DRSC/TRiP Functional Genomics Resources

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Protein Alignment sima and hif-1

DIOPT Version :9

Sequence 1:NP_001287599.1 Gene:sima / 43580 FlyBaseID:FBgn0266411 Length:1593 Species:Drosophila melanogaster
Sequence 2:NP_001023891.2 Gene:hif-1 / 180359 WormBaseID:WBGene00001851 Length:721 Species:Caenorhabditis elegans


Alignment Length:953 Identity:210/953 - (22%)
Similarity:336/953 - (35%) Gaps:322/953 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 NNEKRKEKSRDAARCRRSKETEIFMELSAALPL-KTDDVNQLDKASVMRITIAFLKIREMLQFVP 218
            |.|:|:|.||.|||.|||||::||.:|...:|: :...|..||:.:::|:.....::|       
 Worm     8 NMERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLR------- 65

  Fly   219 SLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSE 283
                         :||.:..|.....|:..|.|     ..:.:.:.:|||::::..:..|.||:|
 Worm    66 -------------KTAGNVLENNLDNEITNEVW-----TEDTIAECLDGFVMIVDSDSSILYVTE 112

  Fly   284 NVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRL 348
            :|..|||:|:.|..|:.:.::.|..|:.|..:    :.::..|.:.|....:|:     ::.:|:
 Worm   113 SVAMYLGLTQTDLTGRALRDFLHPSDYDEFDK----QSKMLHKPRGEDTDTTGI-----NMVLRM 168

  Fly   349 KCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERLLMAIGRPIPHPSNIEIPLGTST------- 406
            |..::.|||.:|:|||.||.:....|..|:..|....|         ..|.||.|..|       
 Worm   169 KTVISPRGRCLNLKSALYKSVSFLVHSKVSTGGHVSFM---------QGITIPAGQGTTNANASA 224

  Fly   407 -----------FLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVL 460
                       |.|:|:.|||.|:|.||.:.:|....|.|:.||.:...|.||...:..:.|.:.
 Worm   225 MTKYTESPMGAFTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVSKSMKELF 289

  Fly   461 SKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQS---VVCVNYVISNLENKHEIYSLAQQTA 522
            :||...|..||.:.......||.::||.:....|.|.   |:||:||:.....:..:........
 Worm   290 AKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVLGIQGAEESLVVCTDSMP 354

  Fly   523 ASEQKEQHHQAAETEKEPEKAAD-----PEIIAQETKETVN-TPIHTSELQAKPLQLESEKAEKT 581
            |..|       .:.:||.:...|     |||:     |.|: ||:           :|.|....|
 Worm   355 AGMQ-------VDIKKEVDDTRDYIGRQPEIV-----ECVDFTPL-----------IEPEDPFDT 396

  Fly   582 IEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGL 646
            :.|       |.|.......|.......|.|..:||   .:.|:                     
 Worm   397 VIE-------PVVGGEEPVKQADMGARKNSYDDVLQ---WLFRD--------------------- 430

  Fly   647 RPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQ 711
                                                   :|:.||                    
 Worm   431 ---------------------------------------QPSSPP-------------------- 436

  Fly   712 QTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLM 776
                     ||:..|       ||..|     ..||.:....|||                    
 Worm   437 ---------PARYRS-------ADRFR-----TTEPSNFGSALAS-------------------- 460

  Fly   777 GTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTP-------N 834
                 |:.::|...|:...|:.|:..||..|.:|.: |:||:|.....::..|||..       |
 Worm   461 -----PDFMDSSSRTSRPKTSYGRRAQSQGSRTTGS-SSTSASATLPHSANYSPLAEGISQCGLN 519

  Fly   835 STATASNPSHQ-------QQQQHHNQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSC 892
            |..:.|..|.|       ...:..:.....::.....|....|.:|:..|:|:..    |||...
 Worm   520 SPPSCSIKSGQVVYGDARSMGRSCDPSDSSRRFSALSPSDTLNVSSTRGINPVIG----SNDVFS 580

  Fly   893 SQHL-----------HSPSITSKSPEDSSLPSLCSPNSLTQEDDFSFEA--FAMRAPYIPIDDDM 944
            :...           .||::||..      |.||        ||..:|.  .:..||::...|.|
 Worm   581 TMPFADSIAIAERIDSSPTLTSGE------PILC--------DDLQWEEPDLSCLAPFVDTYDMM 631

  Fly   945 PLLTETDLMWCPPEDLQTM--VPKEIDAIQQ------------------------QLQQLQQQHH 983
            .:  :..|   ||| ||.:  :|....|:.|                        .|..:..||:
 Worm   632 QM--DEGL---PPE-LQALYDLPDFTPAVPQAPAARPVHIDRSPPAKRMHQSGPSDLDFMYTQHY 690

  Fly   984 QQYAGNTGYQQQQQQPQLQQQHFSNSLCSSPASTVSSLSPSPV 1026
            |.:..:..|.|.|||...||.              ||.||.|:
 Worm   691 QPFQQDETYWQGQQQQNEQQP--------------SSYSPFPM 719

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simaNP_001287599.1 HLH 156..209 CDD:238036 21/53 (40%)
PAS 256..392 CDD:279347 35/135 (26%)
PAS 265..>317 CDD:238075 17/51 (33%)
PAS 404..505 CDD:238075 35/121 (29%)
PAS_3 417..502 CDD:285623 26/87 (30%)
hif-1NP_001023891.2 HLH 10..66 CDD:238036 22/75 (29%)
PAS 94..>145 CDD:238075 17/54 (31%)
PAS 233..>312 CDD:238075 25/78 (32%)
PAS_11 236..338 CDD:291273 35/101 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 51 1.000 Domainoid score I7753
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000232
OrthoInspector 1 1.000 - - otm14250
orthoMCL 1 0.900 - - OOG6_106128
Panther 1 1.100 - - LDO PTHR23043
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4976
SonicParanoid 1 1.000 - - X1038
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.940

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