DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and EPAS1

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	XP_011531000.1	Gene:	EPAS1 / 2034	HGNCID:	3374	Length:	883	Species:	Homo sapiens

Alignment Length:	772	Identity:	223/772 - (28%)
Similarity:	362/772 - (46%)	Gaps:	210/772 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 NNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPS 219
            ::|:||||||||||||||||||:|.||:..|||.....:.|||||:||:.|:||:..::|..|
Human    24 SSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSV-- 86

  Fly   220 LRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSEN 284
               |:::   :.|...|||                  ...|..:.::||:.|::.:||:.::|||
Human    87 ---CSEN---ESEAEADQQ------------------MDNLYLKALEGFIAVVTQDGDMIFLSEN 127

  Fly   285 VVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKR--ELAQKVKDEPQQNSGVSTHHRDLFVR 347
            :.:::|:|:::..|..|::::|.|||.||:|.||||.  ...:|.||       :|| .||.|:|
Human   128 ISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKD-------MST-ERDFFMR 184

  Fly   348 LKCTLTSRGRSINIKSASYKVIHITGHLVV--------NAKGER-----LLMAIGRPIPHPSNIE 399
            :|||:|:|||::|:|||::||:|.||.:.|        :..|.:     .|:.:..||.|||:::
Human   185 MKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMD 249

  Fly   400 IPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLSKGQ 464
            |||.:.|||::||:||:|||.||::.:|:||.|::||..|.:...|..|||.:..:.:::.:|||
Human   250 IPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQ 314

  Fly   465 GETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAASEQK 527
            ..:.:||.|.|:|||.|:.:|.|::|:  .|:||.::|||||:|.:|....::|:.|
Human   315 VVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQ-------- 371

  Fly   528 EQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKAE----KTIEETKTI 588
                  .|:..:|...|...|.....|..|                 |||:.    |..||.:.:
Human   372 ------TESLFKPHLMAMNSIFDSSGKGAV-----------------SEKSNFLFTKLKEEPEEL 413

  Fly   589 ATIPPVTATSTADQI-------KQLPESNPY-KQILQAELLIKRENHSPGPRTITAQLLSGSSSG 645
            |.:.|    :..|.|       :...||:.| |.||            |..:....:|.|.|:
Human   414 AQLAP----TPGDAIISLDFGNQNFEESSAYGKAIL------------PPSQPWATELRSHST-- 460

  Fly   646 LRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIA 710
                    :|...|:      |..|.|..|.             |.:||.:|...|||
Human   461 --------QSEAGSL------PAFTVPQAAA-------------PGSTTPSATSSSSS------- 491

  Fly   711 QQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGL 775
                               ||           ....|:|  ::.:..|.::::.:.....|....
Human   492 -------------------CS-----------TPNSPED--YYTSLDNDLKIEVIEKLFAMDTEA 524

  Fly   776 MGTCLLPEDINSLDSTTCS--TTASGQHYQ-SP--------SSSSTSAPSNT-SSSNNSYANSPL 828
            ...|....|.|.||..|.:  ....|:.:| ||        :.:..|.|.:. |:..|.:  .||
Human   525 KDQCSTQTDFNELDLETLAPYIPMDGEDFQLSPICPEERLLAENPQSTPQHCFSAMTNIF--QPL 587

  Fly   829 SPLTPNSTATASNPSHQQQQQHHNQQQQQQQQQQHHPQHHDNSN------SSSNIDP 879
            :|:.|:|....            ::.|||.:.::..|:|...|:      |.:::.|
Human   588 APVAPHSPFLL------------DKFQQQLESKKTEPEHRPMSSIFFDAGSKASLPP 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	34/52 (65%)
		PAS	256..392	CDD:279347	52/150 (35%)
		PAS	265..>317	CDD:238075	19/51 (37%)
		PAS	404..505	CDD:238075	44/102 (43%)
		PAS_3	417..502	CDD:285623	34/86 (40%)
EPAS1	XP_011531000.1	HLH	25..81	CDD:238036	35/55 (64%)
		PAS	99..160	CDD:214512	21/78 (27%)
		PAS	254..353	CDD:238075	40/98 (41%)
		PAS_3	267..354	CDD:285623	34/86 (40%)
		HIF-1	530..562	CDD:288296	9/31 (29%)
		HIF-1a_CTAD	846..882	CDD:285931
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157116
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm42186
orthoMCL	1	0.900	-	-		OOG6_106128
Panther	1	1.100	-	-	O	PTHR23043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1038
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.840