Protein Alignment sima and ahr2

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_571339.1
• Gene: ahr2 / 30517
• ZFINID: ZDB-GENE-990714-16
• Length: 1027
• Species: Danio rerio
• Alignment Length: 1101
• Identity: 217/1101 - (19%)
• Similarity: 365/1101 - (33%)
• Gaps: 350/1101 - (31%)

  Fly   157 EKRKE--------------KSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAF 207
            :|||:              ||..:.|.|....:|: .:|:..||...|...:|||.||:|:::.:
Zfish    11 KKRKKPVQKIPKPPPPDGVKSNPSKRHRDRLNSEL-DKLTNLLPFSEDVRARLDKLSVLRLSVGY 74

  Fly   208 LKIREMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWL---------NGAEAR----- 258
            ||::...         |..||                :.|...||         ||..|.
Zfish    75 LKVKSFF---------NATIK----------------KTGGNGWLNDRSGTFGGNGQTASSLDGV 114

  Fly   259 -----ELLKQTMDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSH------------ 306
                 |||.|.::||:||::.||.:.|.|..:.:|||..:.|.:...::|..|
Zfish   115 NFSEGELLLQALNGFVLVVTAEGYVFYSSPTIQDYLGFHQSDVVHHSVFELIHTDDRAMFRRQLH 179

  Fly   307 -----QCDHAEIKEALSLKRELAQKV-----KDEPQQNSGVSTHHRDLFVRLKCTL--TSRGRSI 359
                 ..|.|:..||:....::.:.:     :..|.:||  |...|....|.:|.|  :|...::
Zfish   180 FALNPSSDSADGSEAMQSSSDITRDMVNYNPQHIPPENS--SFLERSFCCRFRCLLDNSSGFLAL 242

  Fly   360 NIKSASYKVIHITGHLVVN---AKGERLLMAIGRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVD 421
            |.: ...|.:|....|..:   |..:..|..|..|:..||.:||...|..|.|||.||.....:|
Zfish   243 NFQ-GRLKYLHGQNKLAEDGTLAHPQLALFIIATPLQPPSILEIRSKTLLFQTKHKLDFTPMGID 306

  Fly   422 DKMHDLLGYSPKDL-LDTSLFSCQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQ 485
            .:...:|||:..:| :..|.:...|.||..........::..|:...:.:|.|.|.|.:.|:.:.
Zfish   307 TRGKVVLGYTEIELCMRGSGYQFIHAADMMYCADNHIRMIKTGESGLTVFRLLSKGGTWIWVQAN 371

  Fly   486 ATIVYDKLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIA 550
            |.:||...:|..::                  |:|.|.:.::.:.|......:.|...|..|.:.
Zfish   372 ARLVYKAGRPDFII------------------ARQRALTNEEGEEHLRQRKLQLPFNCATGEGVL 418

  Fly   551 QETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQI 615
            .|...|::    .:|:|      ...|.:|.:.        ||           .|...:....:
Zfish   419 YEVGPTLD----VAEIQ------NQSKGQKMLN--------PP-----------SLDPDSLLGSM 454

  Fly   616 LQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKK 680
            |:.:..:..:|:.|..: .|.....|.|..|       .:|..:..:||  .|.|.|
Zfish   455 LKQDHSLYSQNNDPNSQ-FTIDKAFGDSHAL-------LNVPGNTWQPS--TPNTVP-------- 501

  Fly   681 TPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMS----------KGFCSLFAD 735
               |::..         |::....:.||  |..::.|.....:|.:          ...|.:..:
Zfish   502 ---GIKEE---------AVVKDMLETLQ--QIIEVGNNCNSLEDFNLDRMELKEWENTLCRMNYN 552

  Fly   736 DGRGLTMLKEEPDDLSH---HLASTNCIQ-LDEMTPFSDMLVGL--------------------- 775
            :...:..:..| |..|:   .|...|.|| |.::.|||:|..||
Zfish   553 NDMEINEIITE-DIFSYVEDVLFKENGIQPLKDLGPFSEMSEGLSELELQNNLAANQEFSCQAGV 616

  Fly   776 ---------------------------------MGTCLLPED--INS--LDSTTCSTTASG---- 799
                                             ||..:||.:  |.|  ||.||.....:.
Zfish   617 HGGSPGQGGFIGMNIQEGMDTSSPGRGTVKLSHMGPQMLPGNNFIQSFGLDQTTQKMAGNSNILF 681

  Fly   800 ------QHYQSPSSSSTS-------------APSNTSSSNNSYANSPLSPL-TPNSTATASNPSH 844
                  |..|.|:..:..             ...|..:.|..:.|:...|| :|....|::.|..
Zfish   682 RPSLAMQQSQQPNQVNLGLQGVVQENGIVPCGQRNLLTGNQPHPNTMTLPLQSPLVQGTSTQPMG 746

  Fly   845 QQQQQHHNQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSCSQH--------LHS--- 898
            .:.|....||....|..|..|      :|:|.:|...|        ||:.:        |||
Zfish   747 FRNQNSLPQQPSISQNPQWVP------SSNSVVDNRMN--------SCAHNVSGPQDAGLHSGPF 797

  Fly   899 -------------------PSITSKSPEDSSLPSLCS----PNSLTQEDDFSFEAFAMRAPYIPI 940
                               |......|....:|:..|    |..::|..||.........|:
Zfish   798 ANLQGQFSLHTQNAANAGPPGWQQSQPTPQGVPTSFSGGHQPGFISQVTDFQRGTLNQMMPH--- 859

  Fly   941 DDDMPLLTETDLM---WCPPEDLQTMVPKEIDAIQQQLQQLQQQHHQQYAGNTGYQ-QQQQQPQL 1001
                   |....:   :.|.|....:.|::.|.|          ::..:..:|... ....||.:
Zfish   860 -------TNGQGIGSGFLPKESASAIYPQQGDFI----------NNSPHKTSTSCMFMNNAQPSV 907

  Fly  1002 Q-QQHFSNSLCSSPAS---TVSSLSPSPVQQHHQQQQ--------AAVFTSDSSELAALLC 1050
            . .|:.|..|.|..:|   |...|:.||.|.....|:        .||...:.:.::.:.|
Zfish   908 NGMQYGSADLVSGMSSCQGTKGLLTQSPTQASCYFQRGPSETIVGTAVIPQEDNNISPMAC 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	19/70 (27%)
		PAS	256..392	CDD:395786	39/172 (23%)
		PAS	265..>317	CDD:238075	17/68 (25%)
		PAS	404..505	CDD:238075	26/101 (26%)
ahr2	NP_571339.1	bHLH-PAS_AhR_like	27..85	CDD:381539	18/67 (27%)
		PAS	120..183	CDD:214512	18/62 (29%)
		PAS_3	312..386	CDD:430001	18/91 (20%)
		Med15	<600..>832	CDD:312941	39/245 (16%)