Protein Alignment sima and Bmal1

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_017444554.1
• Gene: Bmal1 / 29657
• RGDID: 62003
• Length: 633
• Species: Rattus norvegicus
• Alignment Length: 699
• Identity: 155/699 - (22%)
• Similarity: 265/699 - (37%)
• Gaps: 193/699 - (27%)

  Fly   111 GSLLNVATPCRESRPWSYAYCYGYAPTNTQ--PCQFSQFVDIE--------DFMNNEKRKEKSRD 165
            |||......|...|..|        .|:.|  ...|.:.:|.:        ::..::.|.:.:|:
  Rat    26 GSLSTSGVDCNRKRKGS--------ATDYQLDDFAFEESMDTDKDDPHGRLEYAEHQGRIKNARE 82

  Fly   166 A----ARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCNDD 226
            |    .:.||.|......||::.:|.......:|||.:|:|:.:..:|         :||...:.
  Rat    83 AHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMK---------TLRGATNP 138

  Fly   227 IKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLS-HEGDITYVSENVVEYLG 290
            .        .:...||       .:|:..|.:.|:.:..||||.|:. ..|.|.:|||:|.:.|.
  Rat   139 Y--------TEANYKP-------TFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILN 188

  Fly   291 ITKIDTLGQQIWEYSHQCDHAEIKEALS------------LKRELAQKVKDEPQQNSGVSTHHRD 343
            .::.|.:||.:::|.|..|.|::||.||            .|..|..|....|..:...|...|.
  Rat   189 YSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRS 253

  Fly   344 LFVRLKCTLTS-------RGRSINIKSA---SYKVIHITGHL--------------VVNAKGERL 384
            .|.|:||...|       ...:.:.|.|   |:..||.||:|              ..:.:|..|
  Rat   254 FFCRMKCNRPSVKVEDKDFASTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDSEPDNEGCNL 318

  Fly   385 --LMAIGR----PIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSC 443
              |:||||    .:|.|.|.||.:.:..::::|::|.:|.:||.:...:|.|.|::||.||.:..
  Rat   319 SCLVAIGRLHSHMVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEY 383

  Fly   444 QHGADSERLMATFKSVL-SKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISN 507
            .|..|...|....:.|| ::.:..|:.|:|..|.|.:..:.|:   .:..:.|.:.. |.|::|.
  Rat   384 FHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSR---WFSFMNPWTKE-VEYIVST 444

  Fly   508 ----LENKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQA 568
                |.|..|                             ..||..               .:|.|
  Rat   445 NTVVLANVLE-----------------------------GGDPTF---------------PQLTA 465

  Fly   569 KPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRT 633
            .|..::|..........:|..|:|.:...:.|.       :....:::..|::   |.|.
  Rat   466 SPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAG-------AGKIGRMIAEEIM---EIHR----- 515

  Fly   634 ITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAA 698
                 :.|||         |.|..:|.|..:..||  |..::...||...|..|::|     :|.
  Rat   516 -----IRGSS---------PSSCGSSPLNITSTPP--PDASSPGGKKILNGGTPDIP-----SAG 559

  Fly   699 IISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGR-GLTMLKEE 746
            ::...      ||:|    |..|..|.|    |:..::.. |:.|:..:
  Rat   560 LLPGQ------AQET----PGYPYSDSS----SILGENPHIGIDMIDND 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	15/60 (25%)
		PAS	256..392	CDD:395786	51/178 (29%)
		PAS	265..>317	CDD:238075	21/52 (40%)
		PAS	404..505	CDD:238075	26/101 (26%)
Bmal1	XP_017444554.1	bHLH-PAS_ARNTL_PASD3	74..137	CDD:381444	17/71 (24%)
		PAS	156..215	CDD:214512	22/58 (38%)
		PAS_11	346..448	CDD:464214	27/105 (26%)