DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sima and Npas1

DIOPT Version :9

Sequence 1:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster
Sequence 2:	NP_032744.1	Gene:	Npas1 / 18142	MGIID:	109205	Length:	594	Species:	Mus musculus

Alignment Length:	660	Identity:	179/660 - (27%)
Similarity:	271/660 - (41%)	Gaps:	167/660 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 VATP-----------CRESR----PWSYAYCYGY---APTNTQPCQFSQFVDIEDFMNNEKRKEK 162
            :|||           |...|    ||.  :..|.   ||..  ||..:|            ||||
Mouse     1 MATPYPRSGGRGEVKCGGGRGAGVPWD--FLPGLMVKAPPG--PCLQAQ------------RKEK 49

  Fly   163 SRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREM--LQFVP-SLRDCN 224
            ||:|||.||.||...|.||:..|||.....:||||||::|:::.:|::|..  |...| .||
Mouse    50 SRNAARWRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLR--- 111

  Fly   225 DDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYL 289
             .:......|..::.....:....|..|.|.     :.|::|||:..|:.||...|:||.|..||
Mouse   112 -AVGPPAGLAPGRRGPVALVSEVFEQHLGGH-----ILQSLDGFVFALNQEGKFLYISETVSIYL 170

  Fly   290 GITKIDTLGQQIWEYSHQCDHAEIKEALSLK----------------RELAQKVKDEP------- 331
            |:::::..|..:::|.|..||:|:.|.|.|:                ...:..:.|.|
Mouse   171 GLSQVELTGSSVFDYIHPGDHSEVLEQLGLRAASIGPPTPPSVSSSSSSSSSSLVDTPEIEASPT 235

  Fly   332 QQNSGVSTHHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERLLMAIGRPIPHPS 396
            :.:.......|..|||:|.|||.||  :|:|::.|||||:||.|...|.|   |:|:|..:|...
Mouse   236 EASPAFRAQERSFFVRMKSTLTKRG--LNVKASGYKVIHVTGRLRARALG---LVALGHTLPPAP 295

  Fly   397 NIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLS 461
            ..|:||.....:.:.||.:.....:.::.|.:...|.:|:..|.:...||.|:.|:..:...:|.
Mouse   296 LAELPLHGHMIVFRLSLGLTILACESRVSDHMDMGPSELVGRSCYQFVHGQDATRIRQSHLDLLD 360

  Fly   462 KGQGETSRYRFLGKYGGYCWILSQATIVYD--KLKPQSVVCVNYVISNLENKHEIYSLAQQTAAS 524
            |||..|..||:|.:.||:.|:.|.||:..:  ......|:.|::|:||.|.........|..|..
Mouse   361 KGQVVTGYYRWLQRAGGFVWLQSVATVAGNGKSTGEHHVLWVSHVLSNAEGSQTPLDAFQLPAIV 425

  Fly   525 EQKEQHHQAAE-TEKEP------------EKAADPEIIAQETKETVNTPIHTSELQAKPLQLESE 576
            .|:|......| ||:||            :|..||:...:..|           ::|.|  .|:.
Mouse   426 SQEEPSRPGPEPTEEEPPVDGKQAVPADQDKDKDPQARGKRIK-----------VEASP--KEAR 477

  Fly   577 KAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPG-PRTITAQLLS 640
            .:|.:.||..:....||            .||   :..:::|..|    .|.|. |..:|.
Mouse   478 GSEDSGEEELSDPPAPP------------RPE---FTSVIRAGAL----KHDPVLPWGLTT---- 519

  Fly   641 GSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTP-------------------LGVE 686
                   |.:..|..:.|..|         ||....||  ||                   ||..
Mouse   520 -------PGDPSPALLHAGFL---------PPVVRGLC--TPGTIRYGPAELSLMYPHLHRLGAG 566

  Fly   687 PNLP----PT 692
            |:||    ||
Mouse   567 PSLPEAFYPT 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	HLH	156..209	CDD:238036	26/52 (50%)
		PAS	256..392	CDD:279347	50/158 (32%)
		PAS	265..>317	CDD:238075	20/51 (39%)
		PAS	404..505	CDD:238075	26/102 (25%)
		PAS_3	417..502	CDD:285623	23/86 (27%)
Npas1	NP_032744.1	bHLH-PAS_NPAS1_PASD5	43..116	CDD:381574	33/88 (38%)
		PAS	141..198	CDD:214512	21/61 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..237		2/30 (7%)
		PAS_3	316..387	CDD:369881	21/70 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..498		21/98 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910