Protein Alignment sima and hif-1

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001023891.2
• Gene: hif-1 / 180359
• WormBaseID: WBGene00001851
• Length: 721
• Species: Caenorhabditis elegans
• Alignment Length: 953
• Identity: 210/953 - (22%)
• Similarity: 336/953 - (35%)
• Gaps: 322/953 - (33%)

  Fly   155 NNEKRKEKSRDAARCRRSKETEIFMELSAALPL-KTDDVNQLDKASVMRITIAFLKIREMLQFVP 218
            |.|:|:|.||.|||.|||||::||.:|...:|: :...|..||:.:::|:.....::|
 Worm     8 NMERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLR------- 65

  Fly   219 SLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSE 283
                         :||.:..|.....|:..|.|     ..:.:.:.:|||::::..:..|.||:|
 Worm    66 -------------KTAGNVLENNLDNEITNEVW-----TEDTIAECLDGFVMIVDSDSSILYVTE 112

  Fly   284 NVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRL 348
            :|..|||:|:.|..|:.:.::.|..|:.|..:    :.::..|.:.|....:|:     ::.:|:
 Worm   113 SVAMYLGLTQTDLTGRALRDFLHPSDYDEFDK----QSKMLHKPRGEDTDTTGI-----NMVLRM 168

  Fly   349 KCTLTSRGRSINIKSASYKVIHITGHLVVNAKGERLLMAIGRPIPHPSNIEIPLGTST------- 406
            |..::.|||.:|:|||.||.:....|..|:..|....|         ..|.||.|..|
 Worm   169 KTVISPRGRCLNLKSALYKSVSFLVHSKVSTGGHVSFM---------QGITIPAGQGTTNANASA 224

  Fly   407 -----------FLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVL 460
                       |.|:|:.|||.|:|.||.:.:|....|.|:.||.:...|.||...:..:.|.:.
 Worm   225 MTKYTESPMGAFTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVSKSMKELF 289

  Fly   461 SKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQS---VVCVNYVISNLENKHEIYSLAQQTA 522
            :||...|..||.:.......||.::||.:....|.|.   |:||:||:.....:..:........
 Worm   290 AKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVLGIQGAEESLVVCTDSMP 354

  Fly   523 ASEQKEQHHQAAETEKEPEKAAD-----PEIIAQETKETVN-TPIHTSELQAKPLQLESEKAEKT 581
            |..|       .:.:||.:...|     |||:     |.|: ||:           :|.|....|
 Worm   355 AGMQ-------VDIKKEVDDTRDYIGRQPEIV-----ECVDFTPL-----------IEPEDPFDT 396

  Fly   582 IEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSSSGL 646
            :.|       |.|.......|.......|.|..:||   .:.|:
 Worm   397 VIE-------PVVGGEEPVKQADMGARKNSYDDVLQ---WLFRD--------------------- 430

  Fly   647 RPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISSSNQQLQIAQ 711
                                                   :|:.||
 Worm   431 ---------------------------------------QPSSPP-------------------- 436

  Fly   712 QTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEEPDDLSHHLASTNCIQLDEMTPFSDMLVGLM 776
                     ||:..|       ||..|     ..||.:....|||
 Worm   437 ---------PARYRS-------ADRFR-----TTEPSNFGSALAS-------------------- 460

  Fly   777 GTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTSSSNNSYANSPLSPLTP-------N 834
                 |:.::|...|:...|:.|:..||..|.:|.: |:||:|.....::..|||..       |
 Worm   461 -----PDFMDSSSRTSRPKTSYGRRAQSQGSRTTGS-SSTSASATLPHSANYSPLAEGISQCGLN 519

  Fly   835 STATASNPSHQ-------QQQQHHNQQQQQQQQQQHHPQHHDNSNSSSNIDPLFNYREESNDTSC 892
            |..:.|..|.|       ...:..:.....::.....|....|.:|:..|:|:..    |||...
 Worm   520 SPPSCSIKSGQVVYGDARSMGRSCDPSDSSRRFSALSPSDTLNVSSTRGINPVIG----SNDVFS 580

  Fly   893 SQHL-----------HSPSITSKSPEDSSLPSLCSPNSLTQEDDFSFEA--FAMRAPYIPIDDDM 944
            :...           .||::||..      |.||        ||..:|.  .:..||::...|.|
 Worm   581 TMPFADSIAIAERIDSSPTLTSGE------PILC--------DDLQWEEPDLSCLAPFVDTYDMM 631

  Fly   945 PLLTETDLMWCPPEDLQTM--VPKEIDAIQQ------------------------QLQQLQQQHH 983
            .:  :..|   ||| ||.:  :|....|:.|                        .|..:..||:
 Worm   632 QM--DEGL---PPE-LQALYDLPDFTPAVPQAPAARPVHIDRSPPAKRMHQSGPSDLDFMYTQHY 690

  Fly   984 QQYAGNTGYQQQQQQPQLQQQHFSNSLCSSPASTVSSLSPSPV 1026
            |.:..:..|.|.|||...||.              ||.||.|:
 Worm   691 QPFQQDETYWQGQQQQNEQQP--------------SSYSPFPM 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	21/57 (37%)
		PAS	256..392	CDD:395786	35/135 (26%)
		PAS	265..>317	CDD:238075	17/51 (33%)
		PAS	404..505	CDD:238075	35/121 (29%)
hif-1	NP_001023891.2	bHLH_SF	12..66	CDD:469605	21/73 (29%)
		PAS	89..142	CDD:214512	16/52 (31%)
		PAS_11	236..338	CDD:464214	35/101 (35%)