Protein Alignment sima and Sim1

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: XP_006512689.1
• Gene: Sim1 / 20464
• MGIID: 98306
• Length: 801
• Species: Mus musculus
• Alignment Length: 798
• Identity: 205/798 - (25%)
• Similarity: 344/798 - (43%)
• Gaps: 161/798 - (20%)

  Fly   160 KEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDC- 223
            ||||::|||.||.||...|.||:..|||.:...:||||||::|:|.::||:|.:.   |.:| |
Mouse     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVF---PEVR-CK 62

  Fly   224 --------------NDDIKQDIETAEDQQEVKPKLEVGTEDWLN----------GAEARELLKQT 264
                          ...|.:..||..:..:.   |.:| |.|.:          |.|....|.||
Mouse    63 FRMQTPGFLRYSLMGPGISRRKETDSNNSDY---LGLG-EAWGHTSRTSPLDNVGRELGSHLLQT 123

  Fly   265 MDGFLLVLSHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKD 329
            :|||:.|::.:|.|.|:||....:||:::::..|..|:||.|..||.|:...|:         ..
Mouse   124 LDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT---------AH 179

  Fly   330 EPQQNSGVSTH--HRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERL-------- 384
            :|..:..|..:  .|..|:|:||.|..  |:..:....|||||.:|:|.:......:
Mouse   180 QPYHSHFVQEYEIERSFFLRMKCVLAK--RNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQ 242

  Fly   385 ---LMAIGRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHG 446
               |:|:|..:|..:..||.|.::.|:.:.||||:..::|.::.:|.||.|:||::.:|:...||
Mouse   243 NVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHG 307

  Fly   447 ADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLE 509
            .|:..|......:|.|||..|..||||.|.||:.|:.|.||||::  ..:|..:|.||||:::.|
Mouse   308 CDTFHLRCAHHLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTE 372

  Fly   510 NKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVN-----TPIHTSELQAK 569
            .|....||.|.:|:.........:..|..:..|.|...:.:.::|...:     :..||...::
Mouse   373 YKGLQLSLDQISASKPTFSYTSSSTPTISDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSES- 436

  Fly   570 PLQLESEKAEKTIEETKTIATIPPVTATSTAD---QIKQLPESNP--YKQILQAELLIK-RENHS 628
              ..:|:.....:.:|.:...:.|....|..:   ..:|.|:.:.  |...|....|:: |..|:
Mouse   437 --DHDSQWGGSPLTDTASPQLLDPERPGSQHELSCAYRQFPDRSSLCYGFALDHSRLVEDRHFHT 499

  Fly   629 ---PGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTP---LGVEP 687
               .|.|....:...|:.    |..:.|...:.:.|      |||        |.:|   ...|.
Mouse   500 QACEGGRCEAGRYFLGAP----PTGRDPWWGSRAAL------PLT--------KASPESREAYEN 546

  Fly   688 NLPPTTTA----------TAAIIS-----SSNQQLQIAQQTQLQN-PQQPA--QDMSKGFCSLFA 734
            ::|..|:.          ..:::|     |:::.....:..|.|| |.:|:  :.:.:....:..
Mouse   547 SMPHITSIHRIHGRGHWDEDSVVSSPDPGSASESGDRYRTEQYQNSPHEPSKIETLIRATQQMIK 611

  Fly   735 DDGRGLTMLKEEPDDLS--------HHLASTNCIQ------------LDEMTPFSDMLVGLMGTC 779
            ::...|.:.|..||.|:        |.|...|..|            |...:| .|.:....|..
Mouse   612 EEENRLQLRKAPPDQLASINGAGKKHSLCFANYQQPPPTGEVCHSSALASTSP-CDHIQQREGKM 675

  Fly   780 LLPEDINSLDSTTCSTTASGQHYQSPSS-SSTSAPSNTSSSNNS------YANSPLSPLTPNSTA 837
            |.|.: |..|:             ||:: |..|:||:...:.:|      |.:|.:||.......
Mouse   676 LSPHE-NDYDN-------------SPTALSRISSPSSDRITKSSLILAKDYLHSDMSPHQTAGDH 726

  Fly   838 TASNP----SHQQQQQHH 851
            .|.:|    ||:|....|
Mouse   727 PAISPNCFGSHRQYFDKH 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	28/55 (51%)
		PAS	256..392	CDD:395786	43/148 (29%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	40/102 (39%)
Sim1	XP_006512689.1	bHLH-PAS_SIM1	1..107	CDD:381581	38/112 (34%)
		PAS	124..>194	CDD:238075	22/78 (28%)
		PAS_3	279..365	CDD:430001	32/85 (38%)
		SIM_C	395..704	CDD:461963	61/344 (18%)