLSPLTPNSTATAS---------NPSH 844
            .:.|.......||..|      |..|...|.:||:....:|.....||...|         :..:
Zfish   472 PSCSSPSQNLDSSEGTTVLPVKSLNSTQQSVSNSFQTKRISDTNLISTKQWSDSFDLVNKVSKVY 536

  Fly   845 QQQQQHHNQQQQQQQQQQHH--------PQH---HDNSNSSSNIDPLFNYREESNDTSCSQHLHS 898
            ....:.||.|....:.:.:|        ||.   |.|.:.|:  .|..          |..||: 
Zfish   537 DYDPKQHNYQLFSSETKANHWVEEALKFPQPNRVHWNIDGST--PPWI----------CDGHLN- 588

  Fly   899 PSITSKSPEDSSLP--SLCSPNSLTQEDDFSFEAFAMRAPYI---------PIDDDMPLLTETDL 952
                ...|:..|||  :.|.|.....:.:....|..:..|.:         |::....||..|::
Zfish   589 ----HLEPKFRSLPEKTNCPPQKRRHQHEVKTAAALLTLPVLSGWECEVNAPLEHTSYLLQGTEI 649

  Fly   953 M-----------WC 955
            |           ||
Zfish   650 MAVLDQVASRVPWC 663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simaNP_001287599.1 HLH 156..209 CDD:238036 28/51 (55%)
PAS 256..392 CDD:279347 36/138 (26%)
PAS 265..>317 CDD:238075 15/51 (29%)
PAS 404..505 CDD:238075 40/102 (39%)
PAS_3 417..502 CDD:285623 32/86 (37%)
hif1al2NP_001012371.2 HLH 36..86 CDD:238036 27/49 (55%)
PAS 111..>184 CDD:279347 24/85 (28%)
PAS 119..225 CDD:238075 31/125 (25%)
PAS 243..340 CDD:238075 37/96 (39%)
PAS_3 254..341 CDD:285623 32/86 (37%)
HIF-1 429..461 CDD:288296 8/63 (13%)
HIF-1a_CTAD 620..656 CDD:285931 6/35 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170592832
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000232
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23043
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.940

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