Protein Alignment sima and arnt

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001428910.1
• Gene: arnt / 493634
• ZFINID: ZDB-GENE-060126-7
• Length: 747
• Species: Danio rerio
• Alignment Length: 819
• Identity: 169/819 - (20%)
• Similarity: 296/819 - (36%)
• Gaps: 226/819 - (27%)

  Fly   155 NNEKR--KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFV 217
            |:::|  :|...:..|.||:|.|....|||..:|..:....:.||.:::|:.::.:|
Zfish    58 NDKERFARENHSEIERRRRNKMTAYITELSDMVPACSALARKPDKLTILRMAVSHMK-------- 114

  Fly   218 PSLRDCNDDIKQDIETAEDQQEVKPKLEVGT--EDWLNGAEARELLKQTMDGFLLVLSHE-GDIT 279
             |||...:       |:.|          ||  ..:|...|.:.|:.:..||||.|:|.| |.:.
Zfish   115 -SLRGTGN-------TSTD----------GTYKPSFLTDQELKHLILEAADGFLFVVSCETGRVV 161

  Fly   280 YVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLK-------RELAQKV----KDEPQQ 333
            |||::|...|...:.|.||..:::..|..|..:::|.||..       |.|..|.    |:..|.
Zfish   162 YVSDSVTPVLNQAQSDWLGSSLYDQLHPDDVEKLREQLSTTENNNNSGRMLDMKTGTVKKEGGQA 226

  Fly   334 NSGVSTHHRDLFV-RLKC--------------TLTSRGRSINIKSA-----SYKVIHITGHL--- 375
            ...:|...|..|: |::|              .|.:|.|: .:.||     .|.|:|.||::
Zfish   227 TVRMSMGARRSFICRMRCGVCPVEPVSLNRLNFLRTRNRN-GLGSAKDGEQQYVVVHCTGYIRSW 290

  Fly   376 -----------VVNAKGERL-LMAIGR------PIPHP-SNIEIPLGTSTFLTKHSLDMRFTYVD 421
                       ..|.:|.|. |:||||      |.... :||.:|:   .|:::|:....:|:||
Zfish   291 PPAGMNLSEEEADNNQGNRFCLVAIGRLQVTCCPSDTSINNISVPV---EFISRHNSQGVYTFVD 352

  Fly   422 DKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLS-KGQGETSRYRFLGKYGGYCWILSQ 485
            .:....:|:..::||..::....|..|...|..:.:.|:. :||..:..:||..|...:.|:.:.
Zfish   353 HRCTATVGFQTQELLGKNILDFAHPEDQGLLRDSLQQVVKLRGQVMSVMFRFQSKSREWVWMRTS 417

  Fly   486 ATIVYDKLKP--QSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEI 548
            :....:....  :.::|.|..::...::..:..|:                    .|.....|
Zfish   418 SFTFQNPFSEEIEYIICTNTNVNRGSSEGSVSPLS--------------------SPSLGQSP-- 460

  Fly   549 IAQETKETVNTP----IHTSELQAKPLQLE-SEKAEKTIEETKTIATIPPVTATSTADQIKQLPE 608
                  ...:||    :...:||.:.::|: ...:::|..|...:| :|.|:..:..
Zfish   461 ------NCPSTPSPGCVTVRQLQQQQVELDGGGMSQETPYENSQVA-LPQVSVQTCG-------- 510

  Fly   609 SNPYKQILQAELLIKRENHSPGPRTITAQLLSGSS----SGLRPEEKRPKSVTASVLRPSPAPPL 669
                  ::.|:       ||  .:.:::.:.||..    :...|...||.....|.:.|....|:
Zfish   511 ------VVSAD-------HS--SKAVSSSVSSGQQVYPPAAAFPSPARPTETFRSPVLPQQMVPV 560

  Fly   670 TPPPTAVLC----KKTPLGVEPN------LPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQD 724
            ......:|.    :.||.||..:      .|...||...:.:::.|.....|........|.|..
Zfish   561 AHSAGQMLAQMSRQSTPSGVSGSNNSPIQAPSGPTAPPGLWNTTRQPFSTQQVAGPIGKNQSAPF 625

  Fly   725 MSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLD 789
            ...||.|..|                                |.:....|.||..
Zfish   626 NMGGFSSASA--------------------------------PSTSSSFGQMGGA---------- 648

  Fly   790 STTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLT-----PNSTATASNPSHQQQQQ 849
            |.:.::|:|.|...|.|:.||:...:......::...|...:|     |:.|.|          |
Zfish   649 SASMASTSSYQQINSHSNPSTNGYGDVGQIAAAFGTRPAEGVTGWQQWPSQTHT----------Q 703

  Fly   850 HHNQQQQQQQQQQHHP---QHHDNSNSSSNID----PLF 881
            .....|.|..|....|   ...|.|.|.||.|    |:|
Zfish   704 ASADTQVQNNQTDMFPDVLSMLDQSGSFSNGDFSEMPMF 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	15/58 (26%)
		PAS	256..392	CDD:395786	51/188 (27%)
		PAS	265..>317	CDD:238075	19/52 (37%)
		PAS	404..505	CDD:238075	20/103 (19%)
arnt	NP_001428910.1	None