Protein Alignment sima and Npas2

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_038939510.1
• Gene: Npas2 / 316351
• RGDID: 1309681
• Length: 855
• Species: Rattus norvegicus
• Alignment Length: 1014
• Identity: 217/1014 - (21%)
• Similarity: 358/1014 - (35%)
• Gaps: 302/1014 - (29%)

  Fly   151 EDFMNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQ 215
            ||..:..||..:::...: ||.:...:..|||:.||..|   .:|||.:|:...|.||:
  Rat     3 EDEKDRAKRASRNKSEKK-RRDQFNVLIKELSSMLPGNT---RKLDKTTVLEKVIGFLQ------ 57

  Fly   216 FVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITY 280
                   .::::....|..:.||:.||       .:|:..|..:|:.:.:|||::|::.:|.|.|
  Rat    58 -------KHNEVSAQTEICDIQQDWKP-------SFLSNEEFTQLMLEALDGFVIVVTTDGSIIY 108

  Fly   281 VSENVVEYLG---------------------------------------ITKIDTLGQQIWEYSH 306
            ||:::...||                                       :.:.|.:.|.:..:..
  Rat   109 VSDSITPLLGHLPGTEEESMKGLHRSRTLRLCLRSEVHPVERASFSLYFLLQSDVMDQNLLNFLP 173

  Fly   307 QCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLKCTLTSRGRSINIKS-ASYKVIH 370
            :.:|:|:.:.||..    ..|.|.|......|.:..:.:..|     .|| |:|.|. .:|:.|.
  Rat   174 EQEHSEVYKILSSH----MLVTDSPSPEFLKSDNDLEFYCHL-----LRG-SLNPKEFPTYEYIK 228

  Fly   371 ITGHL-----VVNAKGERLLMAIGRPIPHPSNIE------IPLGTSTFL--------------TK 410
            ..|:.     |.:.........:.||...|...|      :.|.|..||              ::
  Rat   229 FVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKEMCVADEPLEEFTSR 293

  Fly   411 HSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGK 475
            |||:.:|.::|.:...::||.|.::|.||.:...|..|.|.|....:.::..|:|::..||||.|
  Rat   294 HSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTK 358

  Fly   476 YGGYCWILSQATIVYDK--LKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQ--KEQHHQAAET 536
            ...:.|:.:...|.|.:  .||:.:||.:.|:|..:.:.|    .:|..|.|.  .|..|.:|..
  Rat   359 GQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVE----RRQELALEDPPTEAMHPSALK 419

  Fly   537 EKEPEKAADPEIIAQE--TKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIA----TIPPVT 595
            ||:......|...|.:  .....::|..::..::......:..:|.|...||.:|    |..|.:
  Rat   420 EKDSSLEPQPHFNALDMGASGLTSSPSPSASSRSSHKSSHTAMSEPTSTPTKLMAENSTTALPRS 484

  Fly   596 ATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASV 660
            ||        ||:..|.:.:.||             .|:.|.|||.||..|           |..
  Rat   485 AT--------LPQELPVQGLSQA-------------ATMPAPLLSSSSCDL-----------AKQ 517

  Fly   661 LRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDM 725
            |.|...|                                            ||.||:|..|....
  Rat   518 LLPQSLP--------------------------------------------QTVLQSPPAPVTQF 538

  Fly   726 SKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDIN---S 787
            |..| |:|       ..:|::.:..:..|.:....|.:|:....:.|      ||: :|.|   .
  Rat   539 SAQF-SMF-------QTIKDQLEQRTRILQANIRWQQEELHKIQEQL------CLV-QDSNVQMF 588

  Fly   788 LDSTTCSTTASGQH---YQSPSSSSTSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSHQQQQQ 849
            |.....|.:.||..   .|.|.....||||.             .||..|:.......|.|...|
  Rat   589 LQQPAVSLSFSGAQRPAAQQPLQQRPSAPSQ-------------PPLVVNTPLPGQITSTQVTNQ 640

  Fly   850 HHNQQQQQQQQQQHHPQHHD-----NSNSSSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDS 909
            |..::......|...|....     :|.|.|::...|     |:..|......|.:..:.:|:|:
  Rat   641 HLLRESNVMSAQGPKPIRSSQLLPASSRSLSSLPSQF-----SSTASVLPPGLSLTTVAPTPQDT 700

  Fly   910 SLPSLCSPNSLTQEDDFSFEAFAMRAPYIPIDDDMPLLTETDLMWCPPEDLQTMVPKEIDAIQQQ 974
               |.|.|:     .||..            |..:.||..        :.:|.|:|...||.|
  Rat   701 ---SQCQPS-----PDFGH------------DRQLRLLLS--------QPIQPMMPGSCDARQ-- 735

  Fly   975 LQQLQQQHHQQYAGNTGYQQQQQQPQL----QQQHFSNSLCSS--------------PASTVSSL 1021
                     ......||.|.:..|.|:    ...|.::|...:              |||..|.|
  Rat   736 ---------PSEVSRTGRQVKYAQSQVTFPSPDSHPTSSSAPTPVLLMGQAVLHPGFPASQPSPL 791

  Fly  1022 SPSPVQQ------------HHQQQQAAVFTSDSSELAAL 1048
            .|:.|||            |.:|..:.:.::.|.:.|.|
  Rat   792 QPTQVQQQPPPYLQAPTSLHSEQPDSLLLSTFSQQPAPL 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	16/56 (29%)
		PAS	256..392	CDD:395786	34/180 (19%)
		PAS	265..>317	CDD:238075	15/90 (17%)
		PAS	404..505	CDD:238075	32/116 (28%)
Npas2	XP_038939510.1	bHLH-PAS_NPAS2_PASD4	1..77	CDD:381580	22/90 (24%)
		PAS	84..234	CDD:395786	32/159 (20%)
		PAS_11	288..391	CDD:464214	30/102 (29%)