Protein Alignment sima and Sim2

DIOPT Version :9

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001100578.1
• Gene: Sim2 / 304071
• RGDID: 1308016
• Length: 656
• Species: Rattus norvegicus
• Alignment Length: 646
• Identity: 179/646 - (27%)
• Similarity: 281/646 - (43%)
• Gaps: 136/646 - (21%)

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            ||||::||:.||.||...|.||:..|||.:...:||||||::|:|.::||:|.:  |...|.|
  Rat     2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAV--FPEGLGD-- 62

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEAREL---LKQTMDGFLLVLSHEGDITYVSENVV 286
                     |..|......|:         :.|:||   |.||:|||:.|::.:|.|.|:||...
  Rat    63 ---------AWGQPSRTGPLD---------SVAKELGSHLLQTLDGFVFVVASDGKIMYISETAS 109

  Fly   287 EYLGITKIDTLGQQIWEYSHQCDHAEIKEALS----LKRELAQKVKDEPQQNSGVSTHHRDLFVR 347
            .:||:::::..|..|:||.|..||.|:...|:    |...|.|:.:.|           |..|:|
  Rat   110 VHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPPLHHHLLQEYEIE-----------RSFFLR 163

  Fly   348 LKCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERL-----------LMAIGRPIPHPSNIEIP 401
            :||.|..  |:..:..:.|||||.:|:|.:......:           |:|:|:.:|..:..||.
  Rat   164 MKCVLAK--RNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIK 226

  Fly   402 LGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGE 466
            |..:.|:.:.|||::..::|.::.:|.||.|:||::.:|:...||.|:..|......:|.|||..
  Rat   227 LHNNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVT 291

  Fly   467 TSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQ 529
            |..||.|.|.||:.|:.|.||:|::  ..:|..:|.||||::.:|.| |:.....|.:.|:.:|.
  Rat   292 TKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEVEYK-ELQLSLDQVSTSKSQES 355

  Fly   530 HHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPL-QLESEKAEKTIEETKTIATIPP 593
            ......|.:|..|:|.|:.....||...| |..:.:..:..: :||..:|........|.|..||
  Rat   356 WRTTLSTSQETRKSAKPKTTKMRTKLRTN-PYPSQQYSSFQMDKLECSQAGNWRTSPPTSAVAPP 419

  Fly   594 VTA--TSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSV 656
            ...  :..:|.:...|.|.|:..         |..|.|    :.:.:.|....||..:..:|:..
  Rat   420 EQQLHSEASDLLYGPPYSLPFSY---------RYGHFP----LDSHVFSSKKPGLPAKFGQPQGS 471

  Fly   657 TASVLR------------------------PSPAPPLTPPPTAVLCKKTPLGVEPNL-PPTTTA- 695
            ...|.|                        ||||..|:..|.    .....|:.||. .|..||
  Rat   472 PCEVARFFLSTLPASSECQWHYANSLMPSSPSPAKNLSESPV----NAARHGLVPNYEAPAATAR 532

  Fly   696 ---------------------------TAAIISSSNQQLQIAQQT------QLQNPQQPAQ 723
                                       .|...|....:|.:|:.|      ....||.|||
  Rat   533 RFGEDPAPSSFPSCGHYREEPTLGSAKAARQASRDTARLALARATPECCAPPAPEPQAPAQ 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	24/48 (50%)
		PAS	256..392	CDD:279347	47/153 (31%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	37/102 (36%)
		PAS_3	417..502	CDD:285623	30/86 (35%)
Sim2	NP_001100578.1	HLH	2..52	CDD:238036	25/49 (51%)
		PAS	79..>141	CDD:279347	24/61 (39%)
		PAS	79..140	CDD:214512	24/60 (40%)
		PAS	230..328	CDD:238075	34/97 (35%)
		PAS_3	243..329	CDD:285623	30/85 (35%)
		SIM_C	359..649	CDD:284122	51/253 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351081
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840