Protein Alignment sima and tgo

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_731308.1
• Gene: tgo / 41084
• FlyBaseID: FBgn0264075
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 734
• Identity: 177/734 - (24%)
• Similarity: 279/734 - (38%)
• Gaps: 225/734 - (30%)

  Fly   154 MNNEKRKEKSRDAAR---C-----RRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKI 210
            |:....::|.|.|:|   |     ||:|.|....|||..:|..:....:.||.:::|:.:|.:|
  Fly     1 MDEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMK- 64

  Fly   211 REMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGT--EDWLNGAEARELLKQTMDGFLLVLS 273
                    :||...:       |:.|          ||  ..:|...|.:.|:.:..||||.|:|
  Fly    65 --------ALRGTGN-------TSSD----------GTYKPSFLTDQELKHLILEAADGFLFVVS 104

  Fly   274 -HEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLK------RELAQK---VK 328
             ..|.:.|||::|...|..|:.|..|..::|:.|..|..:|:|.||.:      |.|..|   ||
  Fly   105 CDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVK 169

  Fly   329 DEPQQNS-GVSTHHRDLFVRLKCTLTSRGRSINIKS---------------------ASYKVIHI 371
            .|..|:| .:|...|..|:   |.:  |..::|.:|                     .:|.|:|.
  Fly   170 KEGHQSSMRLSMGARRGFI---CRM--RVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHC 229

  Fly   372 TGH--------LVVNAKGER---------LLMAIGRPIPHPSNIEIPLGTST------------- 406
            ||:        :..|...||         .|:||||       :::   |||
  Fly   230 TGYIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGR-------LQV---TSTAANDMSGSNNQSE 284

  Fly   407 FLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVL-SKGQGETSRY 470
            |:|:|::|.:||:||.::.::|||:|.:||....:...|..|...:..:|..|| .|||..:..|
  Fly   285 FITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLY 349

  Fly   471 RFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAE 535
            |...|...|.|:.:||   |..|.|.:.. |.|::....:...::......||:...||..|..:
  Fly   350 RARAKNSEYVWLRTQA---YAFLNPYTDE-VEYIVCTNSSGKTMHGAPLDAAAAHTPEQVQQQQQ 410

  Fly   536 TEKEPEKAADPEI---------IAQETKE----------TVNTPIHTSELQAKPLQLESEKAEKT 581
            .|:.....|.|.:         :...|.:          ...||....:.|.:|...::.....|
  Fly   411 QEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYT 475

  Fly   582 IEETKT---------IATIP-------PVTATSTA------DQIKQLP--ESNPYKQILQAELLI 622
            .:.|.:         :|.||       ||...|.|      .|.:|.|  |...|:|...|
  Fly   476 YDTTHSPYSAGGPSPLAKIPKSGTSPTPVAPNSWAALRPQQQQQQQQPVTEGYQYQQTSPA---- 536

  Fly   623 KRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAV-LCKKTPLGVE 686
                .||...|.| ||.:|:.:   .::.:|.:..|       .||  |||.|. :......|..
  Fly   537 ----RSPSGPTYT-QLSAGNGN---RQQAQPGAYQA-------GPP--PPPNAPGMWDWQQAGGH 584

  Fly   687 PNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQP----------AQDMSKGFCSLFADDGRGLT 741
            |: ||..||                     :|..|          .|...:.|..:       |.
  Fly   585 PH-PPHPTA---------------------HPHHPHAHPGGPAGAGQPQGQEFSDM-------LQ 620

  Fly   742 MLKEEP---DDLSHHLAST 757
            ||...|   :||:.::.||
  Fly   621 MLDHTPTTFEDLNINMFST 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	18/64 (28%)
		PAS	256..392	CDD:395786	52/184 (28%)
		PAS	265..>317	CDD:238075	20/52 (38%)
		PAS	404..505	CDD:238075	37/114 (32%)
tgo	NP_731308.1	bHLH-PAS_ARNT	9..74	CDD:381517	21/80 (26%)
		PAS	90..154	CDD:214512	23/63 (37%)
		PAS_11	282..384	CDD:464214	34/105 (32%)