DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and Ahr

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	NP_037281.3	Gene:	Ahr / 25690	RGDID:	2074	Length:	853	Species:	Rattus norvegicus

Alignment Length:	979	Identity:	199/979 - (20%)
Similarity:	344/979 - (35%)	Gaps:	272/979 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 KSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCNDD 226
            ||..:.|.|....||: ..|::.||...|.:::|||.||:|:::::|:.:..  |..:|:
  Rat    31 KSNPSKRHRDRLNTEL-DRLASLLPFPQDVISKLDKLSVLRLSVSYLRAKSF--FDVALK----- 87

  Fly   227 IKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYLGI 291
                 .|..|:...:.:......||.:..|. |.|.|.::||:||::.:..:.|.|..:.:|||.
  Rat    88 -----STPADRSRGQDQCRAQVRDWQDLQEG-EFLLQALNGFVLVVTADALVFYASSTIQDYLGF 146

  Fly   292 TKIDTLGQQIWEYSHQCDHAEIKEAL------SLKRELAQKVKDE----------------PQQN 334
            .:.|.:.|.::|..|..|.||.:..|      |...:.||.| ||                |.:|
  Rat   147 QQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTDSAQGV-DETHGLPQPAVYYTPDQLPPEN 210

  Fly   335 SGVSTHHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVV----NAKG--------ERLLMA 387
            :...  .|....||:|.|.:        |:.:..::..|.|..    |.||        :..|.|
  Rat   211 TAFM--ERCFRCRLRCLLDN--------SSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFA 265

  Fly   388 IGRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDT-SLFSCQHGADSER 451
            |..|:..||.:||......|.|||.||......|.|...:|||:..:|.:. |.:...|.||...
  Rat   266 IATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCNKGSGYQFIHAADMLH 330

  Fly   452 LMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHEIYS 516
            ...:...::..|:...:.:|.|.|:..:.|:.|.|.::|...:|.                  |.
  Rat   331 CAESHIRMIKTGESGMTVFRLLAKHSRWRWVQSNARLIYRNGRPD------------------YI 377

  Fly   517 LAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKT 581
            :|.|...::::.:.|....:...|...|..:.:..|..... :||      ..||
  Rat   378 IATQRPLTDEEGREHLQKRSMTLPFMFATGKAVLYEISSPF-SPI------MDPL---------- 425

  Fly   582 IEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGL 646
                       |:...|...:....|:|.|.|
  Rat   426 -----------PIRTKSNTSRKDWAPQSTPSK--------------------------------- 446

  Fly   647 RPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLG---VEPNLPPTTTATAAIISSSNQQLQ 708
              :...|.|:.:::::...:..|.||.:     ..||.   :..::....:...:..::||:.|
  Rat   447 --DSFHPNSLMSALIQQDESIYLCPPSS-----PAPLDSHFLMDSMSECGSWQGSFAAASNEAL- 503

  Fly   709 IAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLV 773
             .:..::::.|.....:|.|...||             ||:.::.|.|               ::
  Rat   504 -LKHEEIRHTQDVNLTLSGGPSELF-------------PDNKNNDLYS---------------IM 539

  Fly   774 GLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPS-NTSSSNNSYANSPLSPLTPNSTA 837
            ..:|...  |||.|:.:.        :.:::.||....... :.:....:|....|:    |||.
  Rat   540 RNLGIDF--EDIRSMQNE--------EFFRTDSSGEVDFKDIDITDEILTYVQDSLN----NSTL 590

  Fly   838 TASNPSHQQQQQHHN-------QQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSCSQH 895
            ..|....|...||.:       |.:||||.||.||        :..::|    :.:.......||
  Rat   591 LNSACQQQPVSQHLSCMLQERLQLEQQQQLQQQHP--------TQTLEP----QRQLCQVEVPQH 643

  Fly   896 LHSPSITSKSPEDSSLPSLCSPN-------SLTQEDDFSFEAF------AMRAPYIPIDDDMP-- 945
                .:..|:..........|.|       |..|::...:..|      |...||....|.||
  Rat   644 ----ELGQKTKHMQVNGMFASWNPAPPVSFSCPQQERKHYSLFSGLQGTAQEFPYKSEVDSMPYT 704

  Fly   946 ---------LLTE----TDLMWCPPEDLQTMVPKEIDAIQQQLQQLQQQHHQQ------------ 985
                     ||.|    |.|.: |..|.:..:......::..:..||...:|:
  Rat   705 QNFAPCNQSLLPEHSKGTQLDF-PGRDFERSLHPNASNLEDFVSCLQVPENQRHGINSQSAMVSP 768

  Fly   986 ---YAGNTGYQQQQQQPQ---LQQQHFSNSLCSSPASTVSSLSPSPVQQHHQQQQAAVFTSDSSE 1044
               |||.....|.|..||   :.|..:|..:..|.|......|||.:.:        .:::|.|.
  Rat   769 QAYYAGAMSMYQCQAGPQHTPVDQMQYSPEIPGSQAFLSKFQSPSILNE--------AYSADLSS 825

  Fly  1045 LAAL 1048
            :..|
  Rat   826 IGHL 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	16/46 (35%)
		PAS	256..392	CDD:279347	43/169 (25%)
		PAS	265..>317	CDD:238075	16/51 (31%)
		PAS	404..505	CDD:238075	25/101 (25%)
		PAS_3	417..502	CDD:285623	19/85 (22%)
Ahr	NP_037281.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		2/6 (33%)
		HLH	36..77	CDD:238036	14/41 (34%)
		DNA-binding. /evidence=ECO:0000250\|UniProtKB:P35869	37..65		9/28 (32%)
		PAS	111..>181	CDD:279347	22/70 (31%)
		PAS	111..177	CDD:214512	21/66 (32%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250\|UniProtKB:P30561	116..124		3/7 (43%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250\|UniProtKB:P30561	264..266		0/1 (0%)
		PAS	280..384	CDD:238075	28/121 (23%)
		PAS_3	295..380	CDD:285623	20/102 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..451		5/56 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4449
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960