DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and epas1

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	NP_001005647.1	Gene:	epas1 / 448117	XenbaseID:	XB-GENE-981612	Length:	862	Species:	Xenopus tropicalis

Alignment Length:	972	Identity:	268/972 - (27%)
Similarity:	421/972 - (43%)	Gaps:	280/972 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 NNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPS 219
            ::|:||||||||||||||||||:|.||:..|||.....:.|||||:||:||:||:..::|..|
Frog    11 SSERRKEKSRDAARCRRSKETEVFYELAHQLPLPQSISSHLDKASIMRLTISFLRTHKLLSSV-- 73

  Fly   220 LRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSEN 284
               |.|   ::||||.::|                  ...|..:.::||:.|::.:||:.::|||
Frog    74 ---CAD---RNIETASEKQ------------------LDNLYLKALEGFVAVVTQDGDMIFLSEN 114

  Fly   285 VVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLK 349
            |.:|||:|:::..|..|::::|.|||.||||.||:|..:....|     |...:|.| |.|:|:|
Frog   115 VNKYLGLTQVELTGHSIFDFTHPCDHDEIKENLSMKTGVGSGKK-----NKDANTEH-DFFMRMK 173

  Fly   350 CTLTSRGRSINIKSASYKVIHITGHLVVNAKGE--------------RLLMAIGRPIPHPSNIEI 400
            ||:|:|||::|:|||::||:|.|||  |.|...              ..|:.:.:||.|||||:|
Frog   174 CTVTNRGRTVNLKSATWKVLHCTGH--VKAYNSYYPHSLCGYKEPVLSCLIMMCQPIQHPSNIDI 236

  Fly   401 PLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQG 465
            ||.:.|||::||:||:|||.||::.:|:||.|::||..|.:...|..|||.:..:.:::.:|||.
Frog   237 PLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSESMTKSHQNLCAKGQV 301

  Fly   466 ETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKE 528
            .|.:||.|.|:|||.|:.:|:|::|:  ..:||.:||||||:|.:|....::|:.|
Frog   302 VTGQYRMLAKHGGYLWVETQSTVIYNTRNSQPQCIVCVNYVLSEIEKNDVVFSMDQ--------- 357

  Fly   529 QHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAE----KTIEETKTIA 589
                       .|....|.::      |:|: |.:|.:|        ||::    |..:|.:.:|
Frog   358 -----------TESLFKPHLM------TMNS-IFSSSVQ--------EKSDFLFTKLKKEPEDLA 396

  Fly   590 TIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPK 654
            .:.|                                  :||...::...  ||.:  ..|:....
Frog   397 QLAP----------------------------------TPGDEIVSLDF--GSQT--FDEQSNFN 423

  Fly   655 SVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEP--------NLPPTTTATAAIISSSNQQLQIAQ 711
            ||..|   ||              |:.||.|:.        |||   :..|..:|:.|.....:.
Frog   424 SVQTS---PS--------------KQWPLEVKNLNSQVDIINLP---SFKAPQVSTGNSTPSASS 468

  Fly   712 QTQLQNPQQPA-------QDMSKGFC-SLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPF 768
            .:....|..|.       :|:..... .|||.|...........:|.       |.:.|:.:.|:
Frog   469 NSTCSTPSSPEAYYSSLDEDLKIELIEKLFAMDTEAKNQCNTTQNDF-------NDLDLETLAPY 526

  Fly   769 SDMLVGLMGTCLLPED-----INSL---DSTTCSTTASGQHYQSPSSS----STSAPSN------ 815
                        :|.|     :|.:   :||...|....|...|..||    ||.:|.|
Frog   527 ------------IPMDGEDFQLNPICQEESTISDTPQKAQQNLSSISSLFQPSTPSPQNQFLQQN 579

  Fly   816 ----TSSSNNSYANSPLS-----------PLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHP 865
                |::.:|:.:..||.           ||||..  |.::|.........|.|........:.|
Frog   580 ICQTTAAKSNNGSQDPLPSVLFNNEKKALPLTPYH--TGASPPLSSMGGRPNVQWPPDPPVSYMP 642

  Fly   866 ------QHHDNSNSSSNIDP---LFN---YREESNDTSCSQHLHSPSITSKSPEDSSLPSLCSPN 918
                  :.::.|.||....|   |.|   |::.|        |.|.....|....:.:| .|:..
Frog   643 NKWRFVEQYNGSLSSLPSGPPVHLHNMPLYKQRS--------LESFGQRGKDLHPAEIP-FCNSM 698

  Fly   919 SLTQEDDFSFEAFAMRAPYIPIDD-----DMPLLTETDLMW----------CP----PEDLQTMV 964
            ...::.|:..:.|    |.:.:.|     :.||     :||          ||    .:.|.|.|
Frog   699 KRKRQLDYGEQGF----PQLDVGDLQGESNNPL-----IMWKRMKALKSGSCPLVAERKSLSTSV 754

  Fly   965 PKE--IDAIQQQLQQ-LQQQHHQQYA-----------GNTGYQQQQQQPQLQQQHFSNSLCS 1012
            ..:  :....::|.| :.||..||..           .||.:........:||......|.|
Frog   755 LNDGYVCTRHRELNQPISQQQQQQCVAPPRDGRKTAYSNTFFSCSYHDYNMQQTEKMKGLTS 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	35/52 (67%)
		PAS	256..392	CDD:279347	54/149 (36%)
		PAS	265..>317	CDD:238075	23/51 (45%)
		PAS	404..505	CDD:238075	45/102 (44%)
		PAS_3	417..502	CDD:285623	35/86 (41%)
epas1	NP_001005647.1	HLH	12..68	CDD:238036	36/55 (65%)
		PAS	92..147	CDD:214512	23/54 (43%)
		PAS	240..339	CDD:238075	41/98 (42%)
		PAS_3	253..340	CDD:285623	35/86 (41%)
		HIF-1	511..543	CDD:288296	7/50 (14%)
		HIF-1a_CTAD	825..861	CDD:285931
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9575
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2352
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm49414
Panther	1	1.100	-	-	O	PTHR23043
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1038
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.150