DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and Sim2

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	XP_006523029.1	Gene:	Sim2 / 20465	MGIID:	98307	Length:	661	Species:	Mus musculus

Alignment Length:	578	Identity:	162/578 - (28%)
Similarity:	266/578 - (46%)	Gaps:	86/578 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVP--SLRD 222
            ||||::||:.||.||...|.||:..|||.:...:||||||::|:|.::||:|.:.   |  ....
Mouse     2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVF---PEGEAAG 63

  Fly   223 CNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVE 287
            ..|...|...|.......|   |:|:.           |.||:|||:.|::.:|.|.|:||....
Mouse    64 LGDAWGQPSRTGPLDSVAK---ELGSH-----------LLQTLDGFVFVVASDGKIMYISETASV 114

  Fly   288 YLGITKIDTLGQQIWEYSHQCDHAEIKEALS----LKRELAQKVKDEPQQNSGVSTHHRDLFVRL 348
            :||:::::..|..|:||.|..||.|:...|:    |...|.|:.:.|           |..|:|:
Mouse   115 HLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPPLHHHLLQEYEIE-----------RSFFLRM 168

  Fly   349 KCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERL-----------LMAIGRPIPHPSNIEIPL 402
            ||.|..  |:..:..:.|||||.:|:|.:......:           |:|:|:.:|..:..||.|
Mouse   169 KCVLAK--RNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKL 231

  Fly   403 GTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQGET 467
            .::.|:.:.|||::..::|.::.:|.||.|:||::.:|:...||.|:..|......:|.|||..|
Mouse   232 HSNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVTT 296

  Fly   468 SRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQKEQH 530
            ..||.|.|.||:.|:.|.||:|::  ..:|..:|.||||::::|.| |:.....|.:.|:.:|..
Mouse   297 KYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTDVEYK-ELQLSLDQVSTSKSQESW 360

  Fly   531 HQAAETEKEPEKAADPEIIAQETKETVN--TPIHTSELQAKPLQLESEKAEKTIEETKTIATIPP 593
            .....|.:|..|:|.|:....:||...|  .|...|..|...|:.......:|...|..:|....
Mouse   361 RTTLSTSQETRKSAKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECSQVGNWRTSPPTNAVAPPEQ 425

  Fly   594 VTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTA 658
            ...:..:|.:...|.|.|:..         ...|.|    :.:.:.|....||..:..:|:....
Mouse   426 QLHSEASDLLYGPPYSLPFSY---------HYGHFP----LDSHVFSSKKPGLPAKFGQPQGSPC 477

  Fly   659 SVLR------PSPAP----------PLTPPPTAVLCKKTPL-----GVEPNLPPTTTA 695
            .|.|      |:.:.          |.:..|...|.:.:|:     |:.||....:.|
Mouse   478 EVARFFLSTLPASSECQWHCANSLVPSSSSPAKNLSEPSPVNAARHGLVPNYEAPSAA 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	24/48 (50%)
		PAS	256..392	CDD:279347	44/150 (29%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	37/102 (36%)
		PAS_3	417..502	CDD:285623	30/86 (35%)
Sim2	XP_006523029.1	bHLH_SF	1..78	CDD:381792	31/78 (40%)
		PAS	83..144	CDD:214512	24/71 (34%)
		PAS_3	247..333	CDD:369881	30/85 (35%)
		SIM_C	363..654	CDD:369005	36/186 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847529
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840