Protein Alignment sima and npas2

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_840084.1
• Gene: npas2 / 352934
• ZFINID: ZDB-GENE-030408-3
• Length: 845
• Species: Danio rerio
• Alignment Length: 944
• Identity: 200/944 - (21%)
• Similarity: 360/944 - (38%)
• Gaps: 210/944 - (22%)

  Fly   133 GYAPTNTQPCQFSQFVDIEDFMNNEKRKEKSRDAAR-----CRRSKETEIFMELSAAL-----PL 187
            |..|::.:....|..||  |.| :|..|::::.|:|     .||.:...:..||...|     |.
Zfish    15 GLCPSSRREWDTSSCVD--DLM-DEDEKDRAKRASRNKSEKKRRDQFNVLIKELCTMLQGQGHPR 76

  Fly   188 KTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWL 252
            |      :||:::::.||.||:.::             :|....|:.|.:|:.||       .:|
Zfish    77 K------MDKSTILQRTIDFLQKQK-------------EITAQTESCEVRQDWKP-------SFL 115

  Fly   253 NGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEAL 317
            :..|..:|:.:.:||||:.|:.:|:|.|||::|...:|....|.:.|.|..:..:.:||::.:.|
Zfish   116 SNEEFTQLMLEALDGFLIALTTDGNIIYVSDSVSSLIGHLPSDMVDQNILNFLPEREHADVYKLL 180

  Fly   318 SLKRELAQ-KVKDEPQQNSGVSTHHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAKG 381
            |....|.: ...|....|   .||     |...|.: :||.....:..:|:.:...|....: ..
Zfish   181 SSHMLLTESSTVDLLNSN---ETH-----VEFCCHI-ARGNIDPKEPPTYEYVKFVGDFKFH-NN 235

  Fly   382 ERLLMAIGRPIPHP----SNIE--------IPLGTSTFL--------------TKHSLDMRFTYV 420
            ..|....|..:..|    |:||        :.|.|..||              ::|||:.:|.::
Zfish   236 VPLSSCNGYDLAFPRTLQSSIEEQVCLVATVRLATPQFLKDLCNVEDVCDEFTSRHSLEWKFLFL 300

  Fly   421 DDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQ 485
            |.:...::||.|.::|.||.:...|..|.|.:....|.::..|:|::..||||.|...:.|:.:.
Zfish   301 DHRASPIIGYLPFEVLGTSGYDYYHVDDLELIAQCHKQLMQCGKGKSCYYRFLTKGQQWIWLQTH 365

  Fly   486 ATIVYDK--LKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEI 548
            ..|.|.:  .||:.:||.:.|:|..|.:.|     ::.....::.....|..:.|..|...|...
Zfish   366 YYITYHQWNSKPEFIVCTHSVVSYAEVRAE-----RRREFGLEESSSDMATSSIKGQEVFLDMCP 425

  Fly   549 IAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQL-PESNPY 612
            ..:.|::.:|:....|.      |...:.:...:.::.:.:::....|.:::.|...: ||.:.
Zfish   426 PLEATRDRINSARSVSS------QSSRKSSHTALSDSASNSSVRYTEACTSSRQSASIGPEKSS- 483

  Fly   613 KQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVL 677
                      .|..|: |.:|:..:..|.....|.|...:..::|.|:.      ....|...|:
Zfish   484 ----------NRMTHT-GTKTLIQRQSSSEPPSLSPSCSQHSAMTQSLY------SFQQPQLGVM 531

  Fly   678 CKKTPLGVEPNLPPTTTATAAIISSSNQQL-QIAQQTQLQN----PQQPAQDMSKGFCSLFADDG 737
            .:     ::..|...|....|.|.:..|:| .|.::.||.|    .|||.|....|........|
Zfish   532 HQ-----LKEQLEERTRILQADIKTQQQELHDIKEKLQLANLQMLLQQPIQGEFAGSGPQQQGPG 591

  Fly   738 RGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHY 802
            |        |...:.|....:|:                                    :...|.
Zfish   592 R--------PAQQNTHPKPQHCV------------------------------------SHSSHT 612

  Fly   803 QSPSSSSTSAPSNTSSSNNSYANS-PLSPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQ 866
            ..|:||||........:.:..|.| |:...|..:|...|||........|..|.....|:..|..
Zfish   613 LQPNSSSTQGQQRLVQAGHMQAVSVPMQTHTSLTTPFYSNPMMFSPNHGHRSQHDTHCQRNTHAD 677

  Fly   867 HHDNSNSSSNID-PLFNYREESN----DTSCS-----------QHLHSPS----------ITSKS 905
            :..:......:: |:....::||    .:.|:           |.:.:||          :...|
Zfish   678 YSQDGQLRMLLNQPMQTLVQDSNGGPQSSQCTSTIQQTKYPLEQQMMAPSFPVQQVNCNAVLVPS 742

  Fly   906 PEDSSLPSLCSPNS-LTQEDDFSFEAFAMRAPY-IPIDDDMPLL----------TETDLMWCPPE 958
            |..:| |.:...|| :|.:...::......||: :|:.......          |.|..::..|.
Zfish   743 PVFTS-PIMIPHNSFITHQTTPTYTTHPPVAPHSLPLQQPQQFFQMQPQGLIHGTPTQALFHTPS 806

  Fly   959 DLQTMVPKE--IDAIQ-QQLQQLQQQHHQQYAGN 989
                 ||::  :..:| ||.||.||.||...:||
Zfish   807 -----VPQQSTVGYVQPQQQQQQQQHHHHSQSGN 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	16/66 (24%)
		PAS	256..392	CDD:395786	34/136 (25%)
		PAS	265..>317	CDD:238075	17/51 (33%)
		PAS	404..505	CDD:238075	32/116 (28%)
npas2	NP_840084.1	bHLH-PAS_PASD1	34..103	CDD:381579	19/88 (22%)
		PAS	119..>203	CDD:395786	26/91 (29%)
		PAS_11	286..388	CDD:464214	30/101 (30%)