Protein Alignment sima and aha-1

DIOPT Version :10

• Sequence 1: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Sequence 2: NP_001251327.1
• Gene: aha-1 / 172889
• WormBaseID: WBGene00000095
• Length: 453
• Species: Caenorhabditis elegans
• Alignment Length: 399
• Identity: 91/399 - (22%)
• Similarity: 160/399 - (40%)
• Gaps: 79/399 - (19%)

  Fly   125 PWSYAYCYGYAPTNT-QPCQFSQFVDIEDFMNNEKR---KEKSRDAARCRRSKETEIFMELSAAL 185
            ||..|..:.....:. .|.  .::..:||.|...|.   :|...:..|.||:|.|....||:..:
 Worm     9 PWQSATSFAMEDEDMGMPS--GKYARMEDEMGENKERFARENHSEIERRRRNKMTHYINELAEMV 71

  Fly   186 PLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTED 250
            |.......:.||.:::|:.::.:|         .:|.         .||:|:...||       .
 Worm    72 PQCASLGRKPDKLTILRMAVSHMK---------GIRG---------HTAQDETSYKP-------S 111

  Fly   251 WLNGAEARELLKQTMDGFLLVL-SHEGDITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIK 314
            :|...|.:.|:.:..:|||.|: ...|.:.||::::...|.:.:.|.|.:.:.|..|..|..:|:
 Worm   112 FLTDQELKHLILEAANGFLFVVCCQTGKVLYVADSITPVLNLKQEDWLQRNLNELIHPDDQDKIR 176

  Fly   315 EALSLKRELAQKV---KDEPQQNSGVSTH-----HRDLFVRLKC-------TLTSRGRSINIKSA 364
            :.|........||   |....:..|.||.     .|....|::.       .|.:|.........
 Worm   177 DQLCGSEVSVNKVLDLKSGSVKREGASTRVHMSCRRGFICRMRVGALEPLHRLRNRRPLFQHAGQ 241

  Fly   365 SYKVIHITGHLV------VNAKGERLLMAIGR------PIPHPSNIEIPLGTSTFLTKHSLDMRF 417
            :|.|:|.||::.      :||.....|:||.|      |:     ...|..|:.|..:.|.|.:.
 Worm   242 NYVVMHCTGYIKNAPPQGINAPASSCLVAIARLQVASMPV-----CADPTSTNQFSVRVSEDGKM 301

  Fly   418 TYVDDKMHDLLGYSPKDLLDTSLFSCQHGADSERLMATFKSVLS--------KGQGET------- 467
            |::|.::.||:|.|...|:....::..|.||.:.|..:|.::||        :.:..|
 Worm   302 TFIDARVSDLIGLSSDQLIGRYWWNLAHPADEKTLQDSFVALLSDQPMRINIRVRTSTDYIPCTV 366

  Fly   468 SRYRFLGKY 476
            |.|:|:..|
 Worm   367 SAYKFMNPY 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	13/59 (22%)
		PAS	256..392	CDD:395786	38/163 (23%)
		PAS	265..>317	CDD:238075	14/52 (27%)
		PAS	404..505	CDD:238075	23/88 (26%)
aha-1	NP_001251327.1	bHLH-PAS_ARNT	41..105	CDD:381517	17/81 (21%)
		PAS	120..179	CDD:214512	15/58 (26%)
		PAS_11	288..393	CDD:464214	23/88 (26%)