Protein Alignment sima and Arnt

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_036912.3
• Gene: Arnt / 25242
• RGDID: 2153
• Length: 809
• Species: Rattus norvegicus
• Alignment Length: 982
• Identity: 201/982 - (20%)
• Similarity: 345/982 - (35%)
• Gaps: 341/982 - (34%)

  Fly    41 QLSRNGPAFGPMPINEPTVNFGNGSFYNGPAPGSQPFVGAMLGPNMSSTGMQRYHPYHQQQPQDA 105
            :::.:.|:.|      ||:..||      |.||.|. .||::                    |.|
  Rat     9 EMTSDVPSLG------PTIASGN------PGPGIQG-GGAVV--------------------QRA 40

  Fly   106 FYRQRGSLLNVATPCRESRPWSYAYCYGYAPTNTQPC----QFSQFVDIEDFMNNEK-RKEKSRD 165
            ..|:.|...:.......    .:..|     .:.|.|    :|::..|.:...:.|: .:|...:
  Rat    41 IKRRSGLDFDDEGEVNS----KFLRC-----DDEQMCNDKERFARSDDEQSSADKERLARENHSE 96

  Fly   166 AARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCNDDIKQD 230
            ..|.||:|.|....|||..:|..:....:.||.:::|:.::.:|         |||...:
  Rat    97 IERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------SLRGTGN----- 147

  Fly   231 IETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHE-GDITYVSENVVEYLGITKI 294
              |:.| ...||       .:|...|.:.|:.:..||||.::|.| |.:.|||::|...|...:.
  Rat   148 --TSTD-GSYKP-------SFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQS 202

  Fly   295 DTLGQQIWEYSHQCDHAEIKEALSLK------RELAQK---VKDEPQQNS-----GVSTHHRDLF 345
            :..|..:::..|..|..:::|.||..      |.|..|   ||.|.||:|     |   ..|...
  Rat   203 EWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG---SRRSFI 264

  Fly   346 VRLKCTLTS------------RGRSIN----IKSAS--YKVIHITGHLVV--------------N 378
            .|::|..:|            |.|..|    :|...  :.|:|.||::..              .
  Rat   265 CRMRCGTSSVDPVSMNRLSFLRNRCRNGLGSVKEGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEA 329

  Fly   379 AKGERL-LMAIGR----PIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDT 438
            .:|.:. |:||||    ..|:.:::......:.|:::|:::..||:||.:....:||.|::||..
  Rat   330 GQGSKFCLVAIGRLQVTSSPNCTDMSNICQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGK 394

  Fly   439 SLFSCQHGADSERLMATFKSVLS-KGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQS----- 497
            ::....|..|.:.|..:|:.|:. |||..:..:||..|...:.|:   .|..:....|.|
  Rat   395 NIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRAKNREWLWM---RTSSFTFQNPYSDEIEY 456

  Fly   498 VVCVNYVISNLENKHE--------------------------IYSLAQQTAASEQKEQHHQAAET 536
            ::|.|   :|::|..:                          ...||.:....:|::|..|..:.
  Rat   457 IICTN---TNVKNSSQEPRPTLSNTIQRSQLGPTTNLSLEMGTGQLASRQQQQQQQQQQQQQQQQ 518

  Fly   537 EKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAEKTIEETKTI------ATIPPVT 595
            :::.::....|:.....::.:.:..| |::..:|:.....:..|.:|:::.:      .....:.
  Rat   519 QQQQQQQQQTELDMVPGRDGLASYSH-SQVSVQPVATAGSEHSKPLEKSEGLFVQDRDPRFSEIY 582

  Fly   596 ATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTI--TAQLLSGSSSGLRPEEKRPKSVTA 658
            ...:|||.|.|..|                       |:  |.||.|..||
  Rat   583 PNISADQSKGLSSS-----------------------TVPATQQLFSQGSS-------------- 610

  Fly   659 SVLRPSPAPP-------LTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQL-QIAQQTQL 715
              ..|:|.|.       ||||.|.         |:|:            ||:.|.| ||::.:.|
  Rat   611 --FPPNPRPAENFRNSGLTPPVTI---------VQPS------------SSAGQILAQISRHSNL 652

  Fly   716 QNPQQPAQDMS--KGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLMGT 778
            .....|....|  .||.:
  Rat   653 TQGSAPTWTSSTRPGFSA----------------------------------------------- 670

  Fly   779 CLLPEDINSLDSTTCSTTASGQ----HYQSPSS-SSTSAPSNTSSSNNSYANSPLSPLTPN---- 834
                    .|.:...:.|.|.|    ::|:.|| |:.|.|...::|.::.|    .|..||
  Rat   671 --------QLPTQATAKTRSSQFGVNNFQTSSSFSAMSLPGAPTASPSTAA----YPTLPNRGSN 723

  Fly   835 ------------STATASN----PSHQQQQQHH----NQQQQQQQQQQHHPQHH----------D 869
                        .|.||..    |..|.||.||    |:|..|....|...|..          |
  Rat   724 FPPETGQTTGQFQTRTAEGVGVWPQWQGQQPHHRSSSNEQHVQPTSAQPSSQPEVFQEMLSMLGD 788

  Fly   870 NSNSSSN 876
            .||:.:|
  Rat   789 QSNTYNN 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	14/56 (25%)
		PAS	256..392	CDD:395786	48/187 (26%)
		PAS	265..>317	CDD:238075	16/52 (31%)
		PAS	404..505	CDD:238075	28/106 (26%)
Arnt	NP_036912.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		10/36 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..95		4/21 (19%)
		bHLH-PAS_ARNT	86..150	CDD:381517	19/79 (24%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P53762	88..128		10/39 (26%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250|UniProtKB:P53762	112..264		46/178 (26%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250|UniProtKB:P53762	112..168		16/79 (20%)
		PAS	163..269	CDD:395786	32/108 (30%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250|UniProtKB:P53762	167..171		1/3 (33%)
		PAS_11	362..462	CDD:464214	28/105 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	465..487		1/21 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..575		4/29 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..685		7/86 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	699..735		7/39 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	748..809		14/48 (29%)