Protein Alignment sima and Sim1

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001101111.1
• Gene: Sim1 / 309888
• RGDID: 1309949
• Length: 765
• Species: Rattus norvegicus
• Alignment Length: 937
• Identity: 227/937 - (24%)
• Similarity: 363/937 - (38%)
• Gaps: 227/937 - (24%)

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            ||||::|||.||.||...|.||:..|||.:...:||||||::|:|.::||:|  :.|...|.
  Rat     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMR--VVFPEGLG--- 61

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEAREL---LKQTMDGFLLVLSHEGDITYVSENVV 286
                   |.........|...||          |||   |.||:|||:.|::.:|.|.|:||...
  Rat    62 -------EAWGHTSRTSPLDNVG----------RELGSHLLQTLDGFIFVVAPDGKIMYISETAS 109

  Fly   287 EYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTH--HRDLFVRLK 349
            .:||:::::..|..|:||.|..||.|:...|:         ..:|..:..|..:  .|..|:|:|
  Rat   110 VHLGLSQVELTGNSIYEYIHPADHDEMTAVLT---------AHQPYHSHFVQEYEIERSFFLRMK 165

  Fly   350 CTLTSRGRSINIKSASYKVIHITGHLVVNAKGERL-----------LMAIGRPIPHPSNIEIPLG 403
            |.|..  |:..:....|||||.:|:|.:......:           |:|:|..:|..:..||.|.
  Rat   166 CVLAK--RNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLH 228

  Fly   404 TSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETS 468
            ::.|:.:.||||:..::|.::.:|.||.|:||::.:|:...||.|:..|......:|.|||..|.
  Rat   229 SNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTK 293

  Fly   469 RYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHH 531
            .||||.|:||:.|:.|.||||::  ..:|..:|.||||:::.|.|....||.|.:
  Rat   294 YYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQIS---------- 348

  Fly   532 QAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTA 596
                    |.|   |..    :..:.:||..|...:....:|.|.|::.
  Rat   349 --------PSK---PTF----SYTSSSTPTITDNRKGAKSRLSSSKSKS---------------- 382

  Fly   597 TSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGL---RPEEKRPKSVTA 658
                       .::||.|.                            ||.   |.|.........
  Rat   383 -----------RTSPYPQY----------------------------SGFHTERSESDHDSQWGG 408

  Fly   659 SVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQP-- 721
            |.|..:.:|.|               ::|..|           .|..:|..|.:   |.|.:.
  Rat   409 SPLTDTASPQL---------------LDPERP-----------GSQHELSCAYR---QFPDRGSL 444

  Fly   722 ----AQDMS-----KGFCSLFADDGR---GLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVG 774
                |.|.|     :.|.:...:.||   |...|...|........|...:.|.:.:|.|.....
  Rat   445 CYGFALDHSRLVEDRHFHTQACEGGRCEAGRYFLGAPPAGRDPWWGSRAALPLTKASPESRETYE 509

  Fly   775 LMGTCLLPEDINSLDSTTCSTTASGQ-HYQSPSSSSTSAPSNTSSS-----NNSYANSPLSPLTP 833
                       ||:...|......|: |:...|..|:..|.:.|.|     :..|.|||..|...
  Rat   510 -----------NSMPHITSVHRLHGRGHWDEDSVVSSPDPGSASESGDRYRSEQYQNSPHEPSKI 563

  Fly   834 NSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQHHDNSNSSSNIDPL--FNYREESNDTSCSQHL 896
            .:...|:       ||...:::.:.|.::..|....:.|.:.....|  .||::   .....:..
  Rat   564 ETLIRAT-------QQMIKEEENRLQLRKAPPDQLASINGAGKKHSLCFANYQQ---PPPAGEVC 618

  Fly   897 HSPSITSKSPED---SSLPSLCSPNSLTQEDDFSFEAFAMRAPYIPIDDDMPLLTETDLMWCPPE 958
            ||.::||.||.|   .....:.||:    |:|:.....|:.....|..|   .:|::.|:.....
  Rat   619 HSSALTSTSPCDHIQQREGKMLSPH----ENDYDNSPTALSRISSPSSD---RITKSSLILAKDY 676

  Fly   959 DLQTMVPKEIDAIQQQLQQLQQQHHQQYAGN-----TGYQQQQQQPQLQQQHFSNSLCSSPASTV 1018
            ....|.|.:.......:.......|:||...     |||..:........:::|.. |:.....|
  Rat   677 LHSDMSPHQTAGDHPAISPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLG-CNGSHFDV 740

  Fly  1019 SS---LSPSPVQQHHQQQQAAVFTSDS 1042
            :|   :.|.|.|.|  :..:.:.|:.|
  Rat   741 TSHLRMQPDPAQGH--KGTSVIITNGS 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	28/55 (51%)
		PAS	256..392	CDD:395786	45/151 (30%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	40/102 (39%)
Sim1	NP_001101111.1	bHLH-PAS_SIM1	1..71	CDD:381581	31/80 (39%)
		PAS	88..>158	CDD:238075	22/78 (28%)
		PAS_3	243..329	CDD:430001	32/85 (38%)
		SIM_C	359..668	CDD:461963	76/420 (18%)