Protein Alignment sima and Bmal2

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_006507111.1
• Gene: Bmal2 / 272322
• MGIID: 2684845
• Length: 595
• Species: Mus musculus
• Alignment Length: 547
• Identity: 131/547 - (23%)
• Similarity: 228/547 - (41%)
• Gaps: 100/547 - (18%)

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            :|......:.||.|...:..:||:.:|......::|||.||:|..:.:|:         |||...
Mouse    50 REAHSQMEKRRRDKMNHLIQKLSSMIPPHIPTAHKLDKLSVLRRAVQYLR---------SLRGMT 105

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHE-GDITYVSENVVEY 288
                 ::...|:.   ||       .::...|...|:.:..:|||.|:..| |.|.|||::|.:.
Mouse   106 -----ELYLGENS---KP-------SFIQDKELSHLILKAAEGFLFVVGCERGRIFYVSKSVSKT 155

  Fly   289 LGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKD-------------EPQQNSGVSTH 340
            |...:...:||.::::.|..|.|::||.||......:|..|             .|:.:||   .
Mouse   156 LRYDQASLIGQNLFDFLHPKDVAKVKEQLSCDGSPREKPIDTKTSQVYSHPYTGRPRMHSG---S 217

  Fly   341 HRDLFVRLK-CTLTSRGR----SINIKS--ASYKVIHITGHL------VVNAKGE---------- 382
            .|..|.|:| ||:..:..    |.:.|.  ..:..:|.||:|      ||..:.|
Mouse   218 RRSFFFRMKSCTVPVKEEQPCSSCSKKKDHRKFHTVHCTGYLRSWPLNVVGMEKESGGGKDSGPL 282

  Fly   383 RLLMAIGR--P--IPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSC 443
            ..|:|:||  |  :|..|. :|.:..:.|:|:.:::.:|.|||.:...:|||.|::||.||.:..
Mouse   283 TCLVAMGRLHPYIVPQKSG-KINVRPAEFITRFAMNGKFVYVDQRATAILGYLPQELLGTSCYEY 346

  Fly   444 QHGADSERLMATFKSVL-SKGQGETSRYRFLGKYGGYCWILSQ---ATIVYDKLKPQSVVCVN-Y 503
            .|..|...|....|:|| ||.:..|..|:|..|.|.:..:.|:   .|..:.| :.:.:|.|| .
Mouse   347 FHQDDHSSLTDKHKAVLQSKEKILTDSYKFRVKDGAFVTLKSEWFSFTNPWTK-ELEYIVSVNTL 410

  Fly   504 VISNLENKHEIYSLAQQTAASE-----QKEQHHQAAETEKEPEKAADPEIIAQET---KETVNTP 560
            |:...|.:..:......:.:||     |..:.:..|.::...:...:...::..|   ..::.|.
Mouse   411 VLGRSETRLSLLHCGGSSQSSEGKTELQVRRGNSDASSDSFRQSCINVPGVSTGTVLGAGSIGTD 475

  Fly   561 IHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRE 625
            |....|..:.|...|.:.....||.:...::....|...|...:....|....::|:|    .|:
Mouse   476 IANEVLSLQRLHSSSPEDASPSEEVRDDCSVNGGNAYGPASTREPFAVSPSETEVLEA----ARQ 536

  Fly   626 N------HSPGPRTITAQLLSGSSSGL 646
            :      |..||       |.|.|:.|
Mouse   537 HQSTEPAHPHGP-------LPGDSAQL 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	14/55 (25%)
		PAS	256..392	CDD:395786	48/176 (27%)
		PAS	265..>317	CDD:238075	19/52 (37%)
		PAS	404..505	CDD:238075	33/105 (31%)
Bmal2	XP_006507111.1	bHLH_SF	49..108	CDD:469605	17/71 (24%)
		PAS	125..184	CDD:214512	20/58 (34%)
		PAS_11	309..411	CDD:464214	33/102 (32%)