DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and sim1a

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	NP_835740.2	Gene:	sim1a / 260351	ZFINID:	ZDB-GENE-020829-1	Length:	745	Species:	Danio rerio

Alignment Length:	803	Identity:	201/803 - (25%)
Similarity:	328/803 - (40%)	Gaps:	190/803 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCN 224
            ||||::|||.||.||...|.||:..|||.:...:||||||::|:|.::||:|  :.|...|.:..
Zfish     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMR--IVFPEGLGESW 64

  Fly   225 DDIKQ--DIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVE 287
            ..:.:  .:|..                   |.|....|.||:|||:.|::.:|.|.|:||....
Zfish    65 GHVSRTTSLENV-------------------GRELGSHLLQTLDGFIFVVAPDGKILYISETASV 110

  Fly   288 YLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTH--HRDLFVRLKC 350
            :||:::::..|..|:||.|..||.|:...|:         ..:|..:..|..:  .|..|:|:||
Zfish   111 HLGLSQVELTGNSIYEYIHPADHDEMTAVLT---------AHQPYHSHFVHEYEMERSFFLRMKC 166

  Fly   351 TLTSRGRSINIKSASYKVIHITGHLVVNAKGERL-----------LMAIGRPIPHPSNIEIPLGT 404
            .|..  |:..:....|||||.:|:|.:......:           |:|:|..:|..:..||.|.:
Zfish   167 VLAK--RNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHS 229

  Fly   405 STFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGETSR 469
            :.|:.:.||||:..::|.::.:|.||.|:||::.:|:...|..|:..|......:|.|||..|..
Zfish   230 NMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHSCDTFHLRCAHHLLLVKGQVTTKY 294

  Fly   470 YRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQHHQ 532
            ||||.|.||:.|:.|.||||::  ..:|..:|.||||:::.|.|....||             .|
Zfish   295 YRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSL-------------DQ 346

  Fly   533 AAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPV--- 594
            ||.|:        |..       |.|:|       :.|:.......:..:..|||...:.|.
Zfish   347 AASTK--------PSF-------TYNSP-------SNPVTENRRVGKSRVSRTKTKTRLSPYSQY 389

  Fly   595 ----TATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSG----SSSGLRPEEK 651
                |..|.:||      .:|:             ..||...:.:.|||..    .||.:..:..
Zfish   390 PGFPTDRSESDQ------DSPW-------------GGSPLTDSASPQLLEQCEGIESSCVYRQFS 435

  Fly   652 RPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQ 716
            .|:|                     ||...||..:.:             :||:        ...
Zfish   436 DPRS---------------------LCYGLPLTEDHH-------------TSNE--------LYS 458

  Fly   717 NPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFS-DMLVGLMGTCL 780
            :|.  ::...:|.|..    || ..:...:|...:...|:.:.:.|.:.:|.: |...|:|
Zfish   459 HPH--SESCERGCCKA----GR-YFLGTPQPGREAWWGAARSVLPLPKSSPENGDSFEGVM---- 512

  Fly   781 LPE--DINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPL--SPLTPNSTATASN 841
             |.  .|:||.       ..| |:...|:.|:....:.|.|.:.:.....  ||..|:...|...
Zfish   513 -PHIASIHSLQ-------VRG-HWDEDSAVSSPDGGSASDSGDRFRADQCRSSPQEPSKIETLIR 568

  Fly   842 PSHQQQQQHHNQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSCSQHLHSPS-ITSKS 905
            .: ||..:....:.|.::.....|....||.:.|     |:..:.......|.....|: :.|.:
Zfish   569 AT-QQMIKEEESRLQLRKLPTDVPLEPTNSLAKS-----FHSTDFPQSAMQSVVCRGPAQVISPA 627

  Fly   906 PEDSSLPSLCS--PNSLTQEDDF 926
            |....|..|.|  |:.|::..||
Zfish   628 PSPVPLSRLSSPLPDRLSKGKDF 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	25/48 (52%)
		PAS	256..392	CDD:279347	43/148 (29%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	39/102 (38%)
		PAS_3	417..502	CDD:285623	31/86 (36%)
sim1a	NP_835740.2	HLH	2..52	CDD:238036	26/49 (53%)
		PAS	79..>141	CDD:279347	23/61 (38%)
		PAS	88..>158	CDD:238075	22/78 (28%)
		PAS	229..328	CDD:238075	36/98 (37%)
		PAS_3	243..329	CDD:285623	31/85 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..413		17/103 (17%)
		SIM_C	359..647	CDD:284122	69/381 (18%)
		Nuclear localization signal. /evidence=ECO:0000250	368..387		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910