Protein Alignment sima and AHR

DIOPT Version :9

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001612.1
• Gene: AHR / 196
• HGNCID: 348
• Length: 848
• Species: Homo sapiens
• Alignment Length: 982
• Identity: 209/982 - (21%)
• Similarity: 348/982 - (35%)
• Gaps: 288/982 - (29%)

  Fly   162 KSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREM----LQFVPSLRD 222
            ||..:.|.|....||: ..|::.||...|.:|:|||.||:|:::::|:.:..    |:..|:.|:
Human    32 KSNPSKRHRDRLNTEL-DRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERN 95

  Fly   223 CNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVE 287
            ...|   :...|..::.:  .|:.|           |.|.|.::||:||::.:..:.|.|..:.:
Human    96 GGQD---NCRAANFREGL--NLQEG-----------EFLLQALNGFVLVVTTDALVFYASSTIQD 144

  Fly   288 YLGITKIDTLGQQIWEYSHQCDHAE--------------------IKEALSLKRELAQKVKDE-P 331
            |||..:.|.:.|.::|..|..|.||                    |:||..|.:.:.....|: |
Human   145 YLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIP 209

  Fly   332 QQNSGVSTHHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVV----NAKG--------ERL 384
            .:||.:.  .|....||:|.|.:        |:.:..::..|.|..    ..||        :..
Human   210 PENSPLM--ERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLA 264

  Fly   385 LMAIGRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDT-SLFSCQHGAD 448
            |.||..|:..||.:||......|.|||.||......|.|...:|||:..:|... |.:...|.||
Human   265 LFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAAD 329

  Fly   449 SERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHE 513
            ......:...::..|:.....:|.|.|...:.|:.|.|.::|...:|      :|:|
Human   330 MLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKNGRP------DYII-------- 380

  Fly   514 IYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKA 578
               :.|:....|:..:|.:...| |.|......|.:..|.
Human   381 ---VTQRPLTDEEGTEHLRKRNT-KLPFMFTTGEAVLYEA------------------------- 416

  Fly   579 EKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSS 643
                                          :||:..|:. .|.::.:|.:.|..:.|...||..|
Human   417 ------------------------------TNPFPAIMD-PLPLRTKNGTSGKDSATTSTLSKDS 450

  Fly   644 SGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISS-SNQQL 707
                   ..|.|:.|::::...:..|.|                  ..:|::||...:: .|:.:
Human   451 -------LNPSSLLAAMMQQDESIYLYP------------------ASSTSSTAPFENNFFNESM 490

  Fly   708 Q----------------IAQQTQLQNPQQPAQDMSKGFCSLFADDGRG--LTMLKEEPDDLS--H 752
            .                |.:..|:..||. ....:.|...||.|....  .:::|....|..  .
Human   491 NECRNWQDNTAPMGNDTILKHEQIDQPQD-VNSFAGGHPGLFQDSKNSDLYSIMKNLGIDFEDIR 554

  Fly   753 HLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTS 817
            |:.:....:.|    ||..:           |...:|.|....|    :.|...|.|...||:..
Human   555 HMQNEKFFRND----FSGEV-----------DFRDIDLTDEILT----YVQDSLSKSPFIPSDYQ 600

  Fly   818 SSNNSYANSPLSPLTPNSTATASNPSH-QQQQQHHNQQ-----QQQQQQQQHHPQHH---DNSNS 873
            ...:         |..||:.......| :||||||.:|     |||..|:..|.|.:   :|.||
Human   601 QQQS---------LALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNS 656

  Fly   874 SSNIDPLFNY-REESNDTSCSQHLHSPSITSKSPEDSSLPSL--------CSPNSLTQ-----ED 924
            :..:.  ||. :::....:....||  .|:.:.|..|.:.|:        |:...|.|     |.
Human   657 NQFVP--FNCPQQDPQQYNVFTDLH--GISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTEL 717

  Fly   925 DF---SFEAFAMRAPYIPIDDDMPLLTETDLMWC--PPEDLQ--------TMVPKEIDAIQQQLQ 976
            |:   |||.    :|| |....:     .|.:.|  .||:.:        .:.|:...|....:.
Human   718 DYPMGSFEP----SPY-PTTSSL-----EDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMY 772

  Fly   977 QLQQQHHQQYAGNTGYQQQQQQPQLQQQH-----FSNSLCSS--PA--------STVSSLSPSPV 1026
            |.|.:....:.|     |.|..|.|..|.     |.|.:.:.  ||        .|.:.|.|
Human   773 QCQPEPQHTHVG-----QMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQP--- 829

  Fly  1027 QQHHQQQ 1033
             .||..:
Human   830 -LHHPSE 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	17/46 (37%)
		PAS	256..392	CDD:279347	40/168 (24%)
		PAS	265..>317	CDD:238075	18/71 (25%)
		PAS	404..505	CDD:238075	26/101 (26%)
		PAS_3	417..502	CDD:285623	19/85 (22%)
AHR	NP_001612.1	HLH	37..78	CDD:238036	15/41 (37%)
		PAS	113..227	CDD:279347	31/126 (25%)
		PAS	122..224	CDD:238075	25/103 (24%)
		PAS_3	297..382	CDD:285623	21/101 (21%)
		PAS	298..386	CDD:238075	22/104 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4682
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960