Protein Alignment sima and hif1al2

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001012371.3
• Gene: hif1al2 / 497283
• ZFINID: ZDB-GENE-050211-2
• Length: 663
• Species: Danio rerio
• Alignment Length: 848
• Identity: 194/848 - (22%)
• Similarity: 319/848 - (37%)
• Gaps: 267/848 - (31%)

  Fly   157 EKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLR 221
            |.||..||.||:.||.||:::|.||:|.|||......|.|||||:|:|||:|.:|.:|....||
Zfish    34 EWRKTCSRLAAQSRRKKESQLFKELTALLPLDLSMDGQRDKASVIRLTIAYLHLRGLLDTTDSL- 97

  Fly   222 DCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVV 286
                 :|:......|:                 :..||||...:.||:::||..|.:.:.::.:.
Zfish    98 -----MKRPSPGVSDK-----------------SHERELLDSALGGFVVLLSLNGKVIFATKGLT 140

  Fly   287 EYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLKCT 351
            .:.||.::|.:|:.:.|:.|.||..|:|:.|:  |.:..:   |||:        .::|:|:|
Zfish   141 THTGINQMDLIGRSLLEFLHPCDQMEVKDILT--RLIGNQ---EPQK--------CEVFLRIK-- 190

  Fly   352 LTSRGRSINIKSASYKVIHITGHLVVNA-KGERLLMAIGR--PIPHPSNIEIPLGTSTFLTKHSL 413
                 :::|.|...:|:|..:|....:| .|...|:...|  ||...:.::..|...||::.||.
Zfish   191 -----KAMNTKLTGWKIIQCSGKKRSSATPGSSCLVLECRVLPIQEITEVDEALNACTFMSVHSP 250

  Fly   414 DMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGG 478
            ||.|||...::..|:|:...|||..|::...|.:|.:::......:|||||..|.:||.|.:|||
Zfish   251 DMTFTYCHSRVVKLIGFRDTDLLGQSVYQYYHPSDCQQIRKAHICLLSKGQVSTGKYRLLHRYGG 315

  Fly   479 YCWILSQATIVYDKLK--PQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPE 541
            |.|..:.|::|.:...  |:||||:||::|.:|
Zfish   316 YVWAETDASLVCNSQTGVPESVVCINYILSEVE-------------------------------- 348

  Fly   542 KAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQL 606
               .|.:                     |..||.
Zfish   349 ---QPNL---------------------PFLLEK------------------------------- 358

  Fly   607 PESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTP 671
                                        |.|||..:||...||.:           |:|.||
Zfish   359 ----------------------------TEQLLKPTSSSYCPETE-----------PAPFPP--- 381

  Fly   672 PPTAVLCKKTPLGVEPNLPPTTTATAAI--ISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFA 734
                   .:...| |.:|..:....::|  :...:..:|..:.|::.:..:...|.:...|.|..
Zfish   382 -------SRGQEG-EKDLKESNEHNSSITHLKQRDGDIQEVECTEIPHNTEGCYDFNCDQCELDL 438

  Fly   735 DD------GRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTC 793
            |.      ..|...|.....|.:..:...|..:....:| |..|....||.:||  :.||:||..
Zfish   439 DSLAPYIPMHGEDFLLTPIIDRAMDMPELNTCRPSFSSP-SQNLDSSEGTTVLP--VKSLNSTQQ 500

  Fly   794 STTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQQQQHHNQQQQQQ 858
            |.:.|   :|:...|.|:..| |...::|:.       ..|..:...:..|:|    ||.|....
Zfish   501 SVSNS---FQTKRISDTNLIS-TKQWSDSFD-------LVNKVSKVYDYDHKQ----HNYQLFSS 550

  Fly   859 QQQQHH--------PQHH------DNSNSSSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDS 909
            :.:.:|        ||.:      |.|......|...|:.|                    |:..
Zfish   551 ETKANHWVEEALKFPQPNRVHWNIDGSTPPWICDGRLNHLE--------------------PKFR 595

  Fly   910 SLP--SLCSPNSLTQEDDFSFEAFAMRAPYI---------PIDDDMPLLTETDLM---------- 953
            |||  :.|.|.....:.:....|..:..|.:         |::....||..|::|
Zfish   596 SLPEKTNCPPQKRRHQHEVETAAALLTLPVLSGWECEVNAPLEHTSYLLQGTEIMAVLDQVASRV 660

  Fly   954 -WC 955
             ||
Zfish   661 PWC 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	30/56 (54%)
		PAS	256..392	CDD:395786	36/138 (26%)
		PAS	265..>317	CDD:238075	15/51 (29%)
		PAS	404..505	CDD:238075	40/102 (39%)
hif1al2	NP_001012371.3	None