DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and trh

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	NP_001261207.1	Gene:	trh / 38065	FlyBaseID:	FBgn0262139	Length:	1022	Species:	Drosophila melanogaster

Alignment Length:	1070	Identity:	255/1070 - (23%)
Similarity:	387/1070 - (36%)	Gaps:	360/1070 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 PAPG---------------SQPFVGAMLGPNMSSTGMQRYHPY--HQQQPQDAFYRQRGSLLNVA 117
            |.||               :.||..:.:.|......|..|:..  |||.|....:.|:
  Fly    19 PTPGHPGSHMATMGSLGMPAVPFTHSWMVPTQDLCAMPPYNKMTGHQQPPGAGMHAQQ------- 76

  Fly   118 TPCRESRPWSYAYCYGYAPTNTQPCQFSQFVDIEDFMNNEKRKEKSRDAARCRRSKETEIFMELS 182
                                  ||.:....         |.||||||||||.||.||...|.||:
  Fly    77 ----------------------QPLEPGIL---------ELRKEKSRDAARSRRGKENYEFYELA 110

  Fly   183 AALPLKTDDVNQLDKASVMRITIAFLKIREMLQF--VPSLRDCNDDIKQDIETAEDQQEVKPKLE 245
            ..|||.....:||||||::|:||::||:|:....  .|..|:.:...|  :::|..::  .|.::
  Fly   111 KMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPPWTREASSSSK--LKSAAIRR--SPAVD 171

  Fly   246 V-----GTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYS 305
            :     ||.           :.|::|||.|.::.:|...|:||.|..|||:::::..|..|::|.
  Fly   172 LFEQHQGTH-----------ILQSLDGFALAVAADGRFLYISETVSIYLGLSQVEMTGSSIFDYI 225

  Fly   306 HQCDHAEIKEALSLKRE----------------------LAQKVKDEPQQNSG------------ 336
            ||.||:||.:.|.|...                      :|..........||
  Fly   226 HQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGTHGTNNPDVAAS 290

  Fly   337 ---VST-----HHRDLFVRLKCTLTSRGRSINIKSASYKVIHIT------GHLVVNAKGER---- 383
               .||     :.|...||:|.|||.||  .:.||:.|:....|      .:...|||..:
  Fly   291 MTQASTSGYKGYDRSFCVRMKSTLTKRG--CHFKSSGYRASDATSNCNNGNNASNNAKNVKNPGS 353

  Fly   384 -----LLMAIGRP-----------------------IPHPSNIEIPLGTSTFLTKHSLDMRFTYV 420
                 ||:...||                       :|.||..||.|....|:|:.:.|:|..:.
  Fly   354 NYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLECDMFVTRVNFDLRVAHC 418

  Fly   421 DDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQ 485
            :.::.|||.|||:||::.||:|..|..|:.||..:...::.|||..|..||.:.|.|||.|:.:.
  Fly   419 EPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTGYYRLMNKSGGYTWLQTC 483

  Fly   486 ATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEK---EPEKAAD 545
            ||:|..  ....|:::||||||||.||::.|.... |...|....:|.:....:|   .|...|.
  Fly   484 ATVVCSTKNADEQNIICVNYVISNRENENMILDCC-QLEPSPDSIKHEEGLGNDKSSGSPGGDAS 547

  Fly   546 PE----IIAQETKETVNTP------------------IHTSELQA--------KPLQLESEKAE- 579
            .|    :.|.:.|  :|:|                  .|.|.:.:        .||.:|.:...
  Fly   548 GEGNSHLSAGDMK--LNSPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKDSPTPLGVEIDSGVL 610

  Fly   580 KTIEETKTIATIPPVTATSTADQIK--QLPESNPYKQILQAELLIK---RENHSPGPRT-----I 634
            .|...|...|..|||.:|....:.|  |..|....:|::..:.|.|   .|.....||:     :
  Fly   611 PTTVATPVPAATPPVQSTKRKRKTKASQHAEDQGQEQVISEQPLPKLPTMEQRDQQPRSRLPSIV 675

  Fly   635 TAQLLSGSSSGLRPEEK-------RPKSVTA-----------SVLR------------------- 662
            ..|..|.:.|.::..|:       .|.:|.:           |:|:
  Fly   676 DEQPSSAADSAVKDLEQAMSKHLPSPAAVVSVAPPNTDFSADSLLKQQQQQQQLDPNEKSSTIQW 740

  Fly   663 ---PSPAPPLTPPPTAVL--------------CKKTPLGVEPNL-------PPTTTATAAIISSS 703
               |...||...|.||:|              .::||.||.|.:       .|..|...:..|..
  Fly   741 IGTPYQQPPAPMPATALLRQLYANRESVIRATARQTPTGVGPGVFYGDQQTGPLPTPPGSESSYE 805

  Fly   704 NQQLQIAQQTQLQNP--QQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMT 766
            ||.||:.......:|  |:.:.|   .|.:|.:..|       .....:.:|.|         ||
  Fly   806 NQYLQLHSAASGGHPGGQKTSAD---AFTNLVSTYG-------GYHSSIDYHNA---------MT 851

  Fly   767 PFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSP-------------------------S 806
            |.|.         :.|.|.|..........::|.:..:|                         |
  Fly   852 PPSS---------VSPRDSNQPGKAAPVLASNGGYDYAPDPLRGQYATSSGDVVPATLPLKPQAS 907

  Fly   807 SSSTSAPSNTSSSNN--SYAN-------------------SPLSP--LTPNSTATASN---PSHQ 845
            .::|..||.::::..  :|:|                   ||.|.  .||:.......   ||.|
  Fly   908 YTATMHPSGSTTTEGGVTYSNLDQPQYFAPHSSFHLYHKGSPASGWYSTPSXVVDDQGQVPPSCQ 972

  Fly   846 QQQQHHNQQQQQQQQQQHHPQHHDNSNSSS 875
            .|..||:          ||..|.|.|..||
  Fly   973 DQYHHHH----------HHHHHQDGSAGSS 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	30/52 (58%)
		PAS	256..392	CDD:279347	49/215 (23%)
		PAS	265..>317	CDD:238075	21/51 (41%)
		PAS	404..505	CDD:238075	38/102 (37%)
		PAS_3	417..502	CDD:285623	31/86 (36%)
trh	NP_001261207.1	HLH	85..137	CDD:238036	30/51 (59%)
		PAS	176..236	CDD:214512	24/70 (34%)
		PAS	180..>236	CDD:279347	22/66 (33%)
		PAS	403..505	CDD:238075	38/101 (38%)
		PAS_3	415..502	CDD:285623	31/86 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466435
Domainoid	1	1.000	51	1.000	Domainoid score	I7753
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm14250
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.950