DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and Npas3

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	XP_036013330.1	Gene:	Npas3 / 27386	MGIID:	1351610	Length:	1247	Species:	Mus musculus

Alignment Length:	1014	Identity:	237/1014 - (23%)
Similarity:	395/1014 - (38%)	Gaps:	258/1014 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DVIP----GSSFYECDSKPQR--QRQLSRNGPAFGPMPINEPT-----------VNFGNGSFYNG 69
            ||.|    |..::...|:.|:  :|...|:|...|..|...|:           .:....:....
Mouse   225 DVRPPATLGPHYFPVASQAQQRGRRHRRRHGHGHGRRPPGPPSAAHARTLSRQPTHTHTPALPTP 289

  Fly    70 PAPGSQPFVGAMLGPNMSSTGMQRYHPYHQQQPQDAFYRQRGSL---LNVATPCRESRPWSYAYC 131
            ||||.    |:...........::..|......||...|:|.:.   |...:.||:...:...||
Mouse   290 PAPGG----GSEAKSKRGKKNCRKMAPTKPSFQQDPSRRERITAQHPLPNQSECRKIYRYDGIYC 350

  Fly   132 YGYAPTNTQPCQFSQFVDIEDFMNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLD 196
            .            |.:.:::..     ||||||||||.||.||...|.||:..|||.....:|||
Mouse   351 E------------STYQNLQAL-----RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLD 398

  Fly   197 KASVMRITIAFLKIREML-QFVP--SLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLN----- 253
            |||::|:||::||:|:.. |..|  :||         :|.......||     |.:.|.:
Mouse   399 KASIIRLTISYLKMRDFANQGDPPWNLR---------MEGPPPNTSVK-----GIQMWKSELCMR 449

  Fly   254 -------GAEAREL----------------LKQTMDGFLLVLSHEGDITYVSENVVEYLGITKID 295
                   ||:.|..                :.|::|||:..|:.||...|:||.|..|||:::::
Mouse   450 KTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVE 514

  Fly   296 TLGQQIWEYSHQCDHAEIKEALSLK----REL----------------AQKVKDEPQQNSGVS-- 338
            ..|..:::|.|..||.|:.|.|.:|    |.|                :|....||.:.:..|
Mouse   515 LTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTTEDAASSASSSSQSETPEPVETTSPSLL 579

  Fly   339 ----THHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHL---VVNAKGERL------LMAIGR 390
                |..|..|:|:|.|||.||  ::|||:.||||||||.|   |..:.|..:      |:.:..
Mouse   580 TTDNTLERSFFIRMKSTLTKRG--VHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAH 642

  Fly   391 PIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMAT 455
            .:|.|:..|:.:....|:|:.::|:...|.::::.|.:..:|.|::....:...|..|.|.:..:
Mouse   643 ALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHS 707

  Fly   456 FKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLA 518
            ...:|:|||..|..||::.|.|||.||.|.|||..:  ....::::.|||::||.|.|.....:|
Mouse   708 HLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIA 772

  Fly   519 Q------------QTAASE-----------QKEQHHQAAETEKEPEKAADPEIIAQETKETVNTP 560
            |            :|:.||           :..::.::.|...:.|.:.|||...:::....:..
Mouse   773 QLPHLPEKASESSETSDSESDSKDTSGITAEDNENSKSDEKGNQSENSEDPEPDRKKSGSACDND 837

  Fly   561 IHTSE---LQAKPLQLESE--------------------------KAEKTIEETKTIATIPPVTA 596
            ::.::   ..:.|...:|:                          |.|:.:|....:...|..:.
Mouse   838 MNCNDDGHSSSNPDSRDSDDSFEHSDFEHPKAAEDGFGALGPMQIKVERYVESEADLRLQPCESL 902

  Fly   597 TSTADQIKQLPESNPYKQILQA----ELLIKRENHSPGPRTITAQLLSGSSSGL-----RPEE-- 650
            ||  |..|....:|  :...||    :...:|.....|......:|.|.||.||     .|..
Mouse   903 TS--DSAKDSDSAN--EAGAQASSKHQKRKRRRKRQKGGSASRRRLSSASSPGLDAGLVEPPRLL 963

  Fly   651 KRPKSVTASVLRPSPAPPLT----------PPPTAVLCKKTPLGVEPNLPPTTTATAAI-----I 700
            ..|.|.:...::...|.|:.          ||...:...::|..:  ..|||:....:.     .
Mouse   964 SSPHSASVLKIKTEIAEPINFDNDSSIWNYPPNREISRNESPYSM--TKPPTSEHFPSPQGQGGS 1026

  Fly   701 SSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHL----------- 754
            |.....|.:|....:..|  |..|.:.|..:.|:    |...:..:|  ||..|
Mouse  1027 SGGGGALHVAIPDSVLTP--PGADGTAGRKTQFS----GTAPVPSDP--LSPPLSASPRDKHPGG 1083

  Fly   755 ----------ASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSS 809
                      ||.:.:...::.....:..   |..:||. ::.:..|..:|:.:.|...: :.:.
Mouse  1084 GAGSGGGGPGASNSLLYTGDLEALQRLQA---GNVVLPL-VHRVTGTLAATSTAAQRVYT-TGTI 1143

  Fly   810 TSAPS------------NTSSSNNSYANSP---LSPLTP 833
            ..||:            |..:.|....|||   |.|.||
Mouse  1144 RYAPAEVTLAMQGNLLPNAHAVNFVDVNSPGFGLDPKTP 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	29/52 (56%)
		PAS	256..392	CDD:279347	55/186 (30%)
		PAS	265..>317	CDD:238075	20/51 (39%)
		PAS	404..505	CDD:238075	30/102 (29%)
		PAS_3	417..502	CDD:285623	24/86 (28%)
Npas3	XP_036013330.1	bHLH-PAS_NPAS3_PASD6	357..433	CDD:381575	37/89 (42%)
		PAS	478..536	CDD:214512	21/57 (37%)
		PAS_3	669..756	CDD:369881	24/86 (28%)
		MSCRAMM_ClfA	<762..>922	CDD:411231	25/163 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847525
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850