Protein Alignment sima and Met

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Alignment Length: 801
• Identity: 139/801 - (17%)
• Similarity: 255/801 - (31%)
• Gaps: 289/801 - (36%)

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            :|....|.:.||.|......||:..:|...:...:|||.:|:|.....|:::.:.....|.|...
  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102

  Fly   225 DDIKQDIETAEDQQEV-KPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEY 288
            ..:|....:|....:: .|.|.:           .:.|.|.:|...|.|:..|.|..||.:|.:.
  Fly   103 TGLKGTGMSASPVGDLPNPSLHL-----------TDTLMQLLDCCFLTLTCSGQIVLVSTSVEQL 156

  Fly   289 LGITKIDTLGQQIWEYSHQCDHAEIK--------EALSLKRELAQKVKDEPQQNS---GVSTHHR 342
            ||..:.|..||.:.:.:|..|...::        |.|..:.:..|:....|||:|   ..||...
  Fly   157 LGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGHNPQQHSTSTSASTSGS 221

  Fly   343 DL--------------------------------------------------------------- 344
            ||
  Fly   222 DLEEEEMETEEHRLGRQQGEADDDEDHPYNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARAST 286

  Fly   345 ----------------FVRLKCTLTS--------------RGRSINIKSASYKV----------- 368
                            |.|...:||.              |.|:.|:.:|:..|
  Fly   287 RAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQH 351

  Fly   369 -------IH-ITGHLVVNAKGERLLM----------AIGRPI---PHPSNIEIPLGTSTFLTKHS 412
                   :| |:|:.:|.....|:|.          .:|..|   |.|..:|       :.|:|.
  Fly   352 DAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLE-------YHTRHL 409

  Fly   413 LDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSV--LSKGQGETSRYRFLGK 475
            :|......|.::..:.||...::.:.|.|...|..|...::...:.:  .:...|| |.||.|.:
  Fly   410 IDGSIIDCDQRIGLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGE-SCYRLLSR 473

  Fly   476 YGGYCWILSQATIVYDK--LKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEK 538
            .|.:.::.::..:..|:  .|..|.:|||.::.....:.::         .|.||:.....:.|.
  Fly   474 NGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKV---------QEMKEKFSTIIKAEM 529

  Fly   539 EPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLES------EKAEKTIEETKTIATIPPVTAT 597
             |.:::.|::.|.:.                |.|||.      |..:|:::..:|:.
  Fly   530 -PTQSSSPDLPASQA----------------PQQLERIVLYLIENLQKSVDSAETVG-------- 569

  Fly   598 STADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLR 662
                  .|..||            :..:.:|....|:|.:.|:.|
  Fly   570 ------GQGMES------------LMDDGYSSPANTLTLEELAPS-------------------- 596

  Fly   663 PSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSK 727
            |:||..|.||                      |.:::.||.::.:.:...|..:..||..|
  Fly   597 PTPALALVPP----------------------APSSVKSSISKSVSVVNVTAARKFQQEHQ---- 635

  Fly   728 GFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTT 792
                            |:...|..         ||.|.|..:..::..:.:||...:..|...:.
  Fly   636 ----------------KQRERDRE---------QLKERTNSTQGVIRQLSSCLSEAETASCILSP 675

  Fly   793 CSTTASGQHYQSPSSSSTSAP 813
            .|:.::.:...:|...|.::|
  Fly   676 ASSLSASEAPDTPDPHSNTSP 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	14/55 (25%)
		PAS	256..392	CDD:395786	44/268 (16%)
		PAS	265..>317	CDD:238075	16/59 (27%)
		PAS	404..505	CDD:238075	23/104 (22%)
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	14/50 (28%)
		PAS	137..>186	CDD:238075	14/48 (29%)
		PAS_11	401..510	CDD:464214	24/116 (21%)