DRSC/TRiP Functional Genomics Resources

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Protein Alignment sima and hif1ab

DIOPT Version :9

Sequence 1:NP_001287599.1 Gene:sima / 43580 FlyBaseID:FBgn0266411 Length:1593 Species:Drosophila melanogaster
Sequence 2:NP_001296971.1 Gene:hif1ab / 393202 ZFINID:ZDB-GENE-040426-706 Length:777 Species:Danio rerio


Alignment Length:754 Identity:247/754 - (32%)
Similarity:377/754 - (50%) Gaps:156/754 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 MNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVP 218
            :::|:||||||||||.||.||:|:|.||:..|||..:..:.|||||:||:||::|::|::|    
Zfish    12 VSSERRKEKSRDAARSRRGKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLL---- 72

  Fly   219 SLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSE 283
                 |.|.|::.|..|            .|..|||     ...:.::|||:|||.:||:.|:||
Zfish    73 -----NSDEKEEKEENE------------LESQLNG-----FYLKALEGFLMVLSEDGDMVYLSE 115

  Fly   284 NVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRL 348
            ||.:.:|:|:.|..|..|:|:||.|||.|::|.| :.|..::|.|   :||:     .|..|:|:
Zfish   116 NVSKSMGLTQFDLTGHSIFEFSHPCDHEELREML-VHRTGSKKTK---EQNT-----ERSFFLRM 171

  Fly   349 KCTLTSRGRSINIKSASYKVIHITGHLVVNAKGE------------RLLMAIGRPIPHPSNIEIP 401
            |||||||||::|||||::||:|..||:.|:...|            ..|:.|..|||||||||:|
Zfish   172 KCTLTSRGRTVNIKSATWKVLHCAGHVRVHEGSEASEDSGFKEPPVTYLVLICEPIPHPSNIEVP 236

  Fly   402 LGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGE 466
            |.:.|||::|:|||:|:|.|:::.:|:||.|.|||:.|::...|..||:.|..|..::.:|||..
Zfish   237 LDSKTFLSRHTLDMKFSYCDERITELMGYEPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQAT 301

  Fly   467 TSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQ 529
            |.:||.|.|.||:.|:.:|||::|:  ..:||.:||||||:|.:.....:.|| ||| .:|.|..
Zfish   302 TGQYRMLAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSL-QQT-VTEPKAV 364

  Fly   530 HHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPV 594
            ..::.|||   ||.::.:|:.....|::|..:.:|.|.           .|..||.:.:..:.| 
Zfish   365 EKESEETE---EKTSELDILKLFKPESLNCSLESSTLY-----------NKLKEEPEALTVLAP- 414

  Fly   595 TATSTADQIKQLPESNPYKQI-LQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTA 658
               :..|.|..|..:|....| |..|:.:..:...|            |||     ||.|.|:: 
Zfish   415 ---AAGDAIISLDFNNSDSDIQLLKEVPLYNDVMLP------------SSS-----EKLPLSLS- 458

  Fly   659 SVLRPSPAPPLTPPPTAVLCKKTPLGVE--------PNLP-PTTTATAAIISSSNQQLQIAQQTQ 714
                     ||||..:.....|...|.|        ..:| ||.|.:.:.:.||           
Zfish   459 ---------PLTPSDSIPALTKLETGGEDFPFSSASDRVPDPTNTPSTSGLGSS----------- 503

  Fly   715 LQNPQQPAQ-------DMSKGFC-----SLFADDGRGLTMLKEEP-DDLSHHLASTNCIQLDEMT 766
              .|..|..       |:|..|.     .|||.|....|....:| :||          .|:.:.
Zfish   504 --GPNSPMDYGFPVEPDISSEFKLDLVEKLFAIDTEAKTPFSTQPMEDL----------DLEMLA 556

  Fly   767 PFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQ----SPSSSSTSAPSNTSSSNNSYANSP 827
            |:..|.....  ..:|..::.|.|.|.|.:|....:|    ||:|.::|..|......:|.|.||
Zfish   557 PYIPMDDDFQ--LRIPSPLDPLPSATHSVSAMSSLFQPLPSSPASPASSTSSTVKQEASSRAPSP 619

  Fly   828 L--------SPLTPNSTATASNPSHQQQQQHHNQQQQQQ 858
            |        :|::|.|.:..::|......|..:|...::
Zfish   620 LHLLQEVCSAPVSPFSGSRDASPVRSSTPQSSSQLNNRE 658

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simaNP_001287599.1 HLH 156..209 CDD:238036 31/52 (60%)
PAS 256..392 CDD:279347 58/147 (39%)
PAS 265..>317 CDD:238075 26/51 (51%)
PAS 404..505 CDD:238075 45/102 (44%)
PAS_3 417..502 CDD:285623 35/86 (41%)
hif1abNP_001296971.1 HLH 14..74 CDD:238036 34/68 (50%)
PAS 94..149 CDD:214512 26/54 (48%)
PAS 239..338 CDD:238075 41/98 (42%)
PAS_3 254..339 CDD:285623 34/84 (40%)
HIF-1 543..574 CDD:288296 7/42 (17%)
HIF-1a_CTAD 740..776 CDD:285931
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170592834
Domainoid 1 1.000 82 1.000 Domainoid score I8333
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000232
OrthoInspector 1 1.000 - - otm24521
orthoMCL 1 0.900 - - OOG6_106128
Panther 1 1.100 - - LDO PTHR23043
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4976
SonicParanoid 1 1.000 - - X1038
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
98.870

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