Protein Alignment sima and Epas1

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_063117652.1
• Gene: Epas1 / 29452
• RGDID: 68404
• Length: 974
• Species: Rattus norvegicus
• Alignment Length: 986
• Identity: 267/986 - (27%)
• Similarity: 422/986 - (42%)
• Gaps: 254/986 - (25%)

  Fly   155 NNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPS 219
            ::|.||||||||||||||||||:|.||:..|||.....:.|||||:||:.|:||:..::|..|
  Rat    87 SSELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSV-- 149

  Fly   220 LRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSEN 284
               |:::   :.|...|||                  ...|..:.::||:.|::.:||:.::|||
  Rat   150 ---CSEN---ESEAEADQQ------------------MDNLYLKALEGFIAVVTQDGDMIFLSEN 190

  Fly   285 VVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLK--RELAQKVKDEPQQNSGVSTHHRDLFVR 347
            :.:::|:|:::..|..|::::|.|||.||:|.|:||  ....:|.||       :|| .||.|:|
  Rat   191 ISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLKTGSGFGKKNKD-------MST-ERDFFMR 247

  Fly   348 LKCTLTSRGRSINIKSASYKVIHITG----------HLVVNAKGERL---LMAIGRPIPHPSNIE 399
            :|||:|:|||::|:|||::||:|.||          |..:....|.|   |:.:..||.|||:::
  Rat   248 MKCTVTNRGRTVNLKSATWKVLHCTGQVRVYNNCPPHSSLCGYKEPLLSCLIIMCEPIQHPSHMD 312

  Fly   400 IPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQ 464
            |||.:.|||::||:||:|||.||::.:|:||.|::||..|.:...|..|||.:..:.:::.:|||
  Rat   313 IPLDSKTFLSRHSMDMKFTYCDDRILELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQ 377

  Fly   465 GETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQK 527
            ..:.:||.|.|:|||.|:.:|.|:||:  .|:||.::|||||:|.:|....::|:.|
  Rat   378 VVSGQYRMLAKHGGYVWLETQGTVVYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQ-------- 434

  Fly   528 EQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAE----KTIEETKTI 588
                        .|....|.::|      :|:...:|:..|.     |||:.    |..||.:.:
  Rat   435 ------------TESLFKPHLMA------MNSIFDSSDDVAL-----SEKSNYLFTKLKEEPEDL 476

  Fly   589 ATIPPVTATSTADQI-------KQLPESNPY-KQILQAELLIKRENHSPGPRTITAQLLSGSSSG 645
            |.:.|    :..|.|       :...||:.| |.||           .||....| :|.|.|:
  Rat   477 AQLAP----TPGDAIISLDFGSQNFDESSTYGKAIL-----------PPGQPWAT-ELRSHSA-- 523

  Fly   646 LRPEEKRPKSVTASVLRPSPAP-PLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQI 709
                :...:|:.|..:..:.:| ..||..|:.....||...|.           ..||....|:|
  Rat   524 ----QSESRSLPAFTVPQAGSPGNATPSATSSSSCSTPSSPED-----------YYSSLENHLKI 573

  Fly   710 AQQTQLQNPQQPAQDMSKGFCSLFAD---------------DGRGL---------TMLKEEPDDL 750
            ....:|......|:|.    ||...|               ||...         .::.|.|...
  Rat   574 EVIEKLFAMDTEAKDQ----CSTQTDFNELDLETLAPYIPMDGEDFQLSPICPEEPLVPESPQPN 634

  Fly   751 SHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDS----------TTCSTTASGQHYQSP 805
            ..|..||.......:||.:.     .||..|.:....|:|          :|....|..:....|
  Rat   635 PQHCFSTMSSIFQPLTPGAS-----QGTFFLDKYPQQLESRKTESEHWPMSTIFFDAGSKGSLPP 694

  Fly   806 SSSSTSAP-------SNT----------SSSNNSYANSPLSPLTPNSTATA-----SNPSHQQQQ 848
            .....|.|       |||          ..:..|..|....||.|....|:     |.|.|....
  Rat   695 CCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWSVGNQSAEPLGPLPLGTSQLEPPSTPPHVSMF 759

  Fly   849 QHH---------------------NQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSC 892
            :..                     |:.:.::|.....|...|.|..    ||         ..:.
  Rat   760 KMRSAKDFGARGPYMMSPAMIALSNKLKLKRQLDYEEPAFQDTSGG----DP---------PGTS 811

  Fly   893 SQHL---HSPSI---TSKSPEDSSLPSLCSPNSLTQEDDFSFEAFAMRA---PYIPIDDDMPLLT 948
            |.||   ...|:   |.....|.::.:..:|:..||:        :||.   |...:....|..|
  Rat   812 SSHLMWKRMKSLMGGTCPLMPDKTVSASMAPDEFTQK--------SMRGLGQPLRHLPPSQPPST 868

  Fly   949 ETDLMWCPPEDLQTMVPKEIDAIQQQLQQLQQQHHQQYAGNTGYQQQQQQPQLQQQHFSNSLCSS 1013
            .:     |.|:.::..|.:..|  ...|.......|:.:||....::...|::.:....:.||..
  Rat   869 RS-----PGENAKSGFPPQCYA--SPFQDYSPPGAQKGSGNGAQGERAAAPEVARSWRHSCLCER 926

  Fly  1014 P---ASTVSSL 1021
            |   :|||.|:
  Rat   927 PPPWSSTVESV 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	35/56 (63%)
		PAS	256..392	CDD:395786	52/150 (35%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	45/102 (44%)
Epas1	XP_063117652.1	None